Browse SKAP1

Summary
SymbolSKAP1
Namesrc kinase associated phosphoprotein 1
Aliases SKAP55; SCAP1; src family associated phosphoprotein 1; HEL-S-81p; SKAP-55; epididymis secretory sperm bindin ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm. Nucleus. Cell membrane. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.
Domain PF00169 PH domain
PF00018 SH3 domain
Function

Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.

> Gene Ontology
 
Biological Process GO:0002250 adaptive immune response
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0002757 immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0007009 plasma membrane organization
GO:0045785 positive regulation of cell adhesion
GO:0050851 antigen receptor-mediated signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:1990778 protein localization to cell periphery
Molecular Function GO:0005070 SH3/SH2 adaptor activity
GO:0017124 SH3 domain binding
GO:0019902 phosphatase binding
GO:0019903 protein phosphatase binding
GO:0030674 protein binding, bridging
GO:0035591 signaling adaptor activity
GO:0042169 SH2 domain binding
GO:0060090 binding, bridging
Cellular Component GO:0042101 T cell receptor complex
GO:0043235 receptor complex
GO:0098802 plasma membrane receptor complex
> KEGG and Reactome Pathway
 
KEGG hsa04015 Rap1 signaling pathway
Reactome -
Summary
SymbolSKAP1
Namesrc kinase associated phosphoprotein 1
Aliases SKAP55; SCAP1; src family associated phosphoprotein 1; HEL-S-81p; SKAP-55; epididymis secretory sperm bindin ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SKAP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between SKAP1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
25851535MelanomaInhibit immunity (T cell function)Together, we propose that targeting the unrecognized ADAP-SKAP55-NFATc1-PD-1 pathway might increase efficacy of anti-tumor immunotherapy.
Summary
SymbolSKAP1
Namesrc kinase associated phosphoprotein 1
Aliases SKAP55; SCAP1; src family associated phosphoprotein 1; HEL-S-81p; SKAP-55; epididymis secretory sperm bindin ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SKAP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSKAP1
Namesrc kinase associated phosphoprotein 1
Aliases SKAP55; SCAP1; src family associated phosphoprotein 1; HEL-S-81p; SKAP-55; epididymis secretory sperm bindin ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SKAP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.10.877
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.6030.654
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6040.542
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.7730.0559
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.8150.502
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7270.66
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.8660.207
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.9330.0729
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2260.841
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4420.766
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-1.1410.614
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0460.792
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SKAP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.112.5-1.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSKAP1
Namesrc kinase associated phosphoprotein 1
Aliases SKAP55; SCAP1; src family associated phosphoprotein 1; HEL-S-81p; SKAP-55; epididymis secretory sperm bindin ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SKAP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSKAP1
Namesrc kinase associated phosphoprotein 1
Aliases SKAP55; SCAP1; src family associated phosphoprotein 1; HEL-S-81p; SKAP-55; epididymis secretory sperm bindin ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SKAP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SKAP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSKAP1
Namesrc kinase associated phosphoprotein 1
Aliases SKAP55; SCAP1; src family associated phosphoprotein 1; HEL-S-81p; SKAP-55; epididymis secretory sperm bindin ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SKAP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSKAP1
Namesrc kinase associated phosphoprotein 1
Aliases SKAP55; SCAP1; src family associated phosphoprotein 1; HEL-S-81p; SKAP-55; epididymis secretory sperm bindin ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SKAP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSKAP1
Namesrc kinase associated phosphoprotein 1
Aliases SKAP55; SCAP1; src family associated phosphoprotein 1; HEL-S-81p; SKAP-55; epididymis secretory sperm bindin ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SKAP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSKAP1
Namesrc kinase associated phosphoprotein 1
Aliases SKAP55; SCAP1; src family associated phosphoprotein 1; HEL-S-81p; SKAP-55; epididymis secretory sperm bindin ......
Chromosomal Location17q21.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SKAP1 collected from DrugBank database.
> Drugs from DrugBank database
 

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