Browse SOX11

Summary
SymbolSOX11
NameSRY (sex determining region Y)-box 11
Aliases SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11
Chromosomal Location2p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00505 HMG (high mobility group) box
Function

Transcriptional factor involved in the embryonic neurogenesis. May also have a role in tissue modeling during development.

> Gene Ontology
 
Biological Process GO:0000075 cell cycle checkpoint
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0001654 eye development
GO:0001655 urogenital system development
GO:0001822 kidney development
GO:0001838 embryonic epithelial tube formation
GO:0001841 neural tube formation
GO:0002011 morphogenesis of an epithelial sheet
GO:0002065 columnar/cuboidal epithelial cell differentiation
GO:0002072 optic cup morphogenesis involved in camera-type eye development
GO:0002088 lens development in camera-type eye
GO:0002089 lens morphogenesis in camera-type eye
GO:0002683 negative regulation of immune system process
GO:0002694 regulation of leukocyte activation
GO:0002695 negative regulation of leukocyte activation
GO:0003007 heart morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003205 cardiac chamber development
GO:0003206 cardiac chamber morphogenesis
GO:0003207 cardiac chamber formation
GO:0003208 cardiac ventricle morphogenesis
GO:0003211 cardiac ventricle formation
GO:0003231 cardiac ventricle development
GO:0003279 cardiac septum development
GO:0003281 ventricular septum development
GO:0003357 noradrenergic neuron differentiation
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007423 sensory organ development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0009914 hormone transport
GO:0010001 glial cell differentiation
GO:0010720 positive regulation of cell development
GO:0010721 negative regulation of cell development
GO:0010817 regulation of hormone levels
GO:0010948 negative regulation of cell cycle process
GO:0014003 oligodendrocyte development
GO:0014009 glial cell proliferation
GO:0014013 regulation of gliogenesis
GO:0014014 negative regulation of gliogenesis
GO:0014031 mesenchymal cell development
GO:0014032 neural crest cell development
GO:0014033 neural crest cell differentiation
GO:0014706 striated muscle tissue development
GO:0016331 morphogenesis of embryonic epithelium
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0021510 spinal cord development
GO:0021782 glial cell development
GO:0021915 neural tube development
GO:0023061 signal release
GO:0030278 regulation of ossification
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030509 BMP signaling pathway
GO:0030510 regulation of BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0031076 embryonic camera-type eye development
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032945 negative regulation of mononuclear cell proliferation
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035329 hippo signaling
GO:0035330 regulation of hippo signaling
GO:0035332 positive regulation of hippo signaling
GO:0035914 skeletal muscle cell differentiation
GO:0042063 gliogenesis
GO:0043010 camera-type eye development
GO:0043392 negative regulation of DNA binding
GO:0044770 cell cycle phase transition
GO:0045666 positive regulation of neuron differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045786 negative regulation of cell cycle
GO:0046651 lymphocyte proliferation
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046887 positive regulation of hormone secretion
GO:0048048 embryonic eye morphogenesis
GO:0048483 autonomic nervous system development
GO:0048485 sympathetic nervous system development
GO:0048546 digestive tract morphogenesis
GO:0048557 embryonic digestive tract morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048565 digestive tract development
GO:0048566 embryonic digestive tract development
GO:0048568 embryonic organ development
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048709 oligodendrocyte differentiation
GO:0048736 appendage development
GO:0048762 mesenchymal cell differentiation
GO:0048863 stem cell differentiation
GO:0048864 stem cell development
GO:0050670 regulation of lymphocyte proliferation
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050768 negative regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0050865 regulation of cell activation
GO:0050866 negative regulation of cell activation
GO:0051047 positive regulation of secretion
GO:0051098 regulation of binding
GO:0051100 negative regulation of binding
GO:0051101 regulation of DNA binding
GO:0051249 regulation of lymphocyte activation
GO:0051250 negative regulation of lymphocyte activation
GO:0051961 negative regulation of nervous system development
GO:0051962 positive regulation of nervous system development
GO:0055123 digestive system development
GO:0060021 palate development
GO:0060022 hard palate development
GO:0060023 soft palate development
GO:0060173 limb development
GO:0060174 limb bud formation
GO:0060251 regulation of glial cell proliferation
GO:0060253 negative regulation of glial cell proliferation
GO:0060411 cardiac septum morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060425 lung morphogenesis
GO:0060485 mesenchyme development
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0060541 respiratory system development
GO:0060562 epithelial tube morphogenesis
GO:0060563 neuroepithelial cell differentiation
GO:0060900 embryonic camera-type eye formation
GO:0061029 eyelid development in camera-type eye
GO:0061053 somite development
GO:0061303 cornea development in camera-type eye
GO:0061386 closure of optic fissure
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070664 negative regulation of leukocyte proliferation
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071772 response to BMP
GO:0071773 cellular response to BMP stimulus
GO:0072001 renal system development
GO:0072089 stem cell proliferation
GO:0072091 regulation of stem cell proliferation
GO:0072175 epithelial tube formation
GO:0072395 signal transduction involved in cell cycle checkpoint
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090596 sensory organ morphogenesis
GO:0097166 lens epithelial cell proliferation
GO:1901987 regulation of cell cycle phase transition
GO:1901988 negative regulation of cell cycle phase transition
GO:1903532 positive regulation of secretion by cell
GO:1903844 regulation of cellular response to transforming growth factor beta stimulus
GO:2000648 positive regulation of stem cell proliferation
GO:2000677 regulation of transcription regulatory region DNA binding
GO:2000678 negative regulation of transcription regulatory region DNA binding
GO:2001109 regulation of lens epithelial cell proliferation
GO:2001111 positive regulation of lens epithelial cell proliferation
Molecular Function GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0001158 enhancer sequence-specific DNA binding
GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003713 transcription coactivator activity
GO:0008135 translation factor activity, RNA binding
GO:0035326 enhancer binding
GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolSOX11
NameSRY (sex determining region Y)-box 11
Aliases SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11
Chromosomal Location2p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SOX11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSOX11
NameSRY (sex determining region Y)-box 11
Aliases SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11
Chromosomal Location2p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SOX11 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.48; FDR: 0.04170 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSOX11
NameSRY (sex determining region Y)-box 11
Aliases SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11
Chromosomal Location2p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SOX11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3420.36
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.5610.412
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1960.699
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0940.902
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.4450.791
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3530.857
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.020.981
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.540.207
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11121.8060.19
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4470.299
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6080.301
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0380.888
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SOX11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSOX11
NameSRY (sex determining region Y)-box 11
Aliases SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11
Chromosomal Location2p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SOX11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSOX11
NameSRY (sex determining region Y)-box 11
Aliases SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11
Chromosomal Location2p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SOX11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SOX11.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSOX11
NameSRY (sex determining region Y)-box 11
Aliases SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11
Chromosomal Location2p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SOX11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSOX11
NameSRY (sex determining region Y)-box 11
Aliases SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11
Chromosomal Location2p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SOX11 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSOX11
NameSRY (sex determining region Y)-box 11
Aliases SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11
Chromosomal Location2p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SOX11 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSOX11
NameSRY (sex determining region Y)-box 11
Aliases SRY-related HMG-box gene 11; MRD27; SRY (sex-determining region Y)-box 11; Transcription factor SOX-11
Chromosomal Location2p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SOX11 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.