TISIDB

Summary
Symbol	SOX10
Name	SRY (sex determining region Y)-box 10
Aliases	DOM; WS4; WS2E; dominant megacolon, mouse, human homolog of; PCWH; WS4C; SRY-related HMG-box gene 10; Transc ......
Chromosomal Location	22q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm Nucleus Mitochondrion outer membrane Peripheral membrane protein Cytoplasmic side
Domain	PF00505 HMG (high mobility group) box PF12444 Sox developmental protein N terminal
Function	Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087).

> Gene Ontology [ TOP ]
Biological Process	GO:0001667 ameboidal-type cell migration GO:0001701 in utero embryonic development GO:0001755 neural crest cell migration GO:0001763 morphogenesis of a branching structure GO:0002052 positive regulation of neuroblast proliferation GO:0007405 neuroblast proliferation GO:0007422 peripheral nervous system development GO:0010001 glial cell differentiation GO:0010720 positive regulation of cell development GO:0014013 regulation of gliogenesis GO:0014015 positive regulation of gliogenesis GO:0014031 mesenchymal cell development GO:0014032 neural crest cell development GO:0014033 neural crest cell differentiation GO:0016055 Wnt signaling pathway GO:0021700 developmental maturation GO:0030111 regulation of Wnt signaling pathway GO:0030178 negative regulation of Wnt signaling pathway GO:0030318 melanocyte differentiation GO:0032808 lacrimal gland development GO:0035239 tube morphogenesis GO:0035272 exocrine system development GO:0042063 gliogenesis GO:0043473 pigmentation GO:0048066 developmental pigmentation GO:0048469 cell maturation GO:0048483 autonomic nervous system development GO:0048484 enteric nervous system development GO:0048546 digestive tract morphogenesis GO:0048565 digestive tract development GO:0048709 oligodendrocyte differentiation GO:0048732 gland development GO:0048762 mesenchymal cell differentiation GO:0048863 stem cell differentiation GO:0048864 stem cell development GO:0050769 positive regulation of neurogenesis GO:0050931 pigment cell differentiation GO:0051962 positive regulation of nervous system development GO:0055123 digestive system development GO:0060070 canonical Wnt signaling pathway GO:0060485 mesenchyme development GO:0060828 regulation of canonical Wnt signaling pathway GO:0061138 morphogenesis of a branching epithelium GO:0061351 neural precursor cell proliferation GO:0072089 stem cell proliferation GO:0072091 regulation of stem cell proliferation GO:0090090 negative regulation of canonical Wnt signaling pathway GO:0198738 cell-cell signaling by wnt GO:1902692 regulation of neuroblast proliferation GO:2000177 regulation of neural precursor cell proliferation GO:2000179 positive regulation of neural precursor cell proliferation GO:2000648 positive regulation of stem cell proliferation
Molecular Function	GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001158 enhancer sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0003682 chromatin binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003713 transcription coactivator activity GO:0008134 transcription factor binding GO:0035326 enhancer binding GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding
Cellular Component	GO:0005741 mitochondrial outer membrane GO:0019867 outer membrane GO:0019898 extrinsic component of membrane GO:0031312 extrinsic component of organelle membrane GO:0031315 extrinsic component of mitochondrial outer membrane GO:0031968 organelle outer membrane GO:0044455 mitochondrial membrane part

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	SOX10
Name	SRY (sex determining region Y)-box 10
Aliases	DOM; WS4; WS2E; dominant megacolon, mouse, human homolog of; PCWH; WS4C; SRY-related HMG-box gene 10; Transc ......
Chromosomal Location	22q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between SOX10 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between SOX10 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
28783722	Melanoma	Promote immunity (T cell function); essential for immunotherapy	In addition, many genes without an established connection to the EFT were ranked amongst the top 20 enriched genes in this genome-scale analysis, such as SOX10, CD58, MLANA, PSMB5, RPL23 and APLNR. Fifteen genes showed significant resistance to T-cell-mediated cytolysis with at least 1 sgRNA in these cells.

Summary
Symbol	SOX10
Name	SRY (sex determining region Y)-box 10
Aliases	DOM; WS4; WS2E; dominant megacolon, mouse, human homolog of; PCWH; WS4C; SRY-related HMG-box gene 10; Transc ......
Chromosomal Location	22q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of SOX10 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	Second most enriched score: 1.67	Sensitive to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	SOX10
Name	SRY (sex determining region Y)-box 10
Aliases	DOM; WS4; WS2E; dominant megacolon, mouse, human homolog of; PCWH; WS4C; SRY-related HMG-box gene 10; Transc ......
Chromosomal Location	22q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of SOX10 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.889	0.315
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	1.248	0.707
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.624	0.806
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.415	0.342
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.284	0.842
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.592	0.694
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.171	0.827
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.214	0.921
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.658	0.777
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0	1
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0	1
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.175	0.575

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of SOX10 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	1.4	6	0.177
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	1.7	5.7	0.231
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	SOX10
Name	SRY (sex determining region Y)-box 10
Aliases	DOM; WS4; WS2E; dominant megacolon, mouse, human homolog of; PCWH; WS4C; SRY-related HMG-box gene 10; Transc ......
Chromosomal Location	22q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SOX10. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	SOX10
Name	SRY (sex determining region Y)-box 10
Aliases	DOM; WS4; WS2E; dominant megacolon, mouse, human homolog of; PCWH; WS4C; SRY-related HMG-box gene 10; Transc ......
Chromosomal Location	22q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SOX10. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SOX10. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	SOX10
Name	SRY (sex determining region Y)-box 10
Aliases	DOM; WS4; WS2E; dominant megacolon, mouse, human homolog of; PCWH; WS4C; SRY-related HMG-box gene 10; Transc ......
Chromosomal Location	22q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SOX10. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	SOX10
Name	SRY (sex determining region Y)-box 10
Aliases	DOM; WS4; WS2E; dominant megacolon, mouse, human homolog of; PCWH; WS4C; SRY-related HMG-box gene 10; Transc ......
Chromosomal Location	22q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of SOX10 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	SOX10
Name	SRY (sex determining region Y)-box 10
Aliases	DOM; WS4; WS2E; dominant megacolon, mouse, human homolog of; PCWH; WS4C; SRY-related HMG-box gene 10; Transc ......
Chromosomal Location	22q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between SOX10 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	SOX10
Name	SRY (sex determining region Y)-box 10
Aliases	DOM; WS4; WS2E; dominant megacolon, mouse, human homolog of; PCWH; WS4C; SRY-related HMG-box gene 10; Transc ......
Chromosomal Location	22q13.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting SOX10 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse SOX10