TISIDB

Summary
Symbol	SLC30A4
Name	solute carrier family 30 (zinc transporter), member 4
Aliases	ZNT4; solute carrier family 30 member 4; znT-4; Zinc transporter 4
Chromosomal Location	15q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Endosome membrane Multi-pass membrane protein Late endosome membrane Multi-pass membrane protein Lysosome membrane Multi-pass membrane protein
Domain	PF01545 Cation efflux family
Function	Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.

> Gene Ontology [ TOP ]
Biological Process	GO:0000041 transition metal ion transport GO:0006829 zinc II ion transport GO:0006875 cellular metal ion homeostasis GO:0006882 cellular zinc ion homeostasis GO:0009636 response to toxic substance GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010043 response to zinc ion GO:0032119 sequestering of zinc ion GO:0032844 regulation of homeostatic process GO:0046916 cellular transition metal ion homeostasis GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0055069 zinc ion homeostasis GO:0055076 transition metal ion homeostasis GO:0061088 regulation of sequestering of zinc ion GO:0070838 divalent metal ion transport GO:0071577 zinc II ion transmembrane transport GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:1990267 response to transition metal nanoparticle GO:2000021 regulation of ion homeostasis
Molecular Function	GO:0005385 zinc ion transmembrane transporter activity GO:0046873 metal ion transmembrane transporter activity GO:0046915 transition metal ion transmembrane transporter activity GO:0072509 divalent inorganic cation transmembrane transporter activity
Cellular Component	GO:0005765 lysosomal membrane GO:0005770 late endosome GO:0010008 endosome membrane GO:0031902 late endosome membrane GO:0044440 endosomal part GO:0098852 lytic vacuole membrane

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	SLC30A4
Name	solute carrier family 30 (zinc transporter), member 4
Aliases	ZNT4; solute carrier family 30 member 4; znT-4; Zinc transporter 4
Chromosomal Location	15q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SLC30A4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	SLC30A4
Name	solute carrier family 30 (zinc transporter), member 4
Aliases	ZNT4; solute carrier family 30 member 4; znT-4; Zinc transporter 4
Chromosomal Location	15q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of SLC30A4 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SLC30A4
Name	solute carrier family 30 (zinc transporter), member 4
Aliases	ZNT4; solute carrier family 30 member 4; znT-4; Zinc transporter 4
Chromosomal Location	15q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of SLC30A4 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.078	0.756
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.288	0.57
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.073	0.858
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.934	0.0458
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.815	0.643
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-1.078	0.649
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.17	0.582
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.396	0.623
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.022	0.978
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.5	0.387
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.766	0.348
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.041	0.788

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of SLC30A4 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	1.4	-1.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	1.7	-1.7	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	SLC30A4
Name	solute carrier family 30 (zinc transporter), member 4
Aliases	ZNT4; solute carrier family 30 member 4; znT-4; Zinc transporter 4
Chromosomal Location	15q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC30A4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SLC30A4
Name	solute carrier family 30 (zinc transporter), member 4
Aliases	ZNT4; solute carrier family 30 member 4; znT-4; Zinc transporter 4
Chromosomal Location	15q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC30A4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC30A4. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SLC30A4
Name	solute carrier family 30 (zinc transporter), member 4
Aliases	ZNT4; solute carrier family 30 member 4; znT-4; Zinc transporter 4
Chromosomal Location	15q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC30A4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SLC30A4
Name	solute carrier family 30 (zinc transporter), member 4
Aliases	ZNT4; solute carrier family 30 member 4; znT-4; Zinc transporter 4
Chromosomal Location	15q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SLC30A4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SLC30A4
Name	solute carrier family 30 (zinc transporter), member 4
Aliases	ZNT4; solute carrier family 30 member 4; znT-4; Zinc transporter 4
Chromosomal Location	15q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SLC30A4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SLC30A4
Name	solute carrier family 30 (zinc transporter), member 4
Aliases	ZNT4; solute carrier family 30 member 4; znT-4; Zinc transporter 4
Chromosomal Location	15q21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SLC30A4 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse SLC30A4