Browse ST20

Summary
SymbolST20
Namesuppressor of tumorigenicity 20
Aliases HCCS-1; cervical cancer suppressor-1; human cervical cancer suppressor gene 1 protein; Suppressor of tumorig ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain -
Function

May act as a tumor suppressor. Promotes apoptosis of cancer cells.

> Gene Ontology
 
Biological Process GO:0001836 release of cytochrome c from mitochondria
GO:0008053 mitochondrial fusion
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637 apoptotic mitochondrial changes
GO:0038034 signal transduction in absence of ligand
GO:0044801 single-organism membrane fusion
GO:0048284 organelle fusion
GO:0061025 membrane fusion
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
Molecular Function GO:0015267 channel activity
GO:0022803 passive transmembrane transporter activity
GO:0046982 protein heterodimerization activity
Cellular Component GO:0005741 mitochondrial outer membrane
GO:0019867 outer membrane
GO:0031968 organelle outer membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolST20
Namesuppressor of tumorigenicity 20
Aliases HCCS-1; cervical cancer suppressor-1; human cervical cancer suppressor gene 1 protein; Suppressor of tumorig ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ST20 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolST20
Namesuppressor of tumorigenicity 20
Aliases HCCS-1; cervical cancer suppressor-1; human cervical cancer suppressor gene 1 protein; Suppressor of tumorig ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ST20 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolST20
Namesuppressor of tumorigenicity 20
Aliases HCCS-1; cervical cancer suppressor-1; human cervical cancer suppressor gene 1 protein; Suppressor of tumorig ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ST20 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6310.0697
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.9030.528
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4470.727
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.9170.0479
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2960.736
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.6890.0676
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.7040.0308
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.9710.183
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.4120.601
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3540.791
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2710.877
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.3730.00879
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolST20
Namesuppressor of tumorigenicity 20
Aliases HCCS-1; cervical cancer suppressor-1; human cervical cancer suppressor gene 1 protein; Suppressor of tumorig ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ST20. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolST20
Namesuppressor of tumorigenicity 20
Aliases HCCS-1; cervical cancer suppressor-1; human cervical cancer suppressor gene 1 protein; Suppressor of tumorig ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ST20. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ST20.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolST20
Namesuppressor of tumorigenicity 20
Aliases HCCS-1; cervical cancer suppressor-1; human cervical cancer suppressor gene 1 protein; Suppressor of tumorig ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ST20. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolST20
Namesuppressor of tumorigenicity 20
Aliases HCCS-1; cervical cancer suppressor-1; human cervical cancer suppressor gene 1 protein; Suppressor of tumorig ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ST20 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolST20
Namesuppressor of tumorigenicity 20
Aliases HCCS-1; cervical cancer suppressor-1; human cervical cancer suppressor gene 1 protein; Suppressor of tumorig ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ST20 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolST20
Namesuppressor of tumorigenicity 20
Aliases HCCS-1; cervical cancer suppressor-1; human cervical cancer suppressor gene 1 protein; Suppressor of tumorig ......
Chromosomal Location15q25.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ST20 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.