Summary | |
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Symbol | SMAD4 |
Name | SMAD family member 4 |
Aliases | DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ...... |
Chromosomal Location | 18q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R-SMAD (PubMed:15799969). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236). |
Domain |
PF03165 MH1 domain PF03166 MH2 domain |
Function |
In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
Biological Process |
GO:0000578 embryonic axis specification GO:0001541 ovarian follicle development GO:0001558 regulation of cell growth GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001657 ureteric bud development GO:0001658 branching involved in ureteric bud morphogenesis GO:0001666 response to hypoxia GO:0001701 in utero embryonic development GO:0001702 gastrulation with mouth forming second GO:0001756 somitogenesis GO:0001763 morphogenesis of a branching structure GO:0001822 kidney development GO:0001823 mesonephros development GO:0001837 epithelial to mesenchymal transition GO:0001933 negative regulation of protein phosphorylation GO:0001942 hair follicle development GO:0003002 regionalization GO:0003007 heart morphogenesis GO:0003012 muscle system process GO:0003148 outflow tract septum morphogenesis GO:0003151 outflow tract morphogenesis GO:0003157 endocardium development GO:0003158 endothelium development GO:0003170 heart valve development GO:0003171 atrioventricular valve development GO:0003179 heart valve morphogenesis GO:0003181 atrioventricular valve morphogenesis GO:0003188 heart valve formation GO:0003190 atrioventricular valve formation GO:0003197 endocardial cushion development GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003203 endocardial cushion morphogenesis GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003208 cardiac ventricle morphogenesis GO:0003214 cardiac left ventricle morphogenesis GO:0003220 left ventricular cardiac muscle tissue morphogenesis GO:0003229 ventricular cardiac muscle tissue development GO:0003231 cardiac ventricle development GO:0003249 cell proliferation involved in heart valve morphogenesis GO:0003250 regulation of cell proliferation involved in heart valve morphogenesis GO:0003251 positive regulation of cell proliferation involved in heart valve morphogenesis GO:0003272 endocardial cushion formation GO:0003279 cardiac septum development GO:0003281 ventricular septum development GO:0003300 cardiac muscle hypertrophy GO:0003348 cardiac endothelial cell differentiation GO:0003360 brainstem development GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006479 protein methylation GO:0006606 protein import into nucleus GO:0006875 cellular metal ion homeostasis GO:0006879 cellular iron ion homeostasis GO:0006913 nucleocytoplasmic transport GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007183 SMAD protein complex assembly GO:0007184 SMAD protein import into nucleus GO:0007283 spermatogenesis GO:0007338 single fertilization GO:0007369 gastrulation GO:0007389 pattern specification process GO:0007409 axonogenesis GO:0007411 axon guidance GO:0007492 endoderm development GO:0007498 mesoderm development GO:0007507 heart development GO:0007517 muscle organ development GO:0007548 sex differentiation GO:0008213 protein alkylation GO:0008406 gonad development GO:0008544 epidermis development GO:0008584 male gonad development GO:0008585 female gonad development GO:0009566 fertilization GO:0009798 axis specification GO:0009880 embryonic pattern specification GO:0009914 hormone transport GO:0009948 anterior/posterior axis specification GO:0009952 anterior/posterior pattern specification GO:0010611 regulation of cardiac muscle hypertrophy GO:0010614 negative regulation of cardiac muscle hypertrophy GO:0010639 negative regulation of organelle organization GO:0010717 regulation of epithelial to mesenchymal transition GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0010721 negative regulation of cell development GO:0010817 regulation of hormone levels GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010927 cellular component assembly involved in morphogenesis GO:0014033 neural crest cell differentiation GO:0014706 striated muscle tissue development GO:0014741 negative regulation of muscle hypertrophy GO:0014743 regulation of muscle hypertrophy GO:0014896 muscle hypertrophy GO:0014897 striated muscle hypertrophy GO:0016049 cell growth GO:0016202 regulation of striated muscle tissue development GO:0016570 histone modification GO:0016571 histone methylation GO:0016573 histone acetylation GO:0017015 regulation of transforming growth factor beta receptor signaling pathway GO:0017038 protein import GO:0018022 peptidyl-lysine methylation GO:0018205 peptidyl-lysine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0019827 stem cell population maintenance GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0022602 ovulation cycle process GO:0023061 signal release GO:0030239 myofibril assembly GO:0030308 negative regulation of cell growth GO:0030326 embryonic limb morphogenesis GO:0030509 BMP signaling pathway GO:0030510 regulation of BMP signaling pathway GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway GO:0030513 positive regulation of BMP signaling pathway GO:0031032 actomyosin structure organization GO:0031056 regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031060 regulation of histone methylation GO:0031062 positive regulation of histone methylation GO:0032259 methylation GO:0032274 gonadotropin secretion GO:0032275 luteinizing hormone secretion GO:0032276 regulation of gonadotropin secretion GO:0032278 positive regulation of gonadotropin secretion GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032525 somite rostral/caudal axis specification GO:0032906 transforming growth factor beta2 production GO:0032909 regulation of transforming growth factor beta2 production GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0033157 regulation of intracellular protein transport GO:0033684 regulation of luteinizing hormone secretion GO:0033686 positive regulation of luteinizing hormone secretion GO:0034504 protein localization to nucleus GO:0034968 histone lysine methylation GO:0035019 somatic stem cell population maintenance GO:0035051 cardiocyte differentiation GO:0035065 regulation of histone acetylation GO:0035066 positive regulation of histone acetylation GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035239 tube morphogenesis GO:0035262 gonad morphogenesis GO:0035282 segmentation GO:0036293 response to decreased oxygen levels GO:0036302 atrioventricular canal development GO:0042118 endothelial cell activation GO:0042303 molting cycle GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042326 negative regulation of phosphorylation GO:0042633 hair cycle GO:0042634 regulation of hair cycle GO:0042692 muscle cell differentiation GO:0042698 ovulation cycle GO:0042733 embryonic digit morphogenesis GO:0043409 negative regulation of MAPK cascade GO:0043414 macromolecule methylation GO:0043500 muscle adaptation GO:0043502 regulation of muscle adaptation GO:0043543 protein acylation GO:0043588 skin development GO:0043966 histone H3 acetylation GO:0043970 histone H3-K9 acetylation GO:0044057 regulation of system process GO:0044060 regulation of endocrine process GO:0044744 protein targeting to nucleus GO:0045137 development of primary sexual characteristics GO:0045165 cell fate commitment GO:0045446 endothelial cell differentiation GO:0045682 regulation of epidermis development GO:0045843 negative regulation of striated muscle tissue development GO:0045926 negative regulation of growth GO:0046545 development of primary female sexual characteristics GO:0046546 development of primary male sexual characteristics GO:0046660 female sex differentiation GO:0046661 male sex differentiation GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0046879 hormone secretion GO:0046880 regulation of follicle-stimulating hormone secretion GO:0046881 positive regulation of follicle-stimulating hormone secretion GO:0046883 regulation of hormone secretion GO:0046884 follicle-stimulating hormone secretion GO:0046887 positive regulation of hormone secretion GO:0046916 cellular transition metal ion homeostasis GO:0048232 male gamete generation GO:0048511 rhythmic process GO:0048608 reproductive structure development GO:0048634 regulation of muscle organ development GO:0048635 negative regulation of muscle organ development GO:0048644 muscle organ morphogenesis GO:0048663 neuron fate commitment GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048732 gland development GO:0048733 sebaceous gland development GO:0048736 appendage development GO:0048738 cardiac muscle tissue development GO:0048754 branching morphogenesis of an epithelial tube GO:0048762 mesenchymal cell differentiation GO:0048859 formation of anatomical boundary GO:0048863 stem cell differentiation GO:0050886 endocrine process GO:0051047 positive regulation of secretion GO:0051098 regulation of binding GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051148 negative regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051154 negative regulation of striated muscle cell differentiation GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051222 positive regulation of protein transport GO:0051493 regulation of cytoskeleton organization GO:0051494 negative regulation of cytoskeleton organization GO:0051568 histone H3-K4 methylation GO:0051569 regulation of histone H3-K4 methylation GO:0051571 positive regulation of histone H3-K4 methylation GO:0051797 regulation of hair follicle development GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0055003 cardiac myofibril assembly GO:0055006 cardiac cell development GO:0055007 cardiac muscle cell differentiation GO:0055008 cardiac muscle tissue morphogenesis GO:0055010 ventricular cardiac muscle tissue morphogenesis GO:0055013 cardiac muscle cell development GO:0055024 regulation of cardiac muscle tissue development GO:0055026 negative regulation of cardiac muscle tissue development GO:0055072 iron ion homeostasis GO:0055076 transition metal ion homeostasis GO:0060021 palate development GO:0060065 uterus development GO:0060173 limb development GO:0060317 cardiac epithelial to mesenchymal transition GO:0060389 pathway-restricted SMAD protein phosphorylation GO:0060390 regulation of SMAD protein import into nucleus GO:0060391 positive regulation of SMAD protein import into nucleus GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation GO:0060395 SMAD protein signal transduction GO:0060411 cardiac septum morphogenesis GO:0060412 ventricular septum morphogenesis GO:0060415 muscle tissue morphogenesis GO:0060485 mesenchyme development GO:0060537 muscle tissue development GO:0060562 epithelial tube morphogenesis GO:0060675 ureteric bud morphogenesis GO:0060956 endocardial cell differentiation GO:0060986 endocrine hormone secretion GO:0060993 kidney morphogenesis GO:0061040 female gonad morphogenesis GO:0061053 somite development GO:0061138 morphogenesis of a branching epithelium GO:0061323 cell proliferation involved in heart morphogenesis GO:0061326 renal tubule development GO:0061333 renal tubule morphogenesis GO:0061458 reproductive system development GO:0061564 axon development GO:0061647 histone H3-K9 modification GO:0070102 interleukin-6-mediated signaling pathway GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:0070482 response to oxygen levels GO:0070741 response to interleukin-6 GO:0071354 cellular response to interleukin-6 GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071604 transforming growth factor beta production GO:0071634 regulation of transforming growth factor beta production GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0072001 renal system development GO:0072006 nephron development GO:0072009 nephron epithelium development GO:0072028 nephron morphogenesis GO:0072073 kidney epithelium development GO:0072074 kidney mesenchyme development GO:0072075 metanephric mesenchyme development GO:0072076 nephrogenic mesenchyme development GO:0072078 nephron tubule morphogenesis GO:0072080 nephron tubule development GO:0072088 nephron epithelium morphogenesis GO:0072131 kidney mesenchyme morphogenesis GO:0072132 mesenchyme morphogenesis GO:0072133 metanephric mesenchyme morphogenesis GO:0072134 nephrogenic mesenchyme morphogenesis GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:0072171 mesonephric tubule morphogenesis GO:0072520 seminiferous tubule development GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090257 regulation of muscle system process GO:0090287 regulation of cellular response to growth factor stimulus GO:0090316 positive regulation of intracellular protein transport GO:0097485 neuron projection guidance GO:0098727 maintenance of cell number GO:0098773 skin epidermis development GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901861 regulation of muscle tissue development GO:1901862 negative regulation of muscle tissue development GO:1901983 regulation of protein acetylation GO:1901985 positive regulation of protein acetylation GO:1902115 regulation of organelle assembly GO:1902116 negative regulation of organelle assembly GO:1902275 regulation of chromatin organization GO:1902532 negative regulation of intracellular signal transduction GO:1902593 single-organism nuclear import GO:1903532 positive regulation of secretion by cell GO:1903533 regulation of protein targeting GO:1903829 positive regulation of cellular protein localization GO:1903844 regulation of cellular response to transforming growth factor beta stimulus GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904951 positive regulation of establishment of protein localization GO:1905207 regulation of cardiocyte differentiation GO:1905208 negative regulation of cardiocyte differentiation GO:1905269 positive regulation of chromatin organization GO:1905304 regulation of cardiac myofibril assembly GO:1905305 negative regulation of cardiac myofibril assembly GO:2000027 regulation of organ morphogenesis GO:2000136 regulation of cell proliferation involved in heart morphogenesis GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis GO:2000615 regulation of histone H3-K9 acetylation GO:2000617 positive regulation of histone H3-K9 acetylation GO:2000725 regulation of cardiac muscle cell differentiation GO:2000726 negative regulation of cardiac muscle cell differentiation GO:2000756 regulation of peptidyl-lysine acetylation GO:2000758 positive regulation of peptidyl-lysine acetylation GO:2000793 cell proliferation involved in heart valve development GO:2000826 regulation of heart morphogenesis |
Molecular Function |
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001085 RNA polymerase II transcription factor binding GO:0001159 core promoter proximal region DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0005057 receptor signaling protein activity GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity GO:0005518 collagen binding GO:0008134 transcription factor binding GO:0030616 transforming growth factor beta receptor, common-partner cytoplasmic mediator activity GO:0046332 SMAD binding GO:0046982 protein heterodimerization activity GO:0070411 I-SMAD binding GO:0070412 R-SMAD binding |
Cellular Component |
GO:0000785 chromatin GO:0000790 nuclear chromatin GO:0005667 transcription factor complex GO:0032444 activin responsive factor complex GO:0044454 nuclear chromosome part GO:0044798 nuclear transcription factor complex GO:0071141 SMAD protein complex GO:0090575 RNA polymerase II transcription factor complex |
KEGG |
hsa04068 FoxO signaling pathway hsa04110 Cell cycle hsa04310 Wnt signaling pathway hsa04350 TGF-beta signaling pathway hsa04390 Hippo signaling pathway hsa04520 Adherens junction hsa04550 Signaling pathways regulating pluripotency of stem cells |
Reactome |
R-HSA-5688426: Deubiquitination R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-2173795: Downregulation of SMAD2/3 R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-3304349: Loss of Function of SMAD2/3 in Cancer R-HSA-3304347: Loss of Function of SMAD4 in Cancer R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-3315487: SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-2173796: SMAD2/SMAD3 R-HSA-3311021: SMAD4 MH2 Domain Mutants in Cancer R-HSA-162582: Signal Transduction R-HSA-1502540: Signaling by Activin R-HSA-201451: Signaling by BMP R-HSA-1181150: Signaling by NODAL R-HSA-170834: Signaling by TGF-beta Receptor Complex R-HSA-3304351: Signaling by TGF-beta Receptor Complex in Cancer R-HSA-2173789: TGF-beta receptor signaling activates SMADs R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3 R-HSA-452723: Transcriptional regulation of pluripotent stem cells R-HSA-5689880: Ub-specific processing proteases |
Summary | |
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Symbol | SMAD4 |
Name | SMAD family member 4 |
Aliases | DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ...... |
Chromosomal Location | 18q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SMAD4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between SMAD4 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | SMAD4 |
Name | SMAD family member 4 |
Aliases | DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ...... |
Chromosomal Location | 18q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SMAD4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SMAD4 |
Name | SMAD family member 4 |
Aliases | DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ...... |
Chromosomal Location | 18q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SMAD4 in various data sets.
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Points in the above scatter plot represent the mutation difference of SMAD4 in various data sets.
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Summary | |
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Symbol | SMAD4 |
Name | SMAD family member 4 |
Aliases | DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ...... |
Chromosomal Location | 18q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SMAD4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | SMAD4 |
Name | SMAD family member 4 |
Aliases | DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ...... |
Chromosomal Location | 18q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SMAD4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SMAD4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | SMAD4 |
Name | SMAD family member 4 |
Aliases | DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ...... |
Chromosomal Location | 18q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SMAD4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | SMAD4 |
Name | SMAD family member 4 |
Aliases | DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ...... |
Chromosomal Location | 18q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SMAD4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SMAD4 |
Name | SMAD family member 4 |
Aliases | DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ...... |
Chromosomal Location | 18q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SMAD4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SMAD4 |
Name | SMAD family member 4 |
Aliases | DPC4; MADH4; MAD, mothers against decapentaplegic homolog 4 (Drosophila); SMAD, mothers against DPP homolog ...... |
Chromosomal Location | 18q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SMAD4 collected from DrugBank database. |
There is no record. |