Browse SMAD4

Summary
SymbolSMAD4
NameSMAD family member 4
Aliases DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ......
Chromosomal Location18q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R-SMAD (PubMed:15799969). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236).
Domain PF03165 MH1 domain
PF03166 MH2 domain
Function

In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

> Gene Ontology
 
Biological Process GO:0000578 embryonic axis specification
GO:0001541 ovarian follicle development
GO:0001558 regulation of cell growth
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001702 gastrulation with mouth forming second
GO:0001756 somitogenesis
GO:0001763 morphogenesis of a branching structure
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0001837 epithelial to mesenchymal transition
GO:0001933 negative regulation of protein phosphorylation
GO:0001942 hair follicle development
GO:0003002 regionalization
GO:0003007 heart morphogenesis
GO:0003012 muscle system process
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003157 endocardium development
GO:0003158 endothelium development
GO:0003170 heart valve development
GO:0003171 atrioventricular valve development
GO:0003179 heart valve morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003188 heart valve formation
GO:0003190 atrioventricular valve formation
GO:0003197 endocardial cushion development
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203 endocardial cushion morphogenesis
GO:0003205 cardiac chamber development
GO:0003206 cardiac chamber morphogenesis
GO:0003208 cardiac ventricle morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0003220 left ventricular cardiac muscle tissue morphogenesis
GO:0003229 ventricular cardiac muscle tissue development
GO:0003231 cardiac ventricle development
GO:0003249 cell proliferation involved in heart valve morphogenesis
GO:0003250 regulation of cell proliferation involved in heart valve morphogenesis
GO:0003251 positive regulation of cell proliferation involved in heart valve morphogenesis
GO:0003272 endocardial cushion formation
GO:0003279 cardiac septum development
GO:0003281 ventricular septum development
GO:0003300 cardiac muscle hypertrophy
GO:0003348 cardiac endothelial cell differentiation
GO:0003360 brainstem development
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0006479 protein methylation
GO:0006606 protein import into nucleus
GO:0006875 cellular metal ion homeostasis
GO:0006879 cellular iron ion homeostasis
GO:0006913 nucleocytoplasmic transport
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007183 SMAD protein complex assembly
GO:0007184 SMAD protein import into nucleus
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0007369 gastrulation
GO:0007389 pattern specification process
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007492 endoderm development
GO:0007498 mesoderm development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007548 sex differentiation
GO:0008213 protein alkylation
GO:0008406 gonad development
GO:0008544 epidermis development
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0009566 fertilization
GO:0009798 axis specification
GO:0009880 embryonic pattern specification
GO:0009914 hormone transport
GO:0009948 anterior/posterior axis specification
GO:0009952 anterior/posterior pattern specification
GO:0010611 regulation of cardiac muscle hypertrophy
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0010639 negative regulation of organelle organization
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010721 negative regulation of cell development
GO:0010817 regulation of hormone levels
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010927 cellular component assembly involved in morphogenesis
GO:0014033 neural crest cell differentiation
GO:0014706 striated muscle tissue development
GO:0014741 negative regulation of muscle hypertrophy
GO:0014743 regulation of muscle hypertrophy
GO:0014896 muscle hypertrophy
GO:0014897 striated muscle hypertrophy
GO:0016049 cell growth
GO:0016202 regulation of striated muscle tissue development
GO:0016570 histone modification
GO:0016571 histone methylation
GO:0016573 histone acetylation
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0017038 protein import
GO:0018022 peptidyl-lysine methylation
GO:0018205 peptidyl-lysine modification
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0019827 stem cell population maintenance
GO:0022404 molting cycle process
GO:0022405 hair cycle process
GO:0022602 ovulation cycle process
GO:0023061 signal release
GO:0030239 myofibril assembly
GO:0030308 negative regulation of cell growth
GO:0030326 embryonic limb morphogenesis
GO:0030509 BMP signaling pathway
GO:0030510 regulation of BMP signaling pathway
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0031032 actomyosin structure organization
GO:0031056 regulation of histone modification
GO:0031058 positive regulation of histone modification
GO:0031060 regulation of histone methylation
GO:0031062 positive regulation of histone methylation
GO:0032259 methylation
GO:0032274 gonadotropin secretion
GO:0032275 luteinizing hormone secretion
GO:0032276 regulation of gonadotropin secretion
GO:0032278 positive regulation of gonadotropin secretion
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032525 somite rostral/caudal axis specification
GO:0032906 transforming growth factor beta2 production
GO:0032909 regulation of transforming growth factor beta2 production
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0033157 regulation of intracellular protein transport
GO:0033684 regulation of luteinizing hormone secretion
GO:0033686 positive regulation of luteinizing hormone secretion
GO:0034504 protein localization to nucleus
GO:0034968 histone lysine methylation
GO:0035019 somatic stem cell population maintenance
GO:0035051 cardiocyte differentiation
GO:0035065 regulation of histone acetylation
GO:0035066 positive regulation of histone acetylation
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035239 tube morphogenesis
GO:0035262 gonad morphogenesis
GO:0035282 segmentation
GO:0036293 response to decreased oxygen levels
GO:0036302 atrioventricular canal development
GO:0042118 endothelial cell activation
GO:0042303 molting cycle
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042326 negative regulation of phosphorylation
GO:0042633 hair cycle
GO:0042634 regulation of hair cycle
GO:0042692 muscle cell differentiation
GO:0042698 ovulation cycle
GO:0042733 embryonic digit morphogenesis
GO:0043409 negative regulation of MAPK cascade
GO:0043414 macromolecule methylation
GO:0043500 muscle adaptation
GO:0043502 regulation of muscle adaptation
GO:0043543 protein acylation
GO:0043588 skin development
GO:0043966 histone H3 acetylation
GO:0043970 histone H3-K9 acetylation
GO:0044057 regulation of system process
GO:0044060 regulation of endocrine process
GO:0044744 protein targeting to nucleus
GO:0045137 development of primary sexual characteristics
GO:0045165 cell fate commitment
GO:0045446 endothelial cell differentiation
GO:0045682 regulation of epidermis development
GO:0045843 negative regulation of striated muscle tissue development
GO:0045926 negative regulation of growth
GO:0046545 development of primary female sexual characteristics
GO:0046546 development of primary male sexual characteristics
GO:0046660 female sex differentiation
GO:0046661 male sex differentiation
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0046879 hormone secretion
GO:0046880 regulation of follicle-stimulating hormone secretion
GO:0046881 positive regulation of follicle-stimulating hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046884 follicle-stimulating hormone secretion
GO:0046887 positive regulation of hormone secretion
GO:0046916 cellular transition metal ion homeostasis
GO:0048232 male gamete generation
GO:0048511 rhythmic process
GO:0048608 reproductive structure development
GO:0048634 regulation of muscle organ development
GO:0048635 negative regulation of muscle organ development
GO:0048644 muscle organ morphogenesis
GO:0048663 neuron fate commitment
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048732 gland development
GO:0048733 sebaceous gland development
GO:0048736 appendage development
GO:0048738 cardiac muscle tissue development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048762 mesenchymal cell differentiation
GO:0048859 formation of anatomical boundary
GO:0048863 stem cell differentiation
GO:0050886 endocrine process
GO:0051047 positive regulation of secretion
GO:0051098 regulation of binding
GO:0051146 striated muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051148 negative regulation of muscle cell differentiation
GO:0051153 regulation of striated muscle cell differentiation
GO:0051154 negative regulation of striated muscle cell differentiation
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051222 positive regulation of protein transport
GO:0051493 regulation of cytoskeleton organization
GO:0051494 negative regulation of cytoskeleton organization
GO:0051568 histone H3-K4 methylation
GO:0051569 regulation of histone H3-K4 methylation
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0051797 regulation of hair follicle development
GO:0055001 muscle cell development
GO:0055002 striated muscle cell development
GO:0055003 cardiac myofibril assembly
GO:0055006 cardiac cell development
GO:0055007 cardiac muscle cell differentiation
GO:0055008 cardiac muscle tissue morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0055013 cardiac muscle cell development
GO:0055024 regulation of cardiac muscle tissue development
GO:0055026 negative regulation of cardiac muscle tissue development
GO:0055072 iron ion homeostasis
GO:0055076 transition metal ion homeostasis
GO:0060021 palate development
GO:0060065 uterus development
GO:0060173 limb development
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060390 regulation of SMAD protein import into nucleus
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060411 cardiac septum morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060415 muscle tissue morphogenesis
GO:0060485 mesenchyme development
GO:0060537 muscle tissue development
GO:0060562 epithelial tube morphogenesis
GO:0060675 ureteric bud morphogenesis
GO:0060956 endocardial cell differentiation
GO:0060986 endocrine hormone secretion
GO:0060993 kidney morphogenesis
GO:0061040 female gonad morphogenesis
GO:0061053 somite development
GO:0061138 morphogenesis of a branching epithelium
GO:0061323 cell proliferation involved in heart morphogenesis
GO:0061326 renal tubule development
GO:0061333 renal tubule morphogenesis
GO:0061458 reproductive system development
GO:0061564 axon development
GO:0061647 histone H3-K9 modification
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070482 response to oxygen levels
GO:0070741 response to interleukin-6
GO:0071354 cellular response to interleukin-6
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071604 transforming growth factor beta production
GO:0071634 regulation of transforming growth factor beta production
GO:0071772 response to BMP
GO:0071773 cellular response to BMP stimulus
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072028 nephron morphogenesis
GO:0072073 kidney epithelium development
GO:0072074 kidney mesenchyme development
GO:0072075 metanephric mesenchyme development
GO:0072076 nephrogenic mesenchyme development
GO:0072078 nephron tubule morphogenesis
GO:0072080 nephron tubule development
GO:0072088 nephron epithelium morphogenesis
GO:0072131 kidney mesenchyme morphogenesis
GO:0072132 mesenchyme morphogenesis
GO:0072133 metanephric mesenchyme morphogenesis
GO:0072134 nephrogenic mesenchyme morphogenesis
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0072171 mesonephric tubule morphogenesis
GO:0072520 seminiferous tubule development
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090257 regulation of muscle system process
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090316 positive regulation of intracellular protein transport
GO:0097485 neuron projection guidance
GO:0098727 maintenance of cell number
GO:0098773 skin epidermis development
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:1901861 regulation of muscle tissue development
GO:1901862 negative regulation of muscle tissue development
GO:1901983 regulation of protein acetylation
GO:1901985 positive regulation of protein acetylation
GO:1902115 regulation of organelle assembly
GO:1902116 negative regulation of organelle assembly
GO:1902275 regulation of chromatin organization
GO:1902532 negative regulation of intracellular signal transduction
GO:1902593 single-organism nuclear import
GO:1903532 positive regulation of secretion by cell
GO:1903533 regulation of protein targeting
GO:1903829 positive regulation of cellular protein localization
GO:1903844 regulation of cellular response to transforming growth factor beta stimulus
GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus
GO:1904589 regulation of protein import
GO:1904591 positive regulation of protein import
GO:1904951 positive regulation of establishment of protein localization
GO:1905207 regulation of cardiocyte differentiation
GO:1905208 negative regulation of cardiocyte differentiation
GO:1905269 positive regulation of chromatin organization
GO:1905304 regulation of cardiac myofibril assembly
GO:1905305 negative regulation of cardiac myofibril assembly
GO:2000027 regulation of organ morphogenesis
GO:2000136 regulation of cell proliferation involved in heart morphogenesis
GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis
GO:2000615 regulation of histone H3-K9 acetylation
GO:2000617 positive regulation of histone H3-K9 acetylation
GO:2000725 regulation of cardiac muscle cell differentiation
GO:2000726 negative regulation of cardiac muscle cell differentiation
GO:2000756 regulation of peptidyl-lysine acetylation
GO:2000758 positive regulation of peptidyl-lysine acetylation
GO:2000793 cell proliferation involved in heart valve development
GO:2000826 regulation of heart morphogenesis
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001159 core promoter proximal region DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003682 chromatin binding
GO:0005057 receptor signaling protein activity
GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity
GO:0005518 collagen binding
GO:0008134 transcription factor binding
GO:0030616 transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
GO:0046332 SMAD binding
GO:0046982 protein heterodimerization activity
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
Cellular Component GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0005667 transcription factor complex
GO:0032444 activin responsive factor complex
GO:0044454 nuclear chromosome part
GO:0044798 nuclear transcription factor complex
GO:0071141 SMAD protein complex
GO:0090575 RNA polymerase II transcription factor complex
> KEGG and Reactome Pathway
 
KEGG hsa04068 FoxO signaling pathway
hsa04110 Cell cycle
hsa04310 Wnt signaling pathway
hsa04350 TGF-beta signaling pathway
hsa04390 Hippo signaling pathway
hsa04520 Adherens junction
hsa04550 Signaling pathways regulating pluripotency of stem cells
Reactome R-HSA-5688426: Deubiquitination
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-2173795: Downregulation of SMAD2/3
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3304349: Loss of Function of SMAD2/3 in Cancer
R-HSA-3304347: Loss of Function of SMAD4 in Cancer
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-3315487: SMAD2/3 MH2 Domain Mutants in Cancer
R-HSA-2173796: SMAD2/SMAD3
R-HSA-3311021: SMAD4 MH2 Domain Mutants in Cancer
R-HSA-162582: Signal Transduction
R-HSA-1502540: Signaling by Activin
R-HSA-201451: Signaling by BMP
R-HSA-1181150: Signaling by NODAL
R-HSA-170834: Signaling by TGF-beta Receptor Complex
R-HSA-3304351: Signaling by TGF-beta Receptor Complex in Cancer
R-HSA-2173789: TGF-beta receptor signaling activates SMADs
R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3
R-HSA-452723: Transcriptional regulation of pluripotent stem cells
R-HSA-5689880: Ub-specific processing proteases
Summary
SymbolSMAD4
NameSMAD family member 4
Aliases DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ......
Chromosomal Location18q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SMAD4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between SMAD4 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
25577439MelanomaPromote immunity (T cell function)Here we have demonstrated an essential role for Smad4 in promoting T cell function during autoimmunity and anti-tumor immunity.
29632714breast carcinomaPromote immunityIn vitro the 4-1BB-Smad4 conjugate rendered T cells partially resistant to TGFβ inhibition, and treatment of tumor bearing mice with systemically administered 4-1BB-Smad4 conjugate enhanced vaccine- and irradiation-induced antitumor immunity.
Summary
SymbolSMAD4
NameSMAD family member 4
Aliases DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ......
Chromosomal Location18q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SMAD4 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSMAD4
NameSMAD family member 4
Aliases DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ......
Chromosomal Location18q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SMAD4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0250.92
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.010.995
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0370.973
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1220.711
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0630.973
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1960.933
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1040.789
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1750.922
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0030.999
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3840.756
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.9690.601
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0390.472
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SMAD4 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolSMAD4
NameSMAD family member 4
Aliases DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ......
Chromosomal Location18q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SMAD4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSMAD4
NameSMAD family member 4
Aliases DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ......
Chromosomal Location18q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SMAD4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SMAD4.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSMAD4
NameSMAD family member 4
Aliases DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ......
Chromosomal Location18q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SMAD4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSMAD4
NameSMAD family member 4
Aliases DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ......
Chromosomal Location18q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SMAD4 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSMAD4
NameSMAD family member 4
Aliases DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ......
Chromosomal Location18q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SMAD4 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSMAD4
NameSMAD family member 4
Aliases DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ......
Chromosomal Location18q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SMAD4 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.