Browse TAF5

Summary
SymbolTAF5
NameTAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
Aliases TAFII100; TAF2D; TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD; TAF(II)100; ......
Chromosomal Location10q24-q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF04494 WD40 associated region in TFIID subunit
PF00400 WD domain
Function

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed.

> Gene Ontology
 
Biological Process GO:0006352 DNA-templated transcription, initiation
GO:0006354 DNA-templated transcription, elongation
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0009301 snRNA transcription
GO:0016073 snRNA metabolic process
GO:0016570 histone modification
GO:0016573 histone acetylation
GO:0018205 peptidyl-lysine modification
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0042795 snRNA transcription from RNA polymerase II promoter
GO:0043543 protein acylation
GO:0072331 signal transduction by p53 class mediator
GO:0098781 ncRNA transcription
GO:1901796 regulation of signal transduction by p53 class mediator
Molecular Function GO:0004402 histone acetyltransferase activity
GO:0008080 N-acetyltransferase activity
GO:0016407 acetyltransferase activity
GO:0016410 N-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0034212 peptide N-acetyltransferase activity
GO:0061733 peptide-lysine-N-acetyltransferase activity
Cellular Component GO:0000123 histone acetyltransferase complex
GO:0000428 DNA-directed RNA polymerase complex
GO:0005667 transcription factor complex
GO:0005669 transcription factor TFIID complex
GO:0015629 actin cytoskeleton
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0030880 RNA polymerase complex
GO:0031248 protein acetyltransferase complex
GO:0033276 transcription factor TFTC complex
GO:0044798 nuclear transcription factor complex
GO:0055029 nuclear DNA-directed RNA polymerase complex
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:0070461 SAGA-type complex
GO:0090575 RNA polymerase II transcription factor complex
GO:1902493 acetyltransferase complex
> KEGG and Reactome Pathway
 
KEGG hsa03022 Basal transcription factors
Reactome R-HSA-1643685: Disease
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-162906: HIV Infection
R-HSA-162587: HIV Life Cycle
R-HSA-167161: HIV Transcription Initiation
R-HSA-5663205: Infectious disease
R-HSA-162599: Late Phase of HIV Life Cycle
R-HSA-167162: RNA Polymerase II HIV Promoter Escape
R-HSA-674695: RNA Polymerase II Pre-transcription Events
R-HSA-73776: RNA Polymerase II Promoter Escape
R-HSA-73857: RNA Polymerase II Transcription
R-HSA-75953: RNA Polymerase II Transcription Initiation
R-HSA-76042: RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-73779: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-6807505: RNA polymerase II transcribes snRNA genes
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804756: Regulation of TP53 Activity through Phosphorylation
R-HSA-167172: Transcription of the HIV genome
R-HSA-3700989: Transcriptional Regulation by TP53
Summary
SymbolTAF5
NameTAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
Aliases TAFII100; TAF2D; TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD; TAF(II)100; ......
Chromosomal Location10q24-q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TAF5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolTAF5
NameTAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
Aliases TAFII100; TAF2D; TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD; TAF(II)100; ......
Chromosomal Location10q24-q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TAF5 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.89 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolTAF5
NameTAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
Aliases TAFII100; TAF2D; TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD; TAF(II)100; ......
Chromosomal Location10q24-q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TAF5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0120.947
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1850.755
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1580.744
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3480.307
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2080.869
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.5220.749
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3040.194
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0870.921
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5820.526
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3950.509
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4740.562
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1520.0231
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TAF5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.407.40.0709
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTAF5
NameTAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
Aliases TAFII100; TAF2D; TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD; TAF(II)100; ......
Chromosomal Location10q24-q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TAF5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTAF5
NameTAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
Aliases TAFII100; TAF2D; TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD; TAF(II)100; ......
Chromosomal Location10q24-q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TAF5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TAF5.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTAF5
NameTAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
Aliases TAFII100; TAF2D; TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD; TAF(II)100; ......
Chromosomal Location10q24-q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TAF5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTAF5
NameTAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
Aliases TAFII100; TAF2D; TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD; TAF(II)100; ......
Chromosomal Location10q24-q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TAF5 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTAF5
NameTAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
Aliases TAFII100; TAF2D; TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD; TAF(II)100; ......
Chromosomal Location10q24-q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TAF5 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTAF5
NameTAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
Aliases TAFII100; TAF2D; TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD; TAF(II)100; ......
Chromosomal Location10q24-q25.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TAF5 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.