TISIDB

Summary
Symbol	SIGLEC1
Name	sialic acid binding Ig-like lectin 1, sialoadhesin
Aliases	SIGLEC-1; CD169; FLJ00051; FLJ00055; FLJ00073; FLJ32150; dJ1009E24.1; sialoadhesin; sialic acid-binding Ig-l ......
Chromosomal Location	20p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Secreted.
Domain	PF08205 CD80-like C2-set immunoglobulin domain PF07679 Immunoglobulin I-set domain PF13895 Immunoglobulin domain PF07686 Immunoglobulin V-set domain
Function	Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.

> Gene Ontology [ TOP ]
Biological Process	GO:0007160 cell-matrix adhesion GO:0031589 cell-substrate adhesion
Molecular Function	GO:0030246 carbohydrate binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04514 Cell adhesion molecules (CAMs)
Reactome	R-HSA-1280218: Adaptive Immune System R-HSA-168256: Immune System R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Summary
Symbol	SIGLEC1
Name	sialic acid binding Ig-like lectin 1, sialoadhesin
Aliases	SIGLEC-1; CD169; FLJ00051; FLJ00055; FLJ00073; FLJ32150; dJ1009E24.1; sialoadhesin; sialic acid-binding Ig-l ......
Chromosomal Location	20p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SIGLEC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between SIGLEC1 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
26714554	Melanoma	Promote immunity	The iPS-ML-IFNs increased the expression of CD169, a marker of M1 macrophages that can activate antitumor immunity.
26647968	Melanoma	Inhibit immunity (T cell function)	CD169(-/-) mice had significantly enhanced in vivo cytotoxic T lymphocyte responses to antigen-pulsed ApoVs, indicating a suppressive role for CD169(+) macrophages to ApoV-associated antigen.
21194983	Lymphoma	Promote immunity (T cell function)	Here we show that CD169(+) macrophages phagocytose dead tumor cells transported via lymphatic flow and subsequently crosspresent tumor antigens to CD8(+) T?cells. However, tumor antigen-specific CD8(+) T?cell activation and subsequent antitumor immunity are severely impaired in mice depleted with CD169(+) macrophages. Thus, we have identified CD169(+) macrophages as lymph node-resident APCs dominating early activation of tumor antigen-specific CD8(+) T?cells.

Summary
Symbol	SIGLEC1
Name	sialic acid binding Ig-like lectin 1, sialoadhesin
Aliases	SIGLEC-1; CD169; FLJ00051; FLJ00055; FLJ00073; FLJ32150; dJ1009E24.1; sialoadhesin; sialic acid-binding Ig-l ......
Chromosomal Location	20p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of SIGLEC1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SIGLEC1
Name	sialic acid binding Ig-like lectin 1, sialoadhesin
Aliases	SIGLEC-1; CD169; FLJ00051; FLJ00055; FLJ00073; FLJ32150; dJ1009E24.1; sialoadhesin; sialic acid-binding Ig-l ......
Chromosomal Location	20p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of SIGLEC1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.509	0.231
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.395	0.724
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.598	0.519
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.344	0.506
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.112	0.959
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.921	0.742
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.192	0.719
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.516	0.706
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.298	0.858
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	1.946	0.0976
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.793	0.321
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.08	0.688

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of SIGLEC1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	6.8	-6.8	0.32
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	7.1	-7.1	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	6.8	-6.8	0.304
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	19	5.9	13.1	0.355
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	37.5	0	37.5	0.209
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	9.1	-1.4	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	10.5	0	10.5	0.135
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	13.6	0	13.6	0.279
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	SIGLEC1
Name	sialic acid binding Ig-like lectin 1, sialoadhesin
Aliases	SIGLEC-1; CD169; FLJ00051; FLJ00055; FLJ00073; FLJ32150; dJ1009E24.1; sialoadhesin; sialic acid-binding Ig-l ......
Chromosomal Location	20p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SIGLEC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SIGLEC1
Name	sialic acid binding Ig-like lectin 1, sialoadhesin
Aliases	SIGLEC-1; CD169; FLJ00051; FLJ00055; FLJ00073; FLJ32150; dJ1009E24.1; sialoadhesin; sialic acid-binding Ig-l ......
Chromosomal Location	20p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SIGLEC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SIGLEC1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SIGLEC1
Name	sialic acid binding Ig-like lectin 1, sialoadhesin
Aliases	SIGLEC-1; CD169; FLJ00051; FLJ00055; FLJ00073; FLJ32150; dJ1009E24.1; sialoadhesin; sialic acid-binding Ig-l ......
Chromosomal Location	20p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SIGLEC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SIGLEC1
Name	sialic acid binding Ig-like lectin 1, sialoadhesin
Aliases	SIGLEC-1; CD169; FLJ00051; FLJ00055; FLJ00073; FLJ32150; dJ1009E24.1; sialoadhesin; sialic acid-binding Ig-l ......
Chromosomal Location	20p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SIGLEC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SIGLEC1
Name	sialic acid binding Ig-like lectin 1, sialoadhesin
Aliases	SIGLEC-1; CD169; FLJ00051; FLJ00055; FLJ00073; FLJ32150; dJ1009E24.1; sialoadhesin; sialic acid-binding Ig-l ......
Chromosomal Location	20p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SIGLEC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SIGLEC1
Name	sialic acid binding Ig-like lectin 1, sialoadhesin
Aliases	SIGLEC-1; CD169; FLJ00051; FLJ00055; FLJ00073; FLJ32150; dJ1009E24.1; sialoadhesin; sialic acid-binding Ig-l ......
Chromosomal Location	20p13
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SIGLEC1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting SIGLEC1.

ID	Name	Drug Type	Targets	#Targets
DB02379	Beta-D-Glucose	Small Molecule	AMY1A, AMY2A, AMY2B, GCK, GLT6D1, GNPDA1, HK1, IFNB1, KRTAP5-2, KR ......	22
DB03721	N-acetyl-alpha-neuraminic acid	Small Molecule	AZGP1, CES1, MBL2, REG1A, SELE, SELP, SIGLEC1	7

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