TISIDB

Summary
Symbol	SLC5A5
Name	solute carrier family 5 (sodium/iodide cotransporter), member 5
Aliases	NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ......
Chromosomal Location	19p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane; Multi-pass membrane protein.
Domain	PF00474 Sodium
Function	Mediates iodide uptake in the thyroid gland.

> Gene Ontology [ TOP ]
Biological Process	GO:0006575 cellular modified amino acid metabolic process GO:0006590 thyroid hormone generation GO:0006814 sodium ion transport GO:0006820 anion transport GO:0010817 regulation of hormone levels GO:0014074 response to purine-containing compound GO:0015672 monovalent inorganic cation transport GO:0015698 inorganic anion transport GO:0015705 iodide transport GO:0018958 phenol-containing compound metabolic process GO:0034698 response to gonadotropin GO:0035725 sodium ion transmembrane transport GO:0042403 thyroid hormone metabolic process GO:0042445 hormone metabolic process GO:0046683 response to organophosphorus GO:0051591 response to cAMP GO:0071320 cellular response to cAMP GO:0071371 cellular response to gonadotropin stimulus GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0098656 anion transmembrane transport GO:1901615 organic hydroxy compound metabolic process
Molecular Function	GO:0008507 sodium:iodide symporter activity GO:0008509 anion transmembrane transporter activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015081 sodium ion transmembrane transporter activity GO:0015103 inorganic anion transmembrane transporter activity GO:0015111 iodide transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015294 solute:cation symporter activity GO:0015296 anion:cation symporter activity GO:0015370 solute:sodium symporter activity GO:0015373 monovalent anion:sodium symporter activity GO:0022804 active transmembrane transporter activity GO:0022853 active ion transmembrane transporter activity GO:0046873 metal ion transmembrane transporter activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04918 Thyroid hormone synthesis
Reactome	R-HSA-209776: Amine-derived hormones R-HSA-425374: Amino acid and oligopeptide SLC transporters R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives R-HSA-428643: Organic anion transporters R-HSA-425407: SLC-mediated transmembrane transport R-HSA-209968: Thyroxine biosynthesis R-HSA-382551: Transmembrane transport of small molecules R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04918 Thyroid hormone synthesis

Reactome

R-HSA-209776: Amine-derived hormones
R-HSA-425374: Amino acid and oligopeptide SLC transporters
R-HSA-1430728: Metabolism
R-HSA-71291: Metabolism of amino acids and derivatives
R-HSA-428643: Organic anion transporters
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-209968: Thyroxine biosynthesis
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides

Summary
Symbol	SLC5A5
Name	solute carrier family 5 (sodium/iodide cotransporter), member 5
Aliases	NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ......
Chromosomal Location	19p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SLC5A5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between SLC5A5 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
21608083	Breast Carcinoma	Promote immunity	Tumor bearing animals received an intravenous or intratumoral injection of NIS expressing MSCs (MSC-NIS), followed by (99m) Technetium pertechnetate imaging 3-14 days later using a BazookaSPECT γ-camera. Based on imaging/biodistribution data, animals received a therapeutic dose of (131) I 14 days after MSC-NIS injection. This resulted in a significant reduction in tumor growth (mean ± SEM, 236 ± 62 mm(3) vs. 665 ± 204 mm(3) in controls).

Summary
Symbol	SLC5A5
Name	solute carrier family 5 (sodium/iodide cotransporter), member 5
Aliases	NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ......
Chromosomal Location	19p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of SLC5A5 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SLC5A5
Name	solute carrier family 5 (sodium/iodide cotransporter), member 5
Aliases	NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ......
Chromosomal Location	19p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of SLC5A5 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0	1
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0	1
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0	1
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.182	0.724
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.058	0.952
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.491	0.682
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	1.25	0.115
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	1.198	0.457
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	1.181	0.462
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.363	0.413
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0	1
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.138	0.686

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of SLC5A5 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	5.9	-5.9	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	33.3	-33.3	0.231
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	0	3.7	0.27
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	0	3.7	0.314
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	33.3	0	33.3	0.0365
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	0	20	0.357
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	50	0	50	0.109
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	5.3	0	5.3	0.507
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	12.5	0	12.5	0.485
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	SLC5A5
Name	solute carrier family 5 (sodium/iodide cotransporter), member 5
Aliases	NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ......
Chromosomal Location	19p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC5A5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SLC5A5
Name	solute carrier family 5 (sodium/iodide cotransporter), member 5
Aliases	NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ......
Chromosomal Location	19p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC5A5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC5A5. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SLC5A5
Name	solute carrier family 5 (sodium/iodide cotransporter), member 5
Aliases	NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ......
Chromosomal Location	19p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC5A5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SLC5A5
Name	solute carrier family 5 (sodium/iodide cotransporter), member 5
Aliases	NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ......
Chromosomal Location	19p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SLC5A5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SLC5A5
Name	solute carrier family 5 (sodium/iodide cotransporter), member 5
Aliases	NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ......
Chromosomal Location	19p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SLC5A5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SLC5A5
Name	solute carrier family 5 (sodium/iodide cotransporter), member 5
Aliases	NIS; solute carrier family 5 (sodium iodide symporter), member 5; TDH1; Na(+)/I(-) cotransporter; Na(+)/I(-) ......
Chromosomal Location	19p13.11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SLC5A5 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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