Browse SLC39A5

Summary
SymbolSLC39A5
Namesolute carrier family 39 (zinc transporter), member 5
Aliases solute carrier family 39 (metal ion transporter), member 5; LZT-Hs7; MYP24; ZIP5; solute carrier family 39 m ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Basolateral cell membrane Multi-pass membrane protein
Domain PF02535 ZIP Zinc transporter
Function

May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status (By similarity).

> Gene Ontology
 
Biological Process GO:0000041 transition metal ion transport
GO:0000375 RNA splicing, via transesterification reactions
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000398 mRNA splicing, via spliceosome
GO:0001654 eye development
GO:0006397 mRNA processing
GO:0006829 zinc II ion transport
GO:0006875 cellular metal ion homeostasis
GO:0006882 cellular zinc ion homeostasis
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007423 sensory organ development
GO:0008380 RNA splicing
GO:0009267 cellular response to starvation
GO:0009991 response to extracellular stimulus
GO:0030509 BMP signaling pathway
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0033120 positive regulation of RNA splicing
GO:0034224 cellular response to zinc ion starvation
GO:0042594 response to starvation
GO:0043484 regulation of RNA splicing
GO:0046916 cellular transition metal ion homeostasis
GO:0048024 regulation of mRNA splicing, via spliceosome
GO:0048026 positive regulation of mRNA splicing, via spliceosome
GO:0050684 regulation of mRNA processing
GO:0050685 positive regulation of mRNA processing
GO:0055069 zinc ion homeostasis
GO:0055076 transition metal ion homeostasis
GO:0061351 neural precursor cell proliferation
GO:0070314 G1 to G0 transition
GO:0070315 G1 to G0 transition involved in cell differentiation
GO:0070838 divalent metal ion transport
GO:0071496 cellular response to external stimulus
GO:0071577 zinc II ion transmembrane transport
GO:0071578 zinc II ion transmembrane import
GO:0071772 response to BMP
GO:0071773 cellular response to BMP stimulus
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:1903311 regulation of mRNA metabolic process
GO:1903313 positive regulation of mRNA metabolic process
Molecular Function GO:0005385 zinc ion transmembrane transporter activity
GO:0046873 metal ion transmembrane transporter activity
GO:0046915 transition metal ion transmembrane transporter activity
GO:0072509 divalent inorganic cation transmembrane transporter activity
Cellular Component GO:0016323 basolateral plasma membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-425410: Metal ion SLC transporters
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
R-HSA-442380: Zinc influx into cells by the SLC39 gene family
R-HSA-435354: Zinc transporters
Summary
SymbolSLC39A5
Namesolute carrier family 39 (zinc transporter), member 5
Aliases solute carrier family 39 (metal ion transporter), member 5; LZT-Hs7; MYP24; ZIP5; solute carrier family 39 m ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SLC39A5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSLC39A5
Namesolute carrier family 39 (zinc transporter), member 5
Aliases solute carrier family 39 (metal ion transporter), member 5; LZT-Hs7; MYP24; ZIP5; solute carrier family 39 m ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SLC39A5 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSLC39A5
Namesolute carrier family 39 (zinc transporter), member 5
Aliases solute carrier family 39 (metal ion transporter), member 5; LZT-Hs7; MYP24; ZIP5; solute carrier family 39 m ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SLC39A5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.5110.231
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0020.997
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.8920.178
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.8050.0433
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.5560.685
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.1160.487
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.4470.547
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5920.674
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.7150.226
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.5820.478
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.260.685
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2390.319
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SLC39A5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSLC39A5
Namesolute carrier family 39 (zinc transporter), member 5
Aliases solute carrier family 39 (metal ion transporter), member 5; LZT-Hs7; MYP24; ZIP5; solute carrier family 39 m ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC39A5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSLC39A5
Namesolute carrier family 39 (zinc transporter), member 5
Aliases solute carrier family 39 (metal ion transporter), member 5; LZT-Hs7; MYP24; ZIP5; solute carrier family 39 m ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC39A5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC39A5.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSLC39A5
Namesolute carrier family 39 (zinc transporter), member 5
Aliases solute carrier family 39 (metal ion transporter), member 5; LZT-Hs7; MYP24; ZIP5; solute carrier family 39 m ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC39A5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSLC39A5
Namesolute carrier family 39 (zinc transporter), member 5
Aliases solute carrier family 39 (metal ion transporter), member 5; LZT-Hs7; MYP24; ZIP5; solute carrier family 39 m ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SLC39A5 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSLC39A5
Namesolute carrier family 39 (zinc transporter), member 5
Aliases solute carrier family 39 (metal ion transporter), member 5; LZT-Hs7; MYP24; ZIP5; solute carrier family 39 m ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SLC39A5 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSLC39A5
Namesolute carrier family 39 (zinc transporter), member 5
Aliases solute carrier family 39 (metal ion transporter), member 5; LZT-Hs7; MYP24; ZIP5; solute carrier family 39 m ......
Chromosomal Location12q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SLC39A5 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.