TISIDB

Summary
Symbol	SLC5A1
Name	solute carrier family 5 (sodium/glucose cotransporter), member 1
Aliases	D22S675; NAGT; sodium/glucose cotransporter 1; SGLT1; Na+/glucose cotransporter 1; high affinity sodium-gluc ......
Chromosomal Location	22q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane; Multi-pass membrane protein.
Domain	PF00474 Sodium
Function	Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.

> Gene Ontology [ TOP ]
Biological Process	GO:0001951 intestinal D-glucose absorption GO:0006814 sodium ion transport GO:0007586 digestion GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0015672 monovalent inorganic cation transport GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0022600 digestive system process GO:0034219 carbohydrate transmembrane transport GO:0035428 hexose transmembrane transport GO:0050892 intestinal absorption GO:1904659 glucose transmembrane transport
Molecular Function	GO:0005355 glucose transmembrane transporter activity GO:0005412 glucose:sodium symporter activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015081 sodium ion transmembrane transporter activity GO:0015144 carbohydrate transmembrane transporter activity GO:0015145 monosaccharide transmembrane transporter activity GO:0015149 hexose transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015294 solute:cation symporter activity GO:0015370 solute:sodium symporter activity GO:0022804 active transmembrane transporter activity GO:0046873 metal ion transmembrane transporter activity GO:0051119 sugar transmembrane transporter activity GO:1901476 carbohydrate transporter activity
Cellular Component	GO:0005903 brush border GO:0016324 apical plasma membrane GO:0031253 cell projection membrane GO:0031526 brush border membrane GO:0045177 apical part of cell GO:0098862 cluster of actin-based cell projections

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04973 Carbohydrate digestion and absorption hsa04976 Bile secretion hsa04978 Mineral absorption
Reactome	R-HSA-189200: Hexose transport R-HSA-429593: Inositol transporters R-HSA-1430728: Metabolism R-HSA-71387: Metabolism of carbohydrates R-HSA-428808: Na+-dependent glucose transporters R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

> KEGG and Reactome Pathway

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KEGG

hsa04973 Carbohydrate digestion and absorption
hsa04976 Bile secretion
hsa04978 Mineral absorption

Reactome

R-HSA-189200: Hexose transport
R-HSA-429593: Inositol transporters
R-HSA-1430728: Metabolism
R-HSA-71387: Metabolism of carbohydrates
R-HSA-428808: Na+-dependent glucose transporters
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

Summary
Symbol	SLC5A1
Name	solute carrier family 5 (sodium/glucose cotransporter), member 1
Aliases	D22S675; NAGT; sodium/glucose cotransporter 1; SGLT1; Na+/glucose cotransporter 1; high affinity sodium-gluc ......
Chromosomal Location	22q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SLC5A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	SLC5A1
Name	solute carrier family 5 (sodium/glucose cotransporter), member 1
Aliases	D22S675; NAGT; sodium/glucose cotransporter 1; SGLT1; Na+/glucose cotransporter 1; high affinity sodium-gluc ......
Chromosomal Location	22q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of SLC5A1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SLC5A1
Name	solute carrier family 5 (sodium/glucose cotransporter), member 1
Aliases	D22S675; NAGT; sodium/glucose cotransporter 1; SGLT1; Na+/glucose cotransporter 1; high affinity sodium-gluc ......
Chromosomal Location	22q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of SLC5A1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.425	0.381
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.006	0.994
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.744	0.309
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-1.023	0.134
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-1.284	0.271
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.696	0.603
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.896	0.292
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-1.108	0.452
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.758	0.619
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.643	0.666
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.252	0.896
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.849	0.0494

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of SLC5A1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	5.9	-5.9	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	33.3	-33.3	0.231
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	1.4	9.7	0.0589
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	1.7	9.4	0.0895
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	11.8	-7	0.577
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	18.2	-18.2	0.199
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	7.4	-4.8	0.565
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	15.4	-10.9	0.541
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	SLC5A1
Name	solute carrier family 5 (sodium/glucose cotransporter), member 1
Aliases	D22S675; NAGT; sodium/glucose cotransporter 1; SGLT1; Na+/glucose cotransporter 1; high affinity sodium-gluc ......
Chromosomal Location	22q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC5A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SLC5A1
Name	solute carrier family 5 (sodium/glucose cotransporter), member 1
Aliases	D22S675; NAGT; sodium/glucose cotransporter 1; SGLT1; Na+/glucose cotransporter 1; high affinity sodium-gluc ......
Chromosomal Location	22q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC5A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC5A1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SLC5A1
Name	solute carrier family 5 (sodium/glucose cotransporter), member 1
Aliases	D22S675; NAGT; sodium/glucose cotransporter 1; SGLT1; Na+/glucose cotransporter 1; high affinity sodium-gluc ......
Chromosomal Location	22q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC5A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SLC5A1
Name	solute carrier family 5 (sodium/glucose cotransporter), member 1
Aliases	D22S675; NAGT; sodium/glucose cotransporter 1; SGLT1; Na+/glucose cotransporter 1; high affinity sodium-gluc ......
Chromosomal Location	22q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SLC5A1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SLC5A1
Name	solute carrier family 5 (sodium/glucose cotransporter), member 1
Aliases	D22S675; NAGT; sodium/glucose cotransporter 1; SGLT1; Na+/glucose cotransporter 1; high affinity sodium-gluc ......
Chromosomal Location	22q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SLC5A1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SLC5A1
Name	solute carrier family 5 (sodium/glucose cotransporter), member 1
Aliases	D22S675; NAGT; sodium/glucose cotransporter 1; SGLT1; Na+/glucose cotransporter 1; high affinity sodium-gluc ......
Chromosomal Location	22q12.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SLC5A1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting SLC5A1.

ID	Name	Drug Type	Targets	#Targets
DB08907	Canagliflozin	Small Molecule	SLC5A1, SLC5A2	2

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