TISIDB

Summary
Symbol	SLC6A1
Name	solute carrier family 6 (neurotransmitter transporter), member 1
Aliases	GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location	3p25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity).
Domain	PF00209 Sodium
Function	Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

> Gene Ontology [ TOP ]
Biological Process	GO:0006820 anion transport GO:0006836 neurotransmitter transport GO:0006865 amino acid transport GO:0007270 neuron-neuron synaptic transmission GO:0007611 learning or memory GO:0007612 learning GO:0009636 response to toxic substance GO:0009743 response to carbohydrate GO:0009744 response to sucrose GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010288 response to lead ion GO:0014051 gamma-aminobutyric acid secretion GO:0014052 regulation of gamma-aminobutyric acid secretion GO:0014054 positive regulation of gamma-aminobutyric acid secretion GO:0014074 response to purine-containing compound GO:0015711 organic anion transport GO:0015800 acidic amino acid transport GO:0015812 gamma-aminobutyric acid transport GO:0015849 organic acid transport GO:0032228 regulation of synaptic transmission, GABAergic GO:0032229 negative regulation of synaptic transmission, GABAergic GO:0032355 response to estradiol GO:0034285 response to disaccharide GO:0042220 response to cocaine GO:0043270 positive regulation of ion transport GO:0043279 response to alkaloid GO:0044070 regulation of anion transport GO:0044708 single-organism behavior GO:0046717 acid secretion GO:0046942 carboxylic acid transport GO:0050804 modulation of synaptic transmission GO:0050805 negative regulation of synaptic transmission GO:0050890 cognition GO:0051047 positive regulation of secretion GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051592 response to calcium ion GO:0051932 synaptic transmission, GABAergic GO:0051939 gamma-aminobutyric acid import GO:1903793 positive regulation of anion transport
Molecular Function	GO:0005283 sodium:amino acid symporter activity GO:0005326 neurotransmitter transporter activity GO:0005328 neurotransmitter:sodium symporter activity GO:0005332 gamma-aminobutyric acid:sodium symporter activity GO:0005342 organic acid transmembrane transporter activity GO:0005343 organic acid:sodium symporter activity GO:0005416 cation:amino acid symporter activity GO:0008028 monocarboxylic acid transmembrane transporter activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015081 sodium ion transmembrane transporter activity GO:0015171 amino acid transmembrane transporter activity GO:0015185 gamma-aminobutyric acid transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0015293 symporter activity GO:0015294 solute:cation symporter activity GO:0015370 solute:sodium symporter activity GO:0022804 active transmembrane transporter activity GO:0046873 metal ion transmembrane transporter activity GO:0046943 carboxylic acid transmembrane transporter activity
Cellular Component	GO:0030424 axon

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04727 GABAergic synapse
Reactome	R-HSA-425428: Amine compound SLC transporters R-HSA-888590: GABA synthesis, release, reuptake and degradation R-HSA-442660: Na+/Cl- dependent neurotransmitter transporters R-HSA-112316: Neuronal System R-HSA-112310: Neurotransmitter Release Cycle R-HSA-888593: Reuptake of GABA R-HSA-425407: SLC-mediated transmembrane transport R-HSA-382551: Transmembrane transport of small molecules R-HSA-112315: Transmission across Chemical Synapses R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

> KEGG and Reactome Pathway

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KEGG

hsa04727 GABAergic synapse

Reactome

R-HSA-425428: Amine compound SLC transporters
R-HSA-888590: GABA synthesis, release, reuptake and degradation
R-HSA-442660: Na+/Cl- dependent neurotransmitter transporters
R-HSA-112316: Neuronal System
R-HSA-112310: Neurotransmitter Release Cycle
R-HSA-888593: Reuptake of GABA
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-112315: Transmission across Chemical Synapses
R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds

Summary
Symbol	SLC6A1
Name	solute carrier family 6 (neurotransmitter transporter), member 1
Aliases	GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location	3p25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SLC6A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	SLC6A1
Name	solute carrier family 6 (neurotransmitter transporter), member 1
Aliases	GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location	3p25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of SLC6A1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SLC6A1
Name	solute carrier family 6 (neurotransmitter transporter), member 1
Aliases	GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location	3p25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of SLC6A1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.128	0.739
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.498	0.431
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.592	0.285
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.818	0.144
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-1.347	0.28
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.161	0.901
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.032	0.961
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.073	0.94
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.057	0.956
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.14	0.876
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.955	0.389
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.616	9.61e-05

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of SLC6A1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	2.7	1	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	3.4	0.3	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	9.5	17.6	-8.1	0.64
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	16.7	-4.2	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	18.2	-10.5	0.576
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	7.9	0	7.9	0.26
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	13.6	0	13.6	0.279
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	SLC6A1
Name	solute carrier family 6 (neurotransmitter transporter), member 1
Aliases	GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location	3p25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC6A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SLC6A1
Name	solute carrier family 6 (neurotransmitter transporter), member 1
Aliases	GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location	3p25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC6A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC6A1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SLC6A1
Name	solute carrier family 6 (neurotransmitter transporter), member 1
Aliases	GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location	3p25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC6A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SLC6A1
Name	solute carrier family 6 (neurotransmitter transporter), member 1
Aliases	GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location	3p25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SLC6A1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SLC6A1
Name	solute carrier family 6 (neurotransmitter transporter), member 1
Aliases	GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location	3p25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SLC6A1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SLC6A1
Name	solute carrier family 6 (neurotransmitter transporter), member 1
Aliases	GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location	3p25.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SLC6A1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting SLC6A1.

ID	Name	Drug Type	Targets	#Targets
DB00906	Tiagabine	Small Molecule	SLC6A1	1
DB08848	Guvacine	Small Molecule	SLC6A1, SLC6A11, SLC6A12, SLC6A13	4

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