Browse STAM

Summary
SymbolSTAM
Namesignal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Aliases STAM1; STAM-11; STAM-1; Signal transducing adapter molecule 1
Chromosomal Location10p14-p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Early endosome membrane Peripheral membrane protein Cytoplasmic side
Domain PF00018 SH3 domain
PF02809 Ubiquitin interaction motif
PF00790 VHS domain
Function

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

> Gene Ontology
 
Biological Process GO:0006887 exocytosis
GO:0006914 autophagy
GO:0007032 endosome organization
GO:0007033 vacuole organization
GO:0007034 vacuolar transport
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0016050 vesicle organization
GO:0016197 endosomal transport
GO:0017157 regulation of exocytosis
GO:0036257 multivesicular body organization
GO:0036258 multivesicular body assembly
GO:0038127 ERBB signaling pathway
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0045921 positive regulation of exocytosis
GO:0051047 positive regulation of secretion
GO:0060627 regulation of vesicle-mediated transport
GO:0071971 extracellular exosome assembly
GO:1901184 regulation of ERBB signaling pathway
GO:1901185 negative regulation of ERBB signaling pathway
GO:1902115 regulation of organelle assembly
GO:1903532 positive regulation of secretion by cell
GO:1903541 regulation of exosomal secretion
GO:1903543 positive regulation of exosomal secretion
GO:1903551 regulation of extracellular exosome assembly
GO:1990182 exosomal secretion
Molecular Function GO:0005070 SH3/SH2 adaptor activity
GO:0030674 protein binding, bridging
GO:0035591 signaling adaptor activity
GO:0060090 binding, bridging
Cellular Component GO:0005769 early endosome
GO:0010008 endosome membrane
GO:0031901 early endosome membrane
GO:0033565 ESCRT-0 complex
GO:0036452 ESCRT complex
GO:0044440 endosomal part
> KEGG and Reactome Pathway
 
KEGG hsa04144 Endocytosis
hsa04630 Jak-STAT signaling pathway
Reactome R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828: Clathrin-mediated endocytosis
R-HSA-5688426: Deubiquitination
R-HSA-1643685: Disease
R-HSA-182971: EGFR downregulation
R-HSA-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-5663205: Infectious disease
R-HSA-8875360: InlB-mediated entry of Listeria monocytogenes into host cell
R-HSA-8876384: Listeria monocytogenes entry into host cells
R-HSA-199991: Membrane Trafficking
R-HSA-392499: Metabolism of proteins
R-HSA-5689901: Metalloprotease DUBs
R-HSA-6807004: Negative regulation of MET activity
R-HSA-597592: Post-translational protein modification
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-6806834: Signaling by MET
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolSTAM
Namesignal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Aliases STAM1; STAM-11; STAM-1; Signal transducing adapter molecule 1
Chromosomal Location10p14-p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between STAM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSTAM
Namesignal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Aliases STAM1; STAM-11; STAM-1; Signal transducing adapter molecule 1
Chromosomal Location10p14-p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of STAM in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.51 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSTAM
Namesignal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Aliases STAM1; STAM-11; STAM-1; Signal transducing adapter molecule 1
Chromosomal Location10p14-p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of STAM in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3870.289
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.5650.759
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2630.836
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0260.929
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2840.869
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4220.852
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0080.984
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1190.942
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2390.901
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1550.891
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6940.646
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0390.54
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of STAM in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSTAM
Namesignal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Aliases STAM1; STAM-11; STAM-1; Signal transducing adapter molecule 1
Chromosomal Location10p14-p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of STAM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSTAM
Namesignal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Aliases STAM1; STAM-11; STAM-1; Signal transducing adapter molecule 1
Chromosomal Location10p14-p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of STAM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by STAM.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSTAM
Namesignal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Aliases STAM1; STAM-11; STAM-1; Signal transducing adapter molecule 1
Chromosomal Location10p14-p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of STAM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSTAM
Namesignal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Aliases STAM1; STAM-11; STAM-1; Signal transducing adapter molecule 1
Chromosomal Location10p14-p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of STAM expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSTAM
Namesignal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Aliases STAM1; STAM-11; STAM-1; Signal transducing adapter molecule 1
Chromosomal Location10p14-p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between STAM and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSTAM
Namesignal transducing adaptor molecule (SH3 domain and ITAM motif) 1
Aliases STAM1; STAM-11; STAM-1; Signal transducing adapter molecule 1
Chromosomal Location10p14-p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting STAM collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.