Browse SNRPE

Summary
SymbolSNRPE
Namesmall nuclear ribonucleoprotein polypeptide E
Aliases Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E
Chromosomal Location1q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytosol. Nucleus. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Domain PF01423 LSM domain
Function

Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.

> Gene Ontology
 
Biological Process GO:0000245 spliceosomal complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000387 spliceosomal snRNP assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006353 DNA-templated transcription, termination
GO:0006369 termination of RNA polymerase II transcription
GO:0006397 mRNA processing
GO:0006913 nucleocytoplasmic transport
GO:0008334 histone mRNA metabolic process
GO:0008380 RNA splicing
GO:0022613 ribonucleoprotein complex biogenesis
GO:0022618 ribonucleoprotein complex assembly
GO:0042303 molting cycle
GO:0042633 hair cycle
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0071826 ribonucleoprotein complex subunit organization
Molecular Function -
Cellular Component GO:0005681 spliceosomal complex
GO:0005682 U5 snRNP
GO:0005683 U7 snRNP
GO:0005685 U1 snRNP
GO:0005686 U2 snRNP
GO:0005687 U4 snRNP
GO:0005689 U12-type spliceosomal complex
GO:0005697 telomerase holoenzyme complex
GO:0030532 small nuclear ribonucleoprotein complex
GO:0034708 methyltransferase complex
GO:0034709 methylosome
GO:0034715 pICln-Sm protein complex
GO:0034719 SMN-Sm protein complex
GO:0046540 U4/U6 x U5 tri-snRNP complex
GO:0071011 precatalytic spliceosome
GO:0071013 catalytic step 2 spliceosome
GO:0097525 spliceosomal snRNP complex
GO:0097526 spliceosomal tri-snRNP complex
> KEGG and Reactome Pathway
 
KEGG hsa03040 Spliceosome
Reactome R-HSA-109688: Cleavage of Growing Transcript in the Termination Region
R-HSA-74160: Gene Expression
R-HSA-194441: Metabolism of non-coding RNA
R-HSA-112297: Post-Elongation Processing of Intronless pre-mRNA
R-HSA-76044: Post-Elongation Processing of the Transcript
R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA
R-HSA-75067: Processing of Capped Intronless Pre-mRNA
R-HSA-73857: RNA Polymerase II Transcription
R-HSA-73856: RNA Polymerase II Transcription Termination
R-HSA-77588: SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
R-HSA-111367: SLBP independent Processing of Histone Pre-mRNAs
R-HSA-72172: mRNA Splicing
R-HSA-72163: mRNA Splicing - Major Pathway
R-HSA-72165: mRNA Splicing - Minor Pathway
R-HSA-191859: snRNP Assembly
Summary
SymbolSNRPE
Namesmall nuclear ribonucleoprotein polypeptide E
Aliases Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E
Chromosomal Location1q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SNRPE and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSNRPE
Namesmall nuclear ribonucleoprotein polypeptide E
Aliases Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E
Chromosomal Location1q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SNRPE in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.56 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSNRPE
Namesmall nuclear ribonucleoprotein polypeptide E
Aliases Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E
Chromosomal Location1q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SNRPE in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.090.765
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1660.955
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0330.988
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1620.66
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3360.766
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0540.967
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1790.686
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5620.761
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2650.896
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0170.994
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0970.978
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1060.34
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolSNRPE
Namesmall nuclear ribonucleoprotein polypeptide E
Aliases Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E
Chromosomal Location1q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SNRPE. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSNRPE
Namesmall nuclear ribonucleoprotein polypeptide E
Aliases Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E
Chromosomal Location1q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SNRPE. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SNRPE.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSNRPE
Namesmall nuclear ribonucleoprotein polypeptide E
Aliases Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E
Chromosomal Location1q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SNRPE. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSNRPE
Namesmall nuclear ribonucleoprotein polypeptide E
Aliases Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E
Chromosomal Location1q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SNRPE expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSNRPE
Namesmall nuclear ribonucleoprotein polypeptide E
Aliases Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E
Chromosomal Location1q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SNRPE and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSNRPE
Namesmall nuclear ribonucleoprotein polypeptide E
Aliases Sm-E; B-raf; HYPT11; SME; sm protein E; snRNP-E; Small nuclear ribonucleoprotein E
Chromosomal Location1q32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SNRPE collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.