Browse SWAP70

Summary
SymbolSWAP70
NameSWAP switching B-cell complex 70kDa subunit
Aliases KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70
Chromosomal Location11p15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Cell membrane. Nucleus Cell projection, lamellipodium Cytoplasm, cytoskeleton Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448). In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448). Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760).
Domain PF00169 PH domain
Function

Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).

> Gene Ontology
 
Biological Process GO:0002200 somatic diversification of immune receptors
GO:0002204 somatic recombination of immunoglobulin genes involved in immune response
GO:0002208 somatic diversification of immunoglobulins involved in immune response
GO:0002250 adaptive immune response
GO:0002263 cell activation involved in immune response
GO:0002285 lymphocyte activation involved in immune response
GO:0002312 B cell activation involved in immune response
GO:0002366 leukocyte activation involved in immune response
GO:0002377 immunoglobulin production
GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response
GO:0002440 production of molecular mediator of immune response
GO:0002443 leukocyte mediated immunity
GO:0002449 lymphocyte mediated immunity
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002551 mast cell chemotaxis
GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus
GO:0002685 regulation of leukocyte migration
GO:0002687 positive regulation of leukocyte migration
GO:0002688 regulation of leukocyte chemotaxis
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0006310 DNA recombination
GO:0006470 protein dephosphorylation
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0007015 actin filament organization
GO:0007162 negative regulation of cell adhesion
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008064 regulation of actin polymerization or depolymerization
GO:0008154 actin polymerization or depolymerization
GO:0010639 negative regulation of organelle organization
GO:0016064 immunoglobulin mediated immune response
GO:0016311 dephosphorylation
GO:0016444 somatic cell DNA recombination
GO:0016445 somatic diversification of immunoglobulins
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0019724 B cell mediated immunity
GO:0022407 regulation of cell-cell adhesion
GO:0022408 negative regulation of cell-cell adhesion
GO:0030042 actin filament depolymerization
GO:0030335 positive regulation of cell migration
GO:0030595 leukocyte chemotaxis
GO:0030832 regulation of actin filament length
GO:0030834 regulation of actin filament depolymerization
GO:0030835 negative regulation of actin filament depolymerization
GO:0032103 positive regulation of response to external stimulus
GO:0032231 regulation of actin filament bundle assembly
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032535 regulation of cellular component size
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0032984 macromolecular complex disassembly
GO:0033627 cell adhesion mediated by integrin
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0033631 cell-cell adhesion mediated by integrin
GO:0033632 regulation of cell-cell adhesion mediated by integrin
GO:0033633 negative regulation of cell-cell adhesion mediated by integrin
GO:0035303 regulation of dephosphorylation
GO:0035304 regulation of protein dephosphorylation
GO:0035305 negative regulation of dephosphorylation
GO:0035308 negative regulation of protein dephosphorylation
GO:0040017 positive regulation of locomotion
GO:0042113 B cell activation
GO:0043241 protein complex disassembly
GO:0043242 negative regulation of protein complex disassembly
GO:0043244 regulation of protein complex disassembly
GO:0043624 cellular protein complex disassembly
GO:0044089 positive regulation of cellular component biogenesis
GO:0045190 isotype switching
GO:0050900 leukocyte migration
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0051017 actin filament bundle assembly
GO:0051261 protein depolymerization
GO:0051272 positive regulation of cellular component movement
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051493 regulation of cytoskeleton organization
GO:0051494 negative regulation of cytoskeleton organization
GO:0051495 positive regulation of cytoskeleton organization
GO:0055074 calcium ion homeostasis
GO:0060326 cell chemotaxis
GO:0060753 regulation of mast cell chemotaxis
GO:0060754 positive regulation of mast cell chemotaxis
GO:0061572 actin filament bundle organization
GO:0070262 peptidyl-serine dephosphorylation
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0090066 regulation of anatomical structure size
GO:0097529 myeloid leukocyte migration
GO:0097531 mast cell migration
GO:1901879 regulation of protein depolymerization
GO:1901880 negative regulation of protein depolymerization
GO:1902308 regulation of peptidyl-serine dephosphorylation
GO:1902309 negative regulation of peptidyl-serine dephosphorylation
GO:2000147 positive regulation of cell motility
Molecular Function GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0005913 cell-cell adherens junction
GO:0030027 lamellipodium
GO:0031252 cell leading edge
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolSWAP70
NameSWAP switching B-cell complex 70kDa subunit
Aliases KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70
Chromosomal Location11p15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SWAP70 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSWAP70
NameSWAP switching B-cell complex 70kDa subunit
Aliases KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70
Chromosomal Location11p15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SWAP70 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSWAP70
NameSWAP switching B-cell complex 70kDa subunit
Aliases KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70
Chromosomal Location11p15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SWAP70 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.6940.0344
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.4920.481
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1170.938
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0530.876
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5330.795
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7940.761
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2070.639
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0480.981
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.50.822
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.1670.377
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.050.289
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1360.066
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SWAP70 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSWAP70
NameSWAP switching B-cell complex 70kDa subunit
Aliases KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70
Chromosomal Location11p15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SWAP70. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSWAP70
NameSWAP switching B-cell complex 70kDa subunit
Aliases KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70
Chromosomal Location11p15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SWAP70. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SWAP70.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSWAP70
NameSWAP switching B-cell complex 70kDa subunit
Aliases KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70
Chromosomal Location11p15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SWAP70. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSWAP70
NameSWAP switching B-cell complex 70kDa subunit
Aliases KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70
Chromosomal Location11p15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SWAP70 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSWAP70
NameSWAP switching B-cell complex 70kDa subunit
Aliases KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70
Chromosomal Location11p15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SWAP70 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSWAP70
NameSWAP switching B-cell complex 70kDa subunit
Aliases KIAA0640; SWAP-70; HSPC321; Switch-associated protein 70
Chromosomal Location11p15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SWAP70 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.