TISIDB

Summary
Symbol	TACR3
Name	tachykinin receptor 3
Aliases	NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location	4q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Domain	PF00001 7 transmembrane receptor (rhodopsin family)
Function	This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.

> Gene Ontology [ TOP ]
Biological Process	GO:0002027 regulation of heart rate GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003015 heart process GO:0006584 catecholamine metabolic process GO:0006936 muscle contraction GO:0006937 regulation of muscle contraction GO:0006939 smooth muscle contraction GO:0006940 regulation of smooth muscle contraction GO:0006970 response to osmotic stress GO:0006972 hyperosmotic response GO:0007217 tachykinin receptor signaling pathway GO:0007568 aging GO:0007631 feeding behavior GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0008217 regulation of blood pressure GO:0009308 amine metabolic process GO:0009651 response to salt stress GO:0009712 catechol-containing compound metabolic process GO:0010460 positive regulation of heart rate GO:0014072 response to isoquinoline alkaloid GO:0018958 phenol-containing compound metabolic process GO:0032355 response to estradiol GO:0033238 regulation of cellular amine metabolic process GO:0042053 regulation of dopamine metabolic process GO:0042069 regulation of catecholamine metabolic process GO:0042220 response to cocaine GO:0042417 dopamine metabolic process GO:0042538 hyperosmotic salinity response GO:0043278 response to morphine GO:0043279 response to alkaloid GO:0044057 regulation of system process GO:0044106 cellular amine metabolic process GO:0045777 positive regulation of blood pressure GO:0045823 positive regulation of heart contraction GO:0045933 positive regulation of muscle contraction GO:0045987 positive regulation of smooth muscle contraction GO:0050795 regulation of behavior GO:0060047 heart contraction GO:0060259 regulation of feeding behavior GO:0070471 uterine smooth muscle contraction GO:0070472 regulation of uterine smooth muscle contraction GO:0070474 positive regulation of uterine smooth muscle contraction GO:0090257 regulation of muscle system process GO:1901615 organic hydroxy compound metabolic process GO:1903522 regulation of blood circulation GO:1903524 positive regulation of blood circulation
Molecular Function	GO:0001653 peptide receptor activity GO:0004995 tachykinin receptor activity GO:0008188 neuropeptide receptor activity GO:0008528 G-protein coupled peptide receptor activity
Cellular Component	GO:0031252 cell leading edge GO:0031253 cell projection membrane GO:0031256 leading edge membrane GO:0032589 neuron projection membrane GO:0032590 dendrite membrane GO:0032809 neuronal cell body membrane GO:0043025 neuronal cell body GO:0044297 cell body GO:0044298 cell body membrane

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04020 Calcium signaling pathway hsa04080 Neuroactive ligand-receptor interaction
Reactome	R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-380095: Tachykinin receptors bind tachykinins

Summary
Symbol	TACR3
Name	tachykinin receptor 3
Aliases	NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location	4q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between TACR3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	TACR3
Name	tachykinin receptor 3
Aliases	NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location	4q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of TACR3 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	TACR3
Name	tachykinin receptor 3
Aliases	NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location	4q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of TACR3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0	1
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0	1
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0	1
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.115	0.839
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.297	0.784
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.121	0.918
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0	1
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0	1
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0	1
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0	1
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0	1
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.815	0.0108

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of TACR3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	14.3	0	14.3	0.196
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	20	0	20	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	11.1	6.8	4.3	0.443
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	11.1	8.5	2.6	0.702
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	14.3	17.6	-3.3	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	16.7	-16.7	0.429
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	23.1	18.2	4.9	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	TACR3
Name	tachykinin receptor 3
Aliases	NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location	4q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TACR3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	TACR3
Name	tachykinin receptor 3
Aliases	NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location	4q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TACR3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TACR3. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	TACR3
Name	tachykinin receptor 3
Aliases	NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location	4q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TACR3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	TACR3
Name	tachykinin receptor 3
Aliases	NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location	4q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of TACR3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	TACR3
Name	tachykinin receptor 3
Aliases	NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location	4q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between TACR3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	TACR3
Name	tachykinin receptor 3
Aliases	NK3R; neurokinin beta receptor; HH11; NK-3R; TAC3RL; NK-3 receptor; neurokinin B receptor; Neuromedin-K rece ......
Chromosomal Location	4q25
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting TACR3 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting TACR3.

ID	Name	Drug Type	Targets	#Targets
DB04872	Osanetant	Small Molecule	TACR3	1
DB06429	Talnetant	Small Molecule	TACR3	1

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