TISIDB

Summary
Symbol	TFAM
Name	transcription factor A, mitochondrial
Aliases	TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location	10q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Mitochondrion Mitochondrion matrix, mitochondrion nucleoid
Domain	PF00505 HMG (high mobility group) box PF09011 HMG-box domain
Function	Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.

> Gene Ontology [ TOP ]
Biological Process	GO:0000959 mitochondrial RNA metabolic process GO:0006260 DNA replication GO:0006261 DNA-dependent DNA replication GO:0006352 DNA-templated transcription, initiation GO:0006356 regulation of transcription from RNA polymerase I promoter GO:0006360 transcription from RNA polymerase I promoter GO:0006390 transcription from mitochondrial promoter GO:0006391 transcription initiation from mitochondrial promoter GO:0033108 mitochondrial respiratory chain complex assembly
Molecular Function	GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001159 core promoter proximal region DNA binding GO:0001221 transcription cofactor binding GO:0001223 transcription coactivator binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003682 chromatin binding GO:0008134 transcription factor binding GO:0008301 DNA binding, bending GO:0031072 heat shock protein binding GO:0070363 mitochondrial light strand promoter sense binding
Cellular Component	GO:0005759 mitochondrial matrix GO:0009295 nucleoid GO:0042645 mitochondrial nucleoid

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-74160: Gene Expression R-HSA-1592230: Mitochondrial biogenesis R-HSA-163282: Mitochondrial transcription initiation R-HSA-1852241: Organelle biogenesis and maintenance R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-75944: Transcription from mitochondrial promoters R-HSA-2151201: Transcriptional activation of mitochondrial biogenesis

Summary
Symbol	TFAM
Name	transcription factor A, mitochondrial
Aliases	TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location	10q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between TFAM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between TFAM and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
29872558	Colon Carcinoma	Promote immunity	TFAM is a novel mediator of immunogenic cancer cell death. Importantly, the release of TFAM, a mitochondrial DAMP, by apoptotic cells may contribute to spautin-1-induced ICD via its action on the receptor AGER. This immunogenic effect of spautin-1-treated cancer cells was lost when TFAM or AGER were neutralized by specific antibodies.

Summary
Symbol	TFAM
Name	transcription factor A, mitochondrial
Aliases	TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location	10q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of TFAM in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	TFAM
Name	transcription factor A, mitochondrial
Aliases	TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location	10q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of TFAM in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.345	0.218
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.571	0.706
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.176	0.881
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.129	0.587
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.102	0.943
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.165	0.928
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.028	0.942
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.164	0.921
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.113	0.95
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.343	0.777
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.017	0.569
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.023	0.748

> Mutation difference between responders and non-responders [ TOP ]
There is no record.

Summary
Symbol	TFAM
Name	transcription factor A, mitochondrial
Aliases	TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location	10q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TFAM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	TFAM
Name	transcription factor A, mitochondrial
Aliases	TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location	10q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TFAM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TFAM. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	TFAM
Name	transcription factor A, mitochondrial
Aliases	TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location	10q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TFAM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	TFAM
Name	transcription factor A, mitochondrial
Aliases	TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location	10q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of TFAM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	TFAM
Name	transcription factor A, mitochondrial
Aliases	TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location	10q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between TFAM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	TFAM
Name	transcription factor A, mitochondrial
Aliases	TCF6; TCF6L2; MTTFA; mitochondrial transcription factor 1; mitochondrial transcription factor A; transcripti ......
Chromosomal Location	10q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting TFAM collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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