Browse SOCS2

Summary
SymbolSOCS2
Namesuppressor of cytokine signaling 2
Aliases STATI2; SSI2; SOCS-2; SSI-2; CIS2; Cish2; STAT-induced STAT inhibitor-2; CIS-2; STAT induced STAT inhibitor- ......
Chromosomal Location12q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF00017 SH2 domain
PF07525 SOCS box
Function

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

> Gene Ontology
 
Biological Process GO:0001558 regulation of cell growth
GO:0001933 negative regulation of protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0007259 JAK-STAT cascade
GO:0008286 insulin receptor signaling pathway
GO:0016049 cell growth
GO:0032355 response to estradiol
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033673 negative regulation of kinase activity
GO:0042326 negative regulation of phosphorylation
GO:0043434 response to peptide hormone
GO:0046425 regulation of JAK-STAT cascade
GO:0046426 negative regulation of JAK-STAT cascade
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0051348 negative regulation of transferase activity
GO:0060396 growth hormone receptor signaling pathway
GO:0060416 response to growth hormone
GO:0071375 cellular response to peptide hormone stimulus
GO:0071378 cellular response to growth hormone stimulus
GO:0071417 cellular response to organonitrogen compound
GO:0097696 STAT cascade
GO:1900076 regulation of cellular response to insulin stimulus
GO:1900077 negative regulation of cellular response to insulin stimulus
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1902532 negative regulation of intracellular signal transduction
GO:1904892 regulation of STAT cascade
GO:1904893 negative regulation of STAT cascade
Molecular Function GO:0004857 enzyme inhibitor activity
GO:0004860 protein kinase inhibitor activity
GO:0005070 SH3/SH2 adaptor activity
GO:0005126 cytokine receptor binding
GO:0005131 growth hormone receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0008269 JAK pathway signal transduction adaptor activity
GO:0019207 kinase regulator activity
GO:0019210 kinase inhibitor activity
GO:0019887 protein kinase regulator activity
GO:0030674 protein binding, bridging
GO:0035591 signaling adaptor activity
GO:0051427 hormone receptor binding
GO:0060090 binding, bridging
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04630 Jak-STAT signaling pathway
hsa04910 Insulin signaling pathway
hsa04917 Prolactin signaling pathway
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-982772: Growth hormone receptor signaling
R-HSA-168256: Immune System
Summary
SymbolSOCS2
Namesuppressor of cytokine signaling 2
Aliases STATI2; SSI2; SOCS-2; SSI-2; CIS2; Cish2; STAT-induced STAT inhibitor-2; CIS-2; STAT induced STAT inhibitor- ......
Chromosomal Location12q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SOCS2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between SOCS2 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
28666115MelanomaInhibit immunitySuppressor-of-cytokine-2 (SOCS2) protein, a conserved program transcript, is expressed by mononuclear phagocytes infiltrating primary melanoma and is induced by IFNγ. SOCS2 limits adaptive anti-tumoral immunity and DC-based priming of T cells in vivo, indicating a critical regulatory role.
Summary
SymbolSOCS2
Namesuppressor of cytokine signaling 2
Aliases STATI2; SSI2; SOCS-2; SSI-2; CIS2; Cish2; STAT-induced STAT inhibitor-2; CIS-2; STAT induced STAT inhibitor- ......
Chromosomal Location12q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SOCS2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSOCS2
Namesuppressor of cytokine signaling 2
Aliases STATI2; SSI2; SOCS-2; SSI-2; CIS2; Cish2; STAT-induced STAT inhibitor-2; CIS-2; STAT induced STAT inhibitor- ......
Chromosomal Location12q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SOCS2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2340.48
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6790.572
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0950.911
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4190.384
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4530.787
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3780.852
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2330.504
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.6190.607
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3130.791
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.3710.175
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.8770.205
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2870.0729
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SOCS2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSOCS2
Namesuppressor of cytokine signaling 2
Aliases STATI2; SSI2; SOCS-2; SSI-2; CIS2; Cish2; STAT-induced STAT inhibitor-2; CIS-2; STAT induced STAT inhibitor- ......
Chromosomal Location12q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SOCS2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSOCS2
Namesuppressor of cytokine signaling 2
Aliases STATI2; SSI2; SOCS-2; SSI-2; CIS2; Cish2; STAT-induced STAT inhibitor-2; CIS-2; STAT induced STAT inhibitor- ......
Chromosomal Location12q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SOCS2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SOCS2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSOCS2
Namesuppressor of cytokine signaling 2
Aliases STATI2; SSI2; SOCS-2; SSI-2; CIS2; Cish2; STAT-induced STAT inhibitor-2; CIS-2; STAT induced STAT inhibitor- ......
Chromosomal Location12q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SOCS2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSOCS2
Namesuppressor of cytokine signaling 2
Aliases STATI2; SSI2; SOCS-2; SSI-2; CIS2; Cish2; STAT-induced STAT inhibitor-2; CIS-2; STAT induced STAT inhibitor- ......
Chromosomal Location12q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SOCS2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSOCS2
Namesuppressor of cytokine signaling 2
Aliases STATI2; SSI2; SOCS-2; SSI-2; CIS2; Cish2; STAT-induced STAT inhibitor-2; CIS-2; STAT induced STAT inhibitor- ......
Chromosomal Location12q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SOCS2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSOCS2
Namesuppressor of cytokine signaling 2
Aliases STATI2; SSI2; SOCS-2; SSI-2; CIS2; Cish2; STAT-induced STAT inhibitor-2; CIS-2; STAT induced STAT inhibitor- ......
Chromosomal Location12q
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SOCS2 collected from DrugBank database.
> Drugs from DrugBank database
 

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