Browse SLC7A11

Summary
SymbolSLC7A11
Namesolute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Aliases xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ......
Chromosomal Location4q28.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane Multi-pass membrane protein
Domain PF13520 Amino acid permease
Function

Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.

> Gene Ontology
 
Biological Process GO:0001654 eye development
GO:0002088 lens development in camera-type eye
GO:0003333 amino acid transmembrane transport
GO:0006820 anion transport
GO:0006835 dicarboxylic acid transport
GO:0006865 amino acid transport
GO:0006979 response to oxidative stress
GO:0007423 sensory organ development
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0009636 response to toxic substance
GO:0015711 organic anion transport
GO:0015800 acidic amino acid transport
GO:0015807 L-amino acid transport
GO:0015813 L-glutamate transport
GO:0015849 organic acid transport
GO:0030168 platelet activation
GO:0034109 homotypic cell-cell adhesion
GO:0035094 response to nicotine
GO:0043010 camera-type eye development
GO:0043279 response to alkaloid
GO:0046942 carboxylic acid transport
GO:0050817 coagulation
GO:0050878 regulation of body fluid levels
GO:0050900 leukocyte migration
GO:0070306 lens fiber cell differentiation
GO:0070527 platelet aggregation
GO:0089711 L-glutamate transmembrane transport
GO:0098656 anion transmembrane transport
GO:1903825 organic acid transmembrane transport
GO:1905039 carboxylic acid transmembrane transport
Molecular Function GO:0000099 sulfur amino acid transmembrane transporter activity
GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity
GO:0005313 L-glutamate transmembrane transporter activity
GO:0005342 organic acid transmembrane transporter activity
GO:0008509 anion transmembrane transporter activity
GO:0008514 organic anion transmembrane transporter activity
GO:0015171 amino acid transmembrane transporter activity
GO:0015172 acidic amino acid transmembrane transporter activity
GO:0015175 neutral amino acid transmembrane transporter activity
GO:0015291 secondary active transmembrane transporter activity
GO:0015297 antiporter activity
GO:0015327 cystine:glutamate antiporter activity
GO:0015328 cystine secondary active transmembrane transporter activity
GO:0022804 active transmembrane transporter activity
GO:0046943 carboxylic acid transmembrane transporter activity
GO:0072349 modified amino acid transmembrane transporter activity
GO:1901680 sulfur-containing amino acid secondary active transmembrane transporter activity
GO:1901682 sulfur compound transmembrane transporter activity
Cellular Component GO:0005791 rough endoplasmic reticulum
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-425374: Amino acid and oligopeptide SLC transporters
R-HSA-352230: Amino acid transport across the plasma membrane
R-HSA-210991: Basigin interactions
R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-109582: Hemostasis
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides
Summary
SymbolSLC7A11
Namesolute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Aliases xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ......
Chromosomal Location4q28.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SLC7A11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSLC7A11
Namesolute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Aliases xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ......
Chromosomal Location4q28.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SLC7A11 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.73; FDR: 0.01650 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSLC7A11
Namesolute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Aliases xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ......
Chromosomal Location4q28.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SLC7A11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3430.517
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3160.737
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.8260.291
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1430.687
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1780.888
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0980.95
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.5460.477
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2460.857
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11121.4650.31
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1150.802
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3530.568
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0590.79
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SLC7A11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221307.7-7.70.371
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSLC7A11
Namesolute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Aliases xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ......
Chromosomal Location4q28.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC7A11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSLC7A11
Namesolute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Aliases xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ......
Chromosomal Location4q28.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC7A11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC7A11.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSLC7A11
Namesolute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Aliases xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ......
Chromosomal Location4q28.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC7A11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSLC7A11
Namesolute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Aliases xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ......
Chromosomal Location4q28.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SLC7A11 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSLC7A11
Namesolute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Aliases xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ......
Chromosomal Location4q28.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SLC7A11 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSLC7A11
Namesolute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Aliases xCT; CCBR1; amino acid transport system xc-; calcium channel blocker resistance protein CCBR1; solute carrie ......
Chromosomal Location4q28.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SLC7A11 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting SLC7A11.
ID Name Drug Type Targets #Targets
DB00138CystineSmall MoleculeCTNS, SLC3A1, SLC7A11, SLC7A94
DB00142Glutamic AcidSmall MoleculeAADAT, AASS, ABAT, ALDH18A1, ASNS, BCAT1, BCAT2, CCBL2, CPQ, DNPEP ......69
DB00740RiluzoleSmall MoleculeSCN5A, SLC7A112
DB00795SulfasalazineSmall MoleculeACAT1, ALOX5, CHUK, IKBKB, PLA2G1B, PPARG, PTGS1, PTGS2, SLC7A11, ......10
DB06151AcetylcysteineSmall MoleculeACY1, CHUK, GRIN1, GRIN2A, GRIN2B, GRIN2D, GRIN3A, GSS, IKBKB, SLC ......10
DB11590ThimerosalSmall MoleculeFXYD2, MTR, SLC7A113