TISIDB

Summary
Symbol	SLC22A3
Name	solute carrier family 22 (organic cation transporter), member 3
Aliases	solute carrier family 22 (extraneuronal monoamine transporter), member 3; EMTH; EMT organic cation transport ......
Chromosomal Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane; Multi-pass membrane protein.
Domain	PF07690 Major Facilitator Superfamily
Function	Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain.

> Gene Ontology [ TOP ]
Biological Process	GO:0001504 neurotransmitter uptake GO:0001505 regulation of neurotransmitter levels GO:0006836 neurotransmitter transport GO:0006855 drug transmembrane transport GO:0009991 response to extracellular stimulus GO:0015695 organic cation transport GO:0015697 quaternary ammonium group transport GO:0015844 monoamine transport GO:0015850 organic hydroxy compound transport GO:0015872 dopamine transport GO:0015893 drug transport GO:0031667 response to nutrient levels GO:0032098 regulation of appetite GO:0042493 response to drug GO:0045117 azole transport GO:0051608 histamine transport GO:0051615 histamine uptake GO:0051937 catecholamine transport GO:0098657 import into cell GO:1901998 toxin transport
Molecular Function	GO:0005329 dopamine transmembrane transporter activity GO:0008504 monoamine transmembrane transporter activity GO:0015101 organic cation transmembrane transporter activity GO:0015651 quaternary ammonium group transmembrane transporter activity GO:0019534 toxin transporter activity GO:0022804 active transmembrane transporter activity GO:1901618 organic hydroxy compound transmembrane transporter activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-2161517: Abacavir transmembrane transport R-HSA-2161522: Abacavir transport and metabolism R-HSA-1430728: Metabolism R-HSA-549127: Organic cation transport R-HSA-549132: Organic cation/anion/zwitterion transport R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

> KEGG and Reactome Pathway

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KEGG

Reactome

R-HSA-2161517: Abacavir transmembrane transport
R-HSA-2161522: Abacavir transport and metabolism
R-HSA-1430728: Metabolism
R-HSA-549127: Organic cation transport
R-HSA-549132: Organic cation/anion/zwitterion transport
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

Summary
Symbol	SLC22A3
Name	solute carrier family 22 (organic cation transporter), member 3
Aliases	solute carrier family 22 (extraneuronal monoamine transporter), member 3; EMTH; EMT organic cation transport ......
Chromosomal Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SLC22A3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	SLC22A3
Name	solute carrier family 22 (organic cation transporter), member 3
Aliases	solute carrier family 22 (extraneuronal monoamine transporter), member 3; EMTH; EMT organic cation transport ......
Chromosomal Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of SLC22A3 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SLC22A3
Name	solute carrier family 22 (organic cation transporter), member 3
Aliases	solute carrier family 22 (extraneuronal monoamine transporter), member 3; EMTH; EMT organic cation transport ......
Chromosomal Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of SLC22A3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.003	0.996
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.351	0.702
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.278	0.709
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.91	0.125
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-1.099	0.489
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.672	0.728
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.616	0.448
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	1.202	0.306
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.071	0.955
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.379	0.723
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.724	0.585
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.99	0.00149

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of SLC22A3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	2.7	-2.7	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	3.4	-3.4	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	SLC22A3
Name	solute carrier family 22 (organic cation transporter), member 3
Aliases	solute carrier family 22 (extraneuronal monoamine transporter), member 3; EMTH; EMT organic cation transport ......
Chromosomal Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC22A3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SLC22A3
Name	solute carrier family 22 (organic cation transporter), member 3
Aliases	solute carrier family 22 (extraneuronal monoamine transporter), member 3; EMTH; EMT organic cation transport ......
Chromosomal Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC22A3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC22A3. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SLC22A3
Name	solute carrier family 22 (organic cation transporter), member 3
Aliases	solute carrier family 22 (extraneuronal monoamine transporter), member 3; EMTH; EMT organic cation transport ......
Chromosomal Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC22A3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SLC22A3
Name	solute carrier family 22 (organic cation transporter), member 3
Aliases	solute carrier family 22 (extraneuronal monoamine transporter), member 3; EMTH; EMT organic cation transport ......
Chromosomal Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SLC22A3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SLC22A3
Name	solute carrier family 22 (organic cation transporter), member 3
Aliases	solute carrier family 22 (extraneuronal monoamine transporter), member 3; EMTH; EMT organic cation transport ......
Chromosomal Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SLC22A3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SLC22A3
Name	solute carrier family 22 (organic cation transporter), member 3
Aliases	solute carrier family 22 (extraneuronal monoamine transporter), member 3; EMTH; EMT organic cation transport ......
Chromosomal Location	6q25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SLC22A3 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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