Summary | |
---|---|
Symbol | SLC2A3 |
Name | solute carrier family 2 (facilitated glucose transporter), member 3 |
Aliases | GLUT3; GLUT-3; glucose transporter type 3, brain; Solute carrier family 2, facilitated glucose transporter m ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein |
Domain |
PF00083 Sugar (and other) transporter |
Function |
Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916). |
Biological Process |
GO:0006766 vitamin metabolic process GO:0006767 water-soluble vitamin metabolic process GO:0006820 anion transport GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0015711 organic anion transport GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0019852 L-ascorbic acid metabolic process GO:0034219 carbohydrate transmembrane transport GO:0035428 hexose transmembrane transport GO:0051180 vitamin transport GO:0070837 dehydroascorbic acid transport GO:1904659 glucose transmembrane transport |
Molecular Function |
GO:0005355 glucose transmembrane transporter activity GO:0005536 glucose binding GO:0015144 carbohydrate transmembrane transporter activity GO:0015145 monosaccharide transmembrane transporter activity GO:0015149 hexose transmembrane transporter activity GO:0030246 carbohydrate binding GO:0033300 dehydroascorbic acid transporter activity GO:0048029 monosaccharide binding GO:0051119 sugar transmembrane transporter activity GO:0051183 vitamin transporter activity GO:0055056 D-glucose transmembrane transporter activity GO:1901476 carbohydrate transporter activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-428790: Facilitative Na+-independent glucose transporters R-HSA-70153: Glucose transport R-HSA-189200: Hexose transport R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates R-HSA-196854: Metabolism of vitamins and cofactors R-HSA-196849: Metabolism of water-soluble vitamins and cofactors R-HSA-6798695: Neutrophil degranulation R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds R-HSA-196836: Vitamin C (ascorbate) metabolism |
Summary | |
---|---|
Symbol | SLC2A3 |
Name | solute carrier family 2 (facilitated glucose transporter), member 3 |
Aliases | GLUT3; GLUT-3; glucose transporter type 3, brain; Solute carrier family 2, facilitated glucose transporter m ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SLC2A3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SLC2A3 |
Name | solute carrier family 2 (facilitated glucose transporter), member 3 |
Aliases | GLUT3; GLUT-3; glucose transporter type 3, brain; Solute carrier family 2, facilitated glucose transporter m ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of SLC2A3 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | SLC2A3 |
Name | solute carrier family 2 (facilitated glucose transporter), member 3 |
Aliases | GLUT3; GLUT-3; glucose transporter type 3, brain; Solute carrier family 2, facilitated glucose transporter m ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SLC2A3 in various data sets.
|
Points in the above scatter plot represent the mutation difference of SLC2A3 in various data sets.
|
Summary | |
---|---|
Symbol | SLC2A3 |
Name | solute carrier family 2 (facilitated glucose transporter), member 3 |
Aliases | GLUT3; GLUT-3; glucose transporter type 3, brain; Solute carrier family 2, facilitated glucose transporter m ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC2A3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SLC2A3 |
Name | solute carrier family 2 (facilitated glucose transporter), member 3 |
Aliases | GLUT3; GLUT-3; glucose transporter type 3, brain; Solute carrier family 2, facilitated glucose transporter m ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC2A3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC2A3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SLC2A3 |
Name | solute carrier family 2 (facilitated glucose transporter), member 3 |
Aliases | GLUT3; GLUT-3; glucose transporter type 3, brain; Solute carrier family 2, facilitated glucose transporter m ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC2A3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SLC2A3 |
Name | solute carrier family 2 (facilitated glucose transporter), member 3 |
Aliases | GLUT3; GLUT-3; glucose transporter type 3, brain; Solute carrier family 2, facilitated glucose transporter m ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SLC2A3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SLC2A3 |
Name | solute carrier family 2 (facilitated glucose transporter), member 3 |
Aliases | GLUT3; GLUT-3; glucose transporter type 3, brain; Solute carrier family 2, facilitated glucose transporter m ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SLC2A3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SLC2A3 |
Name | solute carrier family 2 (facilitated glucose transporter), member 3 |
Aliases | GLUT3; GLUT-3; glucose transporter type 3, brain; Solute carrier family 2, facilitated glucose transporter m ...... |
Chromosomal Location | 12p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SLC2A3 collected from DrugBank database. |
There is no record. |