TISIDB

Summary
Symbol	SLC16A3
Name	solute carrier family 16 (monocarboxylate transporter), member 3
Aliases	solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ......
Chromosomal Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Domain	PF07690 Major Facilitator Superfamily
Function	Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0006090 pyruvate metabolic process GO:0006820 anion transport GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015727 lactate transport GO:0035873 lactate transmembrane transport GO:0035879 plasma membrane lactate transport GO:0046942 carboxylic acid transport GO:0050900 leukocyte migration GO:0098656 anion transmembrane transport
Molecular Function	GO:0005342 organic acid transmembrane transporter activity GO:0008028 monocarboxylic acid transmembrane transporter activity GO:0008509 anion transmembrane transporter activity GO:0008514 organic anion transmembrane transporter activity GO:0015129 lactate transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0022804 active transmembrane transporter activity GO:0046943 carboxylic acid transmembrane transporter activity
Cellular Component	GO:0005635 nuclear envelope GO:0015629 actin cytoskeleton GO:0031965 nuclear membrane

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-210991: Basigin interactions R-HSA-425471: Bile salt and organic anion SLC transporters R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-109582: Hemostasis R-HSA-1430728: Metabolism R-HSA-433692: Proton-coupled monocarboxylate transport R-HSA-70268: Pyruvate metabolism R-HSA-71406: Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-425407: SLC-mediated transmembrane transport R-HSA-1428517: The citric acid (TCA) cycle and respiratory electron transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

> KEGG and Reactome Pathway

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KEGG

Reactome

R-HSA-210991: Basigin interactions
R-HSA-425471: Bile salt and organic anion SLC transporters
R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-109582: Hemostasis
R-HSA-1430728: Metabolism
R-HSA-433692: Proton-coupled monocarboxylate transport
R-HSA-70268: Pyruvate metabolism
R-HSA-71406: Pyruvate metabolism and Citric Acid (TCA) cycle
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-1428517: The citric acid (TCA) cycle and respiratory electron transport
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

Summary
Symbol	SLC16A3
Name	solute carrier family 16 (monocarboxylate transporter), member 3
Aliases	solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ......
Chromosomal Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SLC16A3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	SLC16A3
Name	solute carrier family 16 (monocarboxylate transporter), member 3
Aliases	solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ......
Chromosomal Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of SLC16A3 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SLC16A3
Name	solute carrier family 16 (monocarboxylate transporter), member 3
Aliases	solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ......
Chromosomal Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of SLC16A3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-1.801	0.00136
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-2.226	0.418
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-1.478	0.425
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.06	0.922
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.124	0.956
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.015	0.996
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.077	0.905
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.348	0.824
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.261	0.876
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.816	0.733
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.416	0.91
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.14	0.289

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of SLC16A3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	5.9	-5.9	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	7.1	-7.1	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	0	7.4	0.0709
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	0	7.4	0.096
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	5.9	-5.9	0.447
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	9.1	-9.1	0.458
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	6.2	4.9	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	11.1	8.9	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	SLC16A3
Name	solute carrier family 16 (monocarboxylate transporter), member 3
Aliases	solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ......
Chromosomal Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC16A3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SLC16A3
Name	solute carrier family 16 (monocarboxylate transporter), member 3
Aliases	solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ......
Chromosomal Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC16A3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC16A3. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SLC16A3
Name	solute carrier family 16 (monocarboxylate transporter), member 3
Aliases	solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ......
Chromosomal Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC16A3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SLC16A3
Name	solute carrier family 16 (monocarboxylate transporter), member 3
Aliases	solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ......
Chromosomal Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SLC16A3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SLC16A3
Name	solute carrier family 16 (monocarboxylate transporter), member 3
Aliases	solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ......
Chromosomal Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SLC16A3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SLC16A3
Name	solute carrier family 16 (monocarboxylate transporter), member 3
Aliases	solute carrier family 16 (monocarboxylic acid transporters), member 3; solute carrier family 16, member 3 (m ......
Chromosomal Location	17q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SLC16A3 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting SLC16A3.

ID	Name	Drug Type	Targets	#Targets
DB00119	Pyruvic acid	Small Molecule	ABAT, AGXT2, PC, PDHB, PKLR, PKM, SLC16A1, SLC16A2, SLC16A3, SLC16 ......	14

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