Browse SLC38A11

Summary
SymbolSLC38A11
Namesolute carrier family 38, member 11
Aliases FLJ39822; AVT2; solute carrier family 38 member 11; Putative sodium-coupled neutral amino acid transporter 1 ......
Chromosomal Location2q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Multi-pass membrane protein
Domain PF01490 Transmembrane amino acid transporter protein
Function

Putative sodium-dependent amino acid/proton antiporter.

> Gene Ontology
 
Biological Process GO:0003333 amino acid transmembrane transport
GO:0006814 sodium ion transport
GO:0006865 amino acid transport
GO:0015672 monovalent inorganic cation transport
GO:0015849 organic acid transport
GO:1903825 organic acid transmembrane transport
GO:1905039 carboxylic acid transmembrane transport
Molecular Function GO:0005342 organic acid transmembrane transporter activity
GO:0015171 amino acid transmembrane transporter activity
GO:0046943 carboxylic acid transmembrane transporter activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolSLC38A11
Namesolute carrier family 38, member 11
Aliases FLJ39822; AVT2; solute carrier family 38 member 11; Putative sodium-coupled neutral amino acid transporter 1 ......
Chromosomal Location2q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SLC38A11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolSLC38A11
Namesolute carrier family 38, member 11
Aliases FLJ39822; AVT2; solute carrier family 38 member 11; Putative sodium-coupled neutral amino acid transporter 1 ......
Chromosomal Location2q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SLC38A11 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSLC38A11
Namesolute carrier family 38, member 11
Aliases FLJ39822; AVT2; solute carrier family 38 member 11; Putative sodium-coupled neutral amino acid transporter 1 ......
Chromosomal Location2q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SLC38A11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0280.958
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.2590.763
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2410.738
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.6820.413
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.0420.516
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2480.875
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.4450.0646
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5860.638
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11122.4190.0635
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0620.939
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2460.213
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.7180.00222
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SLC38A11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSLC38A11
Namesolute carrier family 38, member 11
Aliases FLJ39822; AVT2; solute carrier family 38 member 11; Putative sodium-coupled neutral amino acid transporter 1 ......
Chromosomal Location2q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC38A11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSLC38A11
Namesolute carrier family 38, member 11
Aliases FLJ39822; AVT2; solute carrier family 38 member 11; Putative sodium-coupled neutral amino acid transporter 1 ......
Chromosomal Location2q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC38A11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC38A11.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSLC38A11
Namesolute carrier family 38, member 11
Aliases FLJ39822; AVT2; solute carrier family 38 member 11; Putative sodium-coupled neutral amino acid transporter 1 ......
Chromosomal Location2q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC38A11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSLC38A11
Namesolute carrier family 38, member 11
Aliases FLJ39822; AVT2; solute carrier family 38 member 11; Putative sodium-coupled neutral amino acid transporter 1 ......
Chromosomal Location2q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SLC38A11 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSLC38A11
Namesolute carrier family 38, member 11
Aliases FLJ39822; AVT2; solute carrier family 38 member 11; Putative sodium-coupled neutral amino acid transporter 1 ......
Chromosomal Location2q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SLC38A11 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSLC38A11
Namesolute carrier family 38, member 11
Aliases FLJ39822; AVT2; solute carrier family 38 member 11; Putative sodium-coupled neutral amino acid transporter 1 ......
Chromosomal Location2q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SLC38A11 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.