Summary | |
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Symbol | SYCE1 |
Name | synaptonemal complex central element protein 1 |
Aliases | bA108K14.6; CT76; cancer/testis antigen 76; C10orf94; chromosome 10 open reading frame 94 |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Chromosome Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE2 in the central elements. |
Domain |
PF15233 Synaptonemal complex central element protein 1 |
Function |
Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination. |
Biological Process |
GO:0007059 chromosome segregation GO:0007126 meiotic nuclear division GO:0007127 meiosis I GO:0007129 synapsis GO:0007130 synaptonemal complex assembly GO:0045132 meiotic chromosome segregation GO:0045143 homologous chromosome segregation GO:0051321 meiotic cell cycle GO:0070192 chromosome organization involved in meiotic cell cycle GO:0070193 synaptonemal complex organization GO:0098813 nuclear chromosome segregation GO:1903046 meiotic cell cycle process |
Molecular Function | - |
Cellular Component |
GO:0000793 condensed chromosome GO:0000794 condensed nuclear chromosome GO:0000795 synaptonemal complex GO:0000801 central element GO:0044454 nuclear chromosome part |
KEGG | - |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-1500620: Meiosis R-HSA-1221632: Meiotic synapsis |
Summary | |
---|---|
Symbol | SYCE1 |
Name | synaptonemal complex central element protein 1 |
Aliases | bA108K14.6; CT76; cancer/testis antigen 76; C10orf94; chromosome 10 open reading frame 94 |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between SYCE1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | SYCE1 |
Name | synaptonemal complex central element protein 1 |
Aliases | bA108K14.6; CT76; cancer/testis antigen 76; C10orf94; chromosome 10 open reading frame 94 |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of SYCE1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | SYCE1 |
Name | synaptonemal complex central element protein 1 |
Aliases | bA108K14.6; CT76; cancer/testis antigen 76; C10orf94; chromosome 10 open reading frame 94 |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of SYCE1 in various data sets.
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Points in the above scatter plot represent the mutation difference of SYCE1 in various data sets.
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Summary | |
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Symbol | SYCE1 |
Name | synaptonemal complex central element protein 1 |
Aliases | bA108K14.6; CT76; cancer/testis antigen 76; C10orf94; chromosome 10 open reading frame 94 |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SYCE1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | SYCE1 |
Name | synaptonemal complex central element protein 1 |
Aliases | bA108K14.6; CT76; cancer/testis antigen 76; C10orf94; chromosome 10 open reading frame 94 |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SYCE1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SYCE1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | SYCE1 |
Name | synaptonemal complex central element protein 1 |
Aliases | bA108K14.6; CT76; cancer/testis antigen 76; C10orf94; chromosome 10 open reading frame 94 |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SYCE1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | SYCE1 |
Name | synaptonemal complex central element protein 1 |
Aliases | bA108K14.6; CT76; cancer/testis antigen 76; C10orf94; chromosome 10 open reading frame 94 |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of SYCE1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | SYCE1 |
Name | synaptonemal complex central element protein 1 |
Aliases | bA108K14.6; CT76; cancer/testis antigen 76; C10orf94; chromosome 10 open reading frame 94 |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between SYCE1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | SYCE1 |
Name | synaptonemal complex central element protein 1 |
Aliases | bA108K14.6; CT76; cancer/testis antigen 76; C10orf94; chromosome 10 open reading frame 94 |
Chromosomal Location | 10q26.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting SYCE1 collected from DrugBank database. |
There is no record. |