Summary | |
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Symbol | SPNS1 |
Name | spinster homolog 1 (Drosophila) |
Aliases | HSpin1; nrs; SPINL; PP2030; spinster-like protein 1; Protein spinster homolog 1 |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion inner membrane Multi-pass membrane protein Note=Colocalizes with SDHB. |
Domain |
PF07690 Major Facilitator Superfamily |
Function |
Sphingolipid transporter (By similarity). May be involved in necrotic or autophagic cell death. |
Biological Process |
GO:0003376 sphingosine-1-phosphate signaling pathway GO:0006869 lipid transport GO:0010876 lipid localization GO:0090520 sphingolipid mediated signaling pathway |
Molecular Function |
GO:0005319 lipid transporter activity GO:0046624 sphingolipid transporter activity |
Cellular Component |
GO:0005743 mitochondrial inner membrane GO:0005765 lysosomal membrane GO:0098852 lytic vacuole membrane |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | SPNS1 |
Name | spinster homolog 1 (Drosophila) |
Aliases | HSpin1; nrs; SPINL; PP2030; spinster-like protein 1; Protein spinster homolog 1 |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SPNS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SPNS1 |
Name | spinster homolog 1 (Drosophila) |
Aliases | HSpin1; nrs; SPINL; PP2030; spinster-like protein 1; Protein spinster homolog 1 |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SPNS1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | SPNS1 |
Name | spinster homolog 1 (Drosophila) |
Aliases | HSpin1; nrs; SPINL; PP2030; spinster-like protein 1; Protein spinster homolog 1 |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SPNS1 in various data sets.
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Points in the above scatter plot represent the mutation difference of SPNS1 in various data sets.
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Summary | |
---|---|
Symbol | SPNS1 |
Name | spinster homolog 1 (Drosophila) |
Aliases | HSpin1; nrs; SPINL; PP2030; spinster-like protein 1; Protein spinster homolog 1 |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SPNS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SPNS1 |
Name | spinster homolog 1 (Drosophila) |
Aliases | HSpin1; nrs; SPINL; PP2030; spinster-like protein 1; Protein spinster homolog 1 |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SPNS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SPNS1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SPNS1 |
Name | spinster homolog 1 (Drosophila) |
Aliases | HSpin1; nrs; SPINL; PP2030; spinster-like protein 1; Protein spinster homolog 1 |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SPNS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SPNS1 |
Name | spinster homolog 1 (Drosophila) |
Aliases | HSpin1; nrs; SPINL; PP2030; spinster-like protein 1; Protein spinster homolog 1 |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SPNS1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SPNS1 |
Name | spinster homolog 1 (Drosophila) |
Aliases | HSpin1; nrs; SPINL; PP2030; spinster-like protein 1; Protein spinster homolog 1 |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SPNS1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SPNS1 |
Name | spinster homolog 1 (Drosophila) |
Aliases | HSpin1; nrs; SPINL; PP2030; spinster-like protein 1; Protein spinster homolog 1 |
Chromosomal Location | 16p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SPNS1 collected from DrugBank database. |
There is no record. |