Browse SLC4A10

Summary
SymbolSLC4A10
Namesolute carrier family 4, sodium bicarbonate transporter, member 10
Aliases NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Multi-pass membrane protein. Note=Localizes to the basolateral membrane.
Domain PF07565 Band 3 cytoplasmic domain
PF00955 HCO3- transporter family
Function

Electrogenic sodium/bicarbonate cotransporter in exchange for intracellular chloride. Plays an important role in regulating intracellular pH (By similarity).

> Gene Ontology
 
Biological Process GO:0006814 sodium ion transport
GO:0006818 hydrogen transport
GO:0006820 anion transport
GO:0006821 chloride transport
GO:0006885 regulation of pH
GO:0007626 locomotory behavior
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0009791 post-embryonic development
GO:0015672 monovalent inorganic cation transport
GO:0015698 inorganic anion transport
GO:0015701 bicarbonate transport
GO:0015711 organic anion transport
GO:0015992 proton transport
GO:0021859 pyramidal neuron differentiation
GO:0021860 pyramidal neuron development
GO:0021872 forebrain generation of neurons
GO:0021879 forebrain neuron differentiation
GO:0021884 forebrain neuron development
GO:0021953 central nervous system neuron differentiation
GO:0021954 central nervous system neuron development
GO:0030004 cellular monovalent inorganic cation homeostasis
GO:0030641 regulation of cellular pH
GO:0030900 forebrain development
GO:0035264 multicellular organism growth
GO:0035640 exploration behavior
GO:0035641 locomotory exploration behavior
GO:0044708 single-organism behavior
GO:0048854 brain morphogenesis
GO:0051453 regulation of intracellular pH
GO:0055067 monovalent inorganic cation homeostasis
GO:0098656 anion transmembrane transport
GO:1902600 hydrogen ion transmembrane transport
Molecular Function GO:0005452 inorganic anion exchanger activity
GO:0008509 anion transmembrane transporter activity
GO:0015103 inorganic anion transmembrane transporter activity
GO:0015291 secondary active transmembrane transporter activity
GO:0015293 symporter activity
GO:0015297 antiporter activity
GO:0015301 anion:anion antiporter activity
GO:0022804 active transmembrane transporter activity
GO:0099516 ion antiporter activity
Cellular Component GO:0016323 basolateral plasma membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0097440 apical dendrite
GO:0097441 basilar dendrite
GO:0097442 CA3 pyramidal cell dendrite
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-425381: Bicarbonate transporters
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides
Summary
SymbolSLC4A10
Namesolute carrier family 4, sodium bicarbonate transporter, member 10
Aliases NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SLC4A10 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSLC4A10
Namesolute carrier family 4, sodium bicarbonate transporter, member 10
Aliases NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SLC4A10 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.5 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSLC4A10
Namesolute carrier family 4, sodium bicarbonate transporter, member 10
Aliases NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SLC4A10 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.6190.308
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6750.638
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.5620.704
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.6030.377
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.2250.315
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0270.983
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1580.7
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.1990.745
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2470.332
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SLC4A10 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.16.84.30.443
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.18.52.60.702
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211723.85.917.90.197
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.19.1140.596
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382713.2013.20.0705
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221322.7022.70.134
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSLC4A10
Namesolute carrier family 4, sodium bicarbonate transporter, member 10
Aliases NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC4A10. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSLC4A10
Namesolute carrier family 4, sodium bicarbonate transporter, member 10
Aliases NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC4A10. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC4A10.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSLC4A10
Namesolute carrier family 4, sodium bicarbonate transporter, member 10
Aliases NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC4A10. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSLC4A10
Namesolute carrier family 4, sodium bicarbonate transporter, member 10
Aliases NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SLC4A10 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSLC4A10
Namesolute carrier family 4, sodium bicarbonate transporter, member 10
Aliases NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SLC4A10 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSLC4A10
Namesolute carrier family 4, sodium bicarbonate transporter, member 10
Aliases NBCn2; NCBE; solute carrier family 4, sodium bicarbonate transporter-like, member 10; solute carrier family ......
Chromosomal Location2q24.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SLC4A10 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.