Browse SLC25A29

Summary
SymbolSLC25A29
Namesolute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
Aliases FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ......
Chromosomal Location14q32.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion inner membrane Multi-pass membrane protein
Domain PF00153 Mitochondrial carrier protein
Function

Transports arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine (PubMed:24652292). Can restore ornithine transport in cells lacking the primary mitochondrial ornithine transporter SLC25A15 (PubMed:19287344). Does not transport carnitine nor acylcarnitines (PubMed:24652292). Functions by both counter-exchange and uniport mechanisms (PubMed:24652292).

> Gene Ontology
 
Biological Process GO:0006844 acyl carnitine transport
GO:0015697 quaternary ammonium group transport
GO:0051181 cofactor transport
GO:1902616 acyl carnitine transmembrane transport
Molecular Function GO:0003735 structural constituent of ribosome
GO:0015101 organic cation transmembrane transporter activity
GO:0015227 acyl carnitine transmembrane transporter activity
GO:0015651 quaternary ammonium group transmembrane transporter activity
Cellular Component GO:0005743 mitochondrial inner membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolSLC25A29
Namesolute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
Aliases FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ......
Chromosomal Location14q32.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SLC25A29 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSLC25A29
Namesolute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
Aliases FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ......
Chromosomal Location14q32.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SLC25A29 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSLC25A29
Namesolute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
Aliases FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ......
Chromosomal Location14q32.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SLC25A29 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0780.791
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0640.969
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0970.942
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.9070.0369
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.0630.617
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7080.785
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3920.212
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2940.799
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4660.703
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.50.73
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2170.523
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1740.162
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolSLC25A29
Namesolute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
Aliases FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ......
Chromosomal Location14q32.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC25A29. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSLC25A29
Namesolute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
Aliases FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ......
Chromosomal Location14q32.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC25A29. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC25A29.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSLC25A29
Namesolute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
Aliases FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ......
Chromosomal Location14q32.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC25A29. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSLC25A29
Namesolute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
Aliases FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ......
Chromosomal Location14q32.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SLC25A29 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSLC25A29
Namesolute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
Aliases FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ......
Chromosomal Location14q32.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SLC25A29 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSLC25A29
Namesolute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29
Aliases FLJ38975; C14orf69; chromosome 14 open reading frame 69; solute carrier family 25, member 29; CACL; ORNT3; c ......
Chromosomal Location14q32.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SLC25A29 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting SLC25A29.
ID Name Drug Type Targets #Targets
DB00583L-CarnitineSmall MoleculeCES1, CPT1A, CPT2, CRAT, CROT, MPO, SLC22A4, SLC22A5, SLC25A20, SL ......11