TISIDB

Summary
Symbol	SLC34A2
Name	solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
Aliases	NAPI-3B; solute carrier family 34 (sodium phosphate), member 2; NAPI-IIb; NPTIIb; sodium/phosphate cotranspo ......
Chromosomal Location	4p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane; Multi-pass membrane protein.
Domain	PF02690 Na+/Pi-cotransporter
Function	May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli.

> Gene Ontology [ TOP ]
Biological Process	GO:0001701 in utero embryonic development GO:0006814 sodium ion transport GO:0006817 phosphate ion transport GO:0006820 anion transport GO:0015672 monovalent inorganic cation transport GO:0015698 inorganic anion transport GO:0030002 cellular anion homeostasis GO:0030643 cellular phosphate ion homeostasis GO:0035435 phosphate ion transmembrane transport GO:0035725 sodium ion transmembrane transport GO:0043627 response to estrogen GO:0044341 sodium-dependent phosphate transport GO:0055062 phosphate ion homeostasis GO:0055081 anion homeostasis GO:0072502 cellular trivalent inorganic anion homeostasis GO:0072506 trivalent inorganic anion homeostasis GO:0098656 anion transmembrane transport GO:0098661 inorganic anion transmembrane transport
Molecular Function	GO:0005315 inorganic phosphate transmembrane transporter activity GO:0005436 sodium:phosphate symporter activity GO:0008509 anion transmembrane transporter activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015081 sodium ion transmembrane transporter activity GO:0015103 inorganic anion transmembrane transporter activity GO:0015114 phosphate ion transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015294 solute:cation symporter activity GO:0015296 anion:cation symporter activity GO:0015321 sodium-dependent phosphate transmembrane transporter activity GO:0022804 active transmembrane transporter activity GO:0022853 active ion transmembrane transporter activity GO:0031402 sodium ion binding GO:0031420 alkali metal ion binding GO:0042301 phosphate ion binding GO:0043168 anion binding GO:0046873 metal ion transmembrane transporter activity GO:1901677 phosphate transmembrane transporter activity
Cellular Component	GO:0005903 brush border GO:0016324 apical plasma membrane GO:0031253 cell projection membrane GO:0031526 brush border membrane GO:0045177 apical part of cell GO:0098862 cluster of actin-based cell projections

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04978 Mineral absorption
Reactome	R-HSA-392499: Metabolism of proteins R-HSA-425407: SLC-mediated transmembrane transport R-HSA-427652: Sodium-coupled phosphate cotransporters R-HSA-5683826: Surfactant metabolism R-HSA-382551: Transmembrane transport of small molecules R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides R-HSA-427589: Type II Na+/Pi cotransporters

Summary
Symbol	SLC34A2
Name	solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
Aliases	NAPI-3B; solute carrier family 34 (sodium phosphate), member 2; NAPI-IIb; NPTIIb; sodium/phosphate cotranspo ......
Chromosomal Location	4p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SLC34A2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	SLC34A2
Name	solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
Aliases	NAPI-3B; solute carrier family 34 (sodium phosphate), member 2; NAPI-IIb; NPTIIb; sodium/phosphate cotranspo ......
Chromosomal Location	4p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of SLC34A2 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SLC34A2
Name	solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
Aliases	NAPI-3B; solute carrier family 34 (sodium phosphate), member 2; NAPI-IIb; NPTIIb; sodium/phosphate cotranspo ......
Chromosomal Location	4p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of SLC34A2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.389	0.465
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-1.266	0.158
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.245	0.741
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.369	0.576
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.121	0.927
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.68	0.662
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.427	0.663
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.695	0.683
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-1.701	0.346
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.3	0.869
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.071	0.977
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-1.105	0.0333

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of SLC34A2 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	5.9	-5.9	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	33.3	-33.3	0.231
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	13.7	-13.7	0.0581
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	16.9	-16.9	0.027
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	11.8	-7	0.577
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	18.2	-10.5	0.576
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	3.7	-1.1	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	7.7	-3.2	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	SLC34A2
Name	solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
Aliases	NAPI-3B; solute carrier family 34 (sodium phosphate), member 2; NAPI-IIb; NPTIIb; sodium/phosphate cotranspo ......
Chromosomal Location	4p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC34A2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SLC34A2
Name	solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
Aliases	NAPI-3B; solute carrier family 34 (sodium phosphate), member 2; NAPI-IIb; NPTIIb; sodium/phosphate cotranspo ......
Chromosomal Location	4p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC34A2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC34A2. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SLC34A2
Name	solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
Aliases	NAPI-3B; solute carrier family 34 (sodium phosphate), member 2; NAPI-IIb; NPTIIb; sodium/phosphate cotranspo ......
Chromosomal Location	4p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC34A2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SLC34A2
Name	solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
Aliases	NAPI-3B; solute carrier family 34 (sodium phosphate), member 2; NAPI-IIb; NPTIIb; sodium/phosphate cotranspo ......
Chromosomal Location	4p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SLC34A2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SLC34A2
Name	solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
Aliases	NAPI-3B; solute carrier family 34 (sodium phosphate), member 2; NAPI-IIb; NPTIIb; sodium/phosphate cotranspo ......
Chromosomal Location	4p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SLC34A2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SLC34A2
Name	solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
Aliases	NAPI-3B; solute carrier family 34 (sodium phosphate), member 2; NAPI-IIb; NPTIIb; sodium/phosphate cotranspo ......
Chromosomal Location	4p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SLC34A2 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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