Summary | |
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Symbol | TGFB1 |
Name | transforming growth factor, beta 1 |
Aliases | TGFbeta; Camurati-Engelmann disease; prepro-transforming growth factor beta-1; TGFB; DPD1; TGF-beta-1; laten ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix |
Domain |
PF00019 Transforming growth factor beta like domain PF00688 TGF-beta propeptide |
Function |
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (PubMed:25310401). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed:25893292). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed:25893292). |
Biological Process |
GO:0000018 regulation of DNA recombination GO:0000060 protein import into nucleus, translocation GO:0000075 cell cycle checkpoint GO:0000271 polysaccharide biosynthetic process GO:0001501 skeletal system development GO:0001503 ossification GO:0001558 regulation of cell growth GO:0001570 vasculogenesis GO:0001654 eye development GO:0001655 urogenital system development GO:0001657 ureteric bud development GO:0001658 branching involved in ureteric bud morphogenesis GO:0001666 response to hypoxia GO:0001667 ameboidal-type cell migration GO:0001763 morphogenesis of a branching structure GO:0001773 myeloid dendritic cell activation GO:0001776 leukocyte homeostasis GO:0001818 negative regulation of cytokine production GO:0001819 positive regulation of cytokine production GO:0001822 kidney development GO:0001823 mesonephros development GO:0001837 epithelial to mesenchymal transition GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0001889 liver development GO:0001933 negative regulation of protein phosphorylation GO:0001974 blood vessel remodeling GO:0002028 regulation of sodium ion transport GO:0002062 chondrocyte differentiation GO:0002088 lens development in camera-type eye GO:0002200 somatic diversification of immune receptors GO:0002204 somatic recombination of immunoglobulin genes involved in immune response GO:0002208 somatic diversification of immunoglobulins involved in immune response GO:0002237 response to molecule of bacterial origin GO:0002244 hematopoietic progenitor cell differentiation GO:0002246 wound healing involved in inflammatory response GO:0002248 connective tissue replacement involved in inflammatory response wound healing GO:0002250 adaptive immune response GO:0002260 lymphocyte homeostasis GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002285 lymphocyte activation involved in immune response GO:0002312 B cell activation involved in immune response GO:0002366 leukocyte activation involved in immune response GO:0002367 cytokine production involved in immune response GO:0002377 immunoglobulin production GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002507 tolerance induction GO:0002513 tolerance induction to self antigen GO:0002521 leukocyte differentiation GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus GO:0002573 myeloid leukocyte differentiation GO:0002576 platelet degranulation GO:0002637 regulation of immunoglobulin production GO:0002639 positive regulation of immunoglobulin production GO:0002683 negative regulation of immune system process GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002698 negative regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002700 regulation of production of molecular mediator of immune response GO:0002701 negative regulation of production of molecular mediator of immune response GO:0002702 positive regulation of production of molecular mediator of immune response GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002712 regulation of B cell mediated immunity GO:0002714 positive regulation of B cell mediated immunity GO:0002718 regulation of cytokine production involved in immune response GO:0002719 negative regulation of cytokine production involved in immune response GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002889 regulation of immunoglobulin mediated immune response GO:0002891 positive regulation of immunoglobulin mediated immune response GO:0003007 heart morphogenesis GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0003170 heart valve development GO:0003179 heart valve morphogenesis GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003208 cardiac ventricle morphogenesis GO:0003229 ventricular cardiac muscle tissue development GO:0003231 cardiac ventricle development GO:0003401 axis elongation GO:0005976 polysaccharide metabolic process GO:0006022 aminoglycan metabolic process GO:0006023 aminoglycan biosynthetic process GO:0006024 glycosaminoglycan biosynthetic process GO:0006026 aminoglycan catabolic process GO:0006027 glycosaminoglycan catabolic process GO:0006109 regulation of carbohydrate metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006260 DNA replication GO:0006275 regulation of DNA replication GO:0006310 DNA recombination GO:0006417 regulation of translation GO:0006470 protein dephosphorylation GO:0006473 protein acetylation GO:0006475 internal protein amino acid acetylation GO:0006476 protein deacetylation GO:0006606 protein import into nucleus GO:0006611 protein export from nucleus GO:0006644 phospholipid metabolic process GO:0006754 ATP biosynthetic process GO:0006801 superoxide metabolic process GO:0006814 sodium ion transport GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006887 exocytosis GO:0006909 phagocytosis GO:0006913 nucleocytoplasmic transport GO:0007009 plasma membrane organization GO:0007050 cell cycle arrest GO:0007067 mitotic nuclear division GO:0007088 regulation of mitotic nuclear division GO:0007093 mitotic cell cycle checkpoint GO:0007096 regulation of exit from mitosis GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0007173 epidermal growth factor receptor signaling pathway GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007179 transforming growth factor beta receptor signaling pathway GO:0007182 common-partner SMAD protein phosphorylation GO:0007183 SMAD protein complex assembly GO:0007184 SMAD protein import into nucleus GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007219 Notch signaling pathway GO:0007272 ensheathment of neurons GO:0007346 regulation of mitotic cell cycle GO:0007405 neuroblast proliferation GO:0007406 negative regulation of neuroblast proliferation GO:0007423 sensory organ development GO:0007431 salivary gland development GO:0007435 salivary gland morphogenesis GO:0007492 endoderm development GO:0007507 heart development GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0007565 female pregnancy GO:0007568 aging GO:0007584 response to nutrient GO:0008015 blood circulation GO:0008156 negative regulation of DNA replication GO:0008354 germ cell migration GO:0008366 axon ensheathment GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009124 nucleoside monophosphate biosynthetic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009127 purine nucleoside monophosphate biosynthetic process GO:0009141 nucleoside triphosphate metabolic process GO:0009142 nucleoside triphosphate biosynthetic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009145 purine nucleoside triphosphate biosynthetic process GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009156 ribonucleoside monophosphate biosynthetic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009163 nucleoside biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009168 purine ribonucleoside monophosphate biosynthetic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009201 ribonucleoside triphosphate biosynthetic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0009206 purine ribonucleoside triphosphate biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0009306 protein secretion GO:0009314 response to radiation GO:0009612 response to mechanical stimulus GO:0009620 response to fungus GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009814 defense response, incompatible interaction GO:0009817 defense response to fungus, incompatible interaction GO:0009991 response to extracellular stimulus GO:0010001 glial cell differentiation GO:0010171 body morphogenesis GO:0010212 response to ionizing radiation GO:0010458 exit from mitosis GO:0010522 regulation of calcium ion transport into cytosol GO:0010523 negative regulation of calcium ion transport into cytosol GO:0010573 vascular endothelial growth factor production GO:0010574 regulation of vascular endothelial growth factor production GO:0010575 positive regulation of vascular endothelial growth factor production GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010596 negative regulation of endothelial cell migration GO:0010608 posttranscriptional regulation of gene expression GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010633 negative regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010712 regulation of collagen metabolic process GO:0010714 positive regulation of collagen metabolic process GO:0010715 regulation of extracellular matrix disassembly GO:0010716 negative regulation of extracellular matrix disassembly GO:0010717 regulation of epithelial to mesenchymal transition GO:0010718 positive regulation of epithelial to mesenchymal transition GO:0010721 negative regulation of cell development GO:0010742 macrophage derived foam cell differentiation GO:0010761 fibroblast migration GO:0010762 regulation of fibroblast migration GO:0010763 positive regulation of fibroblast migration GO:0010799 regulation of peptidyl-threonine phosphorylation GO:0010800 positive regulation of peptidyl-threonine phosphorylation GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010934 macrophage cytokine production GO:0010935 regulation of macrophage cytokine production GO:0010936 negative regulation of macrophage cytokine production GO:0010959 regulation of metal ion transport GO:0014003 oligodendrocyte development GO:0014020 primary neural tube formation GO:0014706 striated muscle tissue development GO:0015672 monovalent inorganic cation transport GO:0016049 cell growth GO:0016051 carbohydrate biosynthetic process GO:0016064 immunoglobulin mediated immune response GO:0016202 regulation of striated muscle tissue development GO:0016311 dephosphorylation GO:0016331 morphogenesis of embryonic epithelium GO:0016441 posttranscriptional gene silencing GO:0016444 somatic cell DNA recombination GO:0016445 somatic diversification of immunoglobulins GO:0016447 somatic recombination of immunoglobulin gene segments GO:0016458 gene silencing GO:0016570 histone modification GO:0016573 histone acetylation GO:0016575 histone deacetylation GO:0017015 regulation of transforming growth factor beta receptor signaling pathway GO:0017038 protein import GO:0017148 negative regulation of translation GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0018205 peptidyl-lysine modification GO:0018209 peptidyl-serine modification GO:0018210 peptidyl-threonine modification GO:0018212 peptidyl-tyrosine modification GO:0018393 internal peptidyl-lysine acetylation GO:0018394 peptidyl-lysine acetylation GO:0019048 modulation by virus of host morphology or physiology GO:0019049 evasion or tolerance of host defenses by virus GO:0019054 modulation by virus of host process GO:0019216 regulation of lipid metabolic process GO:0019724 B cell mediated immunity GO:0021782 glial cell development GO:0021915 neural tube development GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0022412 cellular process involved in reproduction in multicellular organism GO:0022612 gland morphogenesis GO:0022617 extracellular matrix disassembly GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030100 regulation of endocytosis GO:0030198 extracellular matrix organization GO:0030203 glycosaminoglycan metabolic process GO:0030212 hyaluronan metabolic process GO:0030213 hyaluronan biosynthetic process GO:0030214 hyaluronan catabolic process GO:0030217 T cell differentiation GO:0030278 regulation of ossification GO:0030279 negative regulation of ossification GO:0030282 bone mineralization GO:0030308 negative regulation of cell growth GO:0030335 positive regulation of cell migration GO:0030336 negative regulation of cell migration GO:0030500 regulation of bone mineralization GO:0030501 positive regulation of bone mineralization GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030879 mammary gland development GO:0031047 gene silencing by RNA GO:0031050 dsRNA fragmentation GO:0031056 regulation of histone modification GO:0031058 positive regulation of histone modification GO:0031063 regulation of histone deacetylation GO:0031065 positive regulation of histone deacetylation GO:0031099 regeneration GO:0031100 animal organ regeneration GO:0031214 biomineral tissue development GO:0031334 positive regulation of protein complex assembly GO:0031349 positive regulation of defense response GO:0031532 actin cytoskeleton reorganization GO:0031536 positive regulation of exit from mitosis GO:0031663 lipopolysaccharide-mediated signaling pathway GO:0031667 response to nutrient levels GO:0031960 response to corticosteroid GO:0032103 positive regulation of response to external stimulus GO:0032355 response to estradiol GO:0032386 regulation of intracellular transport GO:0032388 positive regulation of intracellular transport GO:0032496 response to lipopolysaccharide GO:0032570 response to progesterone GO:0032620 interleukin-17 production GO:0032627 interleukin-23 production GO:0032660 regulation of interleukin-17 production GO:0032667 regulation of interleukin-23 production GO:0032700 negative regulation of interleukin-17 production GO:0032740 positive regulation of interleukin-17 production GO:0032801 receptor catabolic process GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0032881 regulation of polysaccharide metabolic process GO:0032885 regulation of polysaccharide biosynthetic process GO:0032928 regulation of superoxide anion generation GO:0032930 positive regulation of superoxide anion generation GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032945 negative regulation of mononuclear cell proliferation GO:0032956 regulation of actin cytoskeleton organization GO:0032963 collagen metabolic process GO:0032964 collagen biosynthetic process GO:0032965 regulation of collagen biosynthetic process GO:0032967 positive regulation of collagen biosynthetic process GO:0032970 regulation of actin filament-based process GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033157 regulation of intracellular protein transport GO:0033273 response to vitamin GO:0033280 response to vitamin D GO:0033674 positive regulation of kinase activity GO:0034103 regulation of tissue remodeling GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0034250 positive regulation of cellular amide metabolic process GO:0034284 response to monosaccharide GO:0034330 cell junction organization GO:0034405 response to fluid shear stress GO:0034504 protein localization to nucleus GO:0034616 response to laminar fluid shear stress GO:0034762 regulation of transmembrane transport GO:0034763 negative regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0034766 negative regulation of ion transmembrane transport GO:0035051 cardiocyte differentiation GO:0035065 regulation of histone acetylation GO:0035066 positive regulation of histone acetylation GO:0035148 tube formation GO:0035194 posttranscriptional gene silencing by RNA GO:0035195 gene silencing by miRNA GO:0035196 production of miRNAs involved in gene silencing by miRNA GO:0035239 tube morphogenesis GO:0035272 exocrine system development GO:0035303 regulation of dephosphorylation GO:0035304 regulation of protein dephosphorylation GO:0035306 positive regulation of dephosphorylation GO:0035307 positive regulation of protein dephosphorylation GO:0035601 protein deacylation GO:0035821 modification of morphology or physiology of other organism GO:0035902 response to immobilization stress GO:0036293 response to decreased oxygen levels GO:0036314 response to sterol GO:0038127 ERBB signaling pathway GO:0040013 negative regulation of locomotion GO:0040017 positive regulation of locomotion GO:0040029 regulation of gene expression, epigenetic GO:0042063 gliogenesis GO:0042098 T cell proliferation GO:0042110 T cell activation GO:0042113 B cell activation GO:0042129 regulation of T cell proliferation GO:0042130 negative regulation of T cell proliferation GO:0042278 purine nucleoside metabolic process GO:0042306 regulation of protein import into nucleus GO:0042307 positive regulation of protein import into nucleus GO:0042326 negative regulation of phosphorylation GO:0042451 purine nucleoside biosynthetic process GO:0042455 ribonucleoside biosynthetic process GO:0042476 odontogenesis GO:0042481 regulation of odontogenesis GO:0042482 positive regulation of odontogenesis GO:0042493 response to drug GO:0042552 myelination GO:0042554 superoxide anion generation GO:0042692 muscle cell differentiation GO:0042695 thelarche GO:0043010 camera-type eye development GO:0043011 myeloid dendritic cell differentiation GO:0043029 T cell homeostasis GO:0043062 extracellular structure organization GO:0043112 receptor metabolic process GO:0043113 receptor clustering GO:0043114 regulation of vascular permeability GO:0043117 positive regulation of vascular permeability GO:0043254 regulation of protein complex assembly GO:0043255 regulation of carbohydrate biosynthetic process GO:0043271 negative regulation of ion transport GO:0043331 response to dsRNA GO:0043388 positive regulation of DNA binding GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0043434 response to peptide hormone GO:0043491 protein kinase B signaling GO:0043534 blood vessel endothelial cell migration GO:0043535 regulation of blood vessel endothelial cell migration GO:0043536 positive regulation of blood vessel endothelial cell migration GO:0043537 negative regulation of blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0043543 protein acylation GO:0043550 regulation of lipid kinase activity GO:0043551 regulation of phosphatidylinositol 3-kinase activity GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity GO:0043583 ear development GO:0043932 ossification involved in bone remodeling GO:0044003 modification by symbiont of host morphology or physiology GO:0044068 modulation by symbiont of host cellular process GO:0044089 positive regulation of cellular component biogenesis GO:0044236 multicellular organism metabolic process GO:0044246 regulation of multicellular organismal metabolic process GO:0044253 positive regulation of multicellular organismal metabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0044413 avoidance of host defenses GO:0044415 evasion or tolerance of host defenses GO:0044416 induction by symbiont of host defense response GO:0044706 multi-multicellular organism process GO:0044723 single-organism carbohydrate metabolic process GO:0044744 protein targeting to nucleus GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0045055 regulated exocytosis GO:0045066 regulatory T cell differentiation GO:0045136 development of secondary sexual characteristics GO:0045190 isotype switching GO:0045191 regulation of isotype switching GO:0045216 cell-cell junction organization GO:0045444 fat cell differentiation GO:0045445 myoblast differentiation GO:0045580 regulation of T cell differentiation GO:0045582 positive regulation of T cell differentiation GO:0045589 regulation of regulatory T cell differentiation GO:0045591 positive regulation of regulatory T cell differentiation GO:0045598 regulation of fat cell differentiation GO:0045599 negative regulation of fat cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045621 positive regulation of lymphocyte differentiation GO:0045661 regulation of myoblast differentiation GO:0045662 negative regulation of myoblast differentiation GO:0045727 positive regulation of translation GO:0045778 positive regulation of ossification GO:0045785 positive regulation of cell adhesion GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045806 negative regulation of endocytosis GO:0045830 positive regulation of isotype switching GO:0045834 positive regulation of lipid metabolic process GO:0045840 positive regulation of mitotic nuclear division GO:0045843 negative regulation of striated muscle tissue development GO:0045844 positive regulation of striated muscle tissue development GO:0045860 positive regulation of protein kinase activity GO:0045911 positive regulation of DNA recombination GO:0045912 negative regulation of carbohydrate metabolic process GO:0045926 negative regulation of growth GO:0045930 negative regulation of mitotic cell cycle GO:0045931 positive regulation of mitotic cell cycle GO:0046034 ATP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0046129 purine ribonucleoside biosynthetic process GO:0046390 ribose phosphate biosynthetic process GO:0046543 development of secondary female sexual characteristics GO:0046651 lymphocyte proliferation GO:0046730 induction of host immune response by virus GO:0046732 active induction of host immune response by virus GO:0046822 regulation of nucleocytoplasmic transport GO:0046824 positive regulation of nucleocytoplasmic transport GO:0046849 bone remodeling GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048146 positive regulation of fibroblast proliferation GO:0048290 isotype switching to IgA isotypes GO:0048296 regulation of isotype switching to IgA isotypes GO:0048298 positive regulation of isotype switching to IgA isotypes GO:0048514 blood vessel morphogenesis GO:0048535 lymph node development GO:0048545 response to steroid hormone GO:0048565 digestive tract development GO:0048568 embryonic organ development GO:0048634 regulation of muscle organ development GO:0048635 negative regulation of muscle organ development GO:0048636 positive regulation of muscle organ development GO:0048641 regulation of skeletal muscle tissue development GO:0048642 negative regulation of skeletal muscle tissue development GO:0048644 muscle organ morphogenesis GO:0048705 skeletal system morphogenesis GO:0048709 oligodendrocyte differentiation GO:0048732 gland development GO:0048738 cardiac muscle tissue development GO:0048754 branching morphogenesis of an epithelial tube GO:0048762 mesenchymal cell differentiation GO:0048771 tissue remodeling GO:0048839 inner ear development GO:0048872 homeostasis of number of cells GO:0050670 regulation of lymphocyte proliferation GO:0050672 negative regulation of lymphocyte proliferation GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050680 negative regulation of epithelial cell proliferation GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050764 regulation of phagocytosis GO:0050765 negative regulation of phagocytosis GO:0050768 negative regulation of neurogenesis GO:0050777 negative regulation of immune response GO:0050832 defense response to fungus GO:0050863 regulation of T cell activation GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050868 negative regulation of T cell activation GO:0050870 positive regulation of T cell activation GO:0050871 positive regulation of B cell activation GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051047 positive regulation of secretion GO:0051051 negative regulation of transport GO:0051052 regulation of DNA metabolic process GO:0051053 negative regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051101 regulation of DNA binding GO:0051145 smooth muscle cell differentiation GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051148 negative regulation of muscle cell differentiation GO:0051149 positive regulation of muscle cell differentiation GO:0051150 regulation of smooth muscle cell differentiation GO:0051152 positive regulation of smooth muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051155 positive regulation of striated muscle cell differentiation GO:0051168 nuclear export GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051208 sequestering of calcium ion GO:0051209 release of sequestered calcium ion into cytosol GO:0051216 cartilage development GO:0051222 positive regulation of protein transport GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051271 negative regulation of cellular component movement GO:0051272 positive regulation of cellular component movement GO:0051279 regulation of release of sequestered calcium ion into cytosol GO:0051280 negative regulation of release of sequestered calcium ion into cytosol GO:0051282 regulation of sequestering of calcium ion GO:0051283 negative regulation of sequestering of calcium ion GO:0051284 positive regulation of sequestering of calcium ion GO:0051302 regulation of cell division GO:0051384 response to glucocorticoid GO:0051480 regulation of cytosolic calcium ion concentration GO:0051493 regulation of cytoskeleton organization GO:0051668 localization within membrane GO:0051701 interaction with host GO:0051781 positive regulation of cell division GO:0051783 regulation of nuclear division GO:0051785 positive regulation of nuclear division GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051832 avoidance of defenses of other organism involved in symbiotic interaction GO:0051834 evasion or tolerance of defenses of other organism involved in symbiotic interaction GO:0051896 regulation of protein kinase B signaling GO:0051897 positive regulation of protein kinase B signaling GO:0051924 regulation of calcium ion transport GO:0051926 negative regulation of calcium ion transport GO:0051961 negative regulation of nervous system development GO:0052031 modulation by symbiont of host defense response GO:0052173 response to defenses of other organism involved in symbiotic interaction GO:0052200 response to host defenses GO:0052251 induction by organism of defense response of other organism involved in symbiotic interaction GO:0052255 modulation by organism of defense response of other organism involved in symbiotic interaction GO:0052509 positive regulation by symbiont of host defense response GO:0052510 positive regulation by organism of defense response of other organism involved in symbiotic interaction GO:0052552 modulation by organism of immune response of other organism involved in symbiotic interaction GO:0052553 modulation by symbiont of host immune response GO:0052564 response to immune response of other organism involved in symbiotic interaction GO:0052572 response to host immune response GO:0055007 cardiac muscle cell differentiation GO:0055008 cardiac muscle tissue morphogenesis GO:0055010 ventricular cardiac muscle tissue morphogenesis GO:0055024 regulation of cardiac muscle tissue development GO:0055025 positive regulation of cardiac muscle tissue development GO:0055074 calcium ion homeostasis GO:0055123 digestive system development GO:0060147 regulation of posttranscriptional gene silencing GO:0060149 negative regulation of posttranscriptional gene silencing GO:0060312 regulation of blood vessel remodeling GO:0060323 head morphogenesis GO:0060324 face development GO:0060325 face morphogenesis GO:0060348 bone development GO:0060349 bone morphogenesis GO:0060363 cranial suture morphogenesis GO:0060364 frontal suture morphogenesis GO:0060389 pathway-restricted SMAD protein phosphorylation GO:0060390 regulation of SMAD protein import into nucleus GO:0060391 positive regulation of SMAD protein import into nucleus GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation GO:0060395 SMAD protein signal transduction GO:0060401 cytosolic calcium ion transport GO:0060402 calcium ion transport into cytosol GO:0060415 muscle tissue morphogenesis GO:0060443 mammary gland morphogenesis GO:0060444 branching involved in mammary gland duct morphogenesis GO:0060485 mesenchyme development GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0060560 developmental growth involved in morphogenesis GO:0060562 epithelial tube morphogenesis GO:0060602 branch elongation of an epithelium GO:0060603 mammary gland duct morphogenesis GO:0060606 tube closure GO:0060627 regulation of vesicle-mediated transport GO:0060675 ureteric bud morphogenesis GO:0060688 regulation of morphogenesis of a branching structure GO:0060744 mammary gland branching involved in thelarche GO:0060751 branch elongation involved in mammary gland duct branching GO:0060762 regulation of branching involved in mammary gland duct morphogenesis GO:0060964 regulation of gene silencing by miRNA GO:0060965 negative regulation of gene silencing by miRNA GO:0060966 regulation of gene silencing by RNA GO:0060967 negative regulation of gene silencing by RNA GO:0060968 regulation of gene silencing GO:0060969 negative regulation of gene silencing GO:0060993 kidney morphogenesis GO:0061008 hepaticobiliary system development GO:0061035 regulation of cartilage development GO:0061082 myeloid leukocyte cytokine production GO:0061138 morphogenesis of a branching epithelium GO:0061180 mammary gland epithelium development GO:0061213 positive regulation of mesonephros development GO:0061217 regulation of mesonephros development GO:0061311 cell surface receptor signaling pathway involved in heart development GO:0061326 renal tubule development GO:0061333 renal tubule morphogenesis GO:0061351 neural precursor cell proliferation GO:0061448 connective tissue development GO:0061614 pri-miRNA transcription from RNA polymerase II promoter GO:0070167 regulation of biomineral tissue development GO:0070169 positive regulation of biomineral tissue development GO:0070306 lens fiber cell differentiation GO:0070482 response to oxygen levels GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070509 calcium ion import GO:0070588 calcium ion transmembrane transport GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070664 negative regulation of leukocyte proliferation GO:0070723 response to cholesterol GO:0070838 divalent metal ion transport GO:0070918 production of small RNA involved in gene silencing by RNA GO:0070920 regulation of production of small RNA involved in gene silencing by RNA GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0071214 cellular response to abiotic stimulus GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071260 cellular response to mechanical stimulus GO:0071359 cellular response to dsRNA GO:0071375 cellular response to peptide hormone stimulus GO:0071383 cellular response to steroid hormone stimulus GO:0071384 cellular response to corticosteroid stimulus GO:0071385 cellular response to glucocorticoid stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071478 cellular response to radiation GO:0071479 cellular response to ionizing radiation GO:0071496 cellular response to external stimulus GO:0071548 response to dexamethasone GO:0071549 cellular response to dexamethasone stimulus GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071593 lymphocyte aggregation GO:0071674 mononuclear cell migration GO:0071675 regulation of mononuclear cell migration GO:0071677 positive regulation of mononuclear cell migration GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072001 renal system development GO:0072006 nephron development GO:0072009 nephron epithelium development GO:0072028 nephron morphogenesis GO:0072073 kidney epithelium development GO:0072078 nephron tubule morphogenesis GO:0072080 nephron tubule development GO:0072088 nephron epithelium morphogenesis GO:0072089 stem cell proliferation GO:0072091 regulation of stem cell proliferation GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:0072171 mesonephric tubule morphogenesis GO:0072175 epithelial tube formation GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0072522 purine-containing compound biosynthetic process GO:0072593 reactive oxygen species metabolic process GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0075136 response to host GO:0075528 modulation by virus of host immune response GO:0085029 extracellular matrix assembly GO:0090068 positive regulation of cell cycle process GO:0090077 foam cell differentiation GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090183 regulation of kidney development GO:0090184 positive regulation of kidney development GO:0090189 regulation of branching involved in ureteric bud morphogenesis GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis GO:0090218 positive regulation of lipid kinase activity GO:0090279 regulation of calcium ion import GO:0090281 negative regulation of calcium ion import GO:0090287 regulation of cellular response to growth factor stimulus GO:0090288 negative regulation of cellular response to growth factor stimulus GO:0090311 regulation of protein deacetylation GO:0090312 positive regulation of protein deacetylation GO:0090316 positive regulation of intracellular protein transport GO:0090322 regulation of superoxide metabolic process GO:0090594 inflammatory response to wounding GO:0097028 dendritic cell differentiation GO:0097094 craniofacial suture morphogenesis GO:0097191 extrinsic apoptotic signaling pathway GO:0097305 response to alcohol GO:0097421 liver regeneration GO:0097553 calcium ion transmembrane import into cytosol GO:0097709 connective tissue replacement GO:0098542 defense response to other organism GO:0098732 macromolecule deacylation GO:1900125 regulation of hyaluronan biosynthetic process GO:1900126 negative regulation of hyaluronan biosynthetic process GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1901136 carbohydrate derivative catabolic process GO:1901201 regulation of extracellular matrix assembly GO:1901203 positive regulation of extracellular matrix assembly GO:1901293 nucleoside phosphate biosynthetic process GO:1901565 organonitrogen compound catabolic process GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901654 response to ketone GO:1901655 cellular response to ketone GO:1901657 glycosyl compound metabolic process GO:1901659 glycosyl compound biosynthetic process GO:1901664 regulation of NAD+ ADP-ribosyltransferase activity GO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity GO:1901861 regulation of muscle tissue development GO:1901862 negative regulation of muscle tissue development GO:1901863 positive regulation of muscle tissue development GO:1901983 regulation of protein acetylation GO:1901985 positive regulation of protein acetylation GO:1901987 regulation of cell cycle phase transition GO:1901989 positive regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1901992 positive regulation of mitotic cell cycle phase transition GO:1902105 regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1902275 regulation of chromatin organization GO:1902593 single-organism nuclear import GO:1902656 calcium ion import into cytosol GO:1902692 regulation of neuroblast proliferation GO:1902893 regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903038 negative regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903053 regulation of extracellular matrix organization GO:1903054 negative regulation of extracellular matrix organization GO:1903055 positive regulation of extracellular matrix organization GO:1903076 regulation of protein localization to plasma membrane GO:1903077 negative regulation of protein localization to plasma membrane GO:1903169 regulation of calcium ion transmembrane transport GO:1903170 negative regulation of calcium ion transmembrane transport GO:1903510 mucopolysaccharide metabolic process GO:1903532 positive regulation of secretion by cell GO:1903533 regulation of protein targeting GO:1903706 regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:1903725 regulation of phospholipid metabolic process GO:1903727 positive regulation of phospholipid metabolic process GO:1903729 regulation of plasma membrane organization GO:1903798 regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903828 negative regulation of cellular protein localization GO:1903829 positive regulation of cellular protein localization GO:1903844 regulation of cellular response to transforming growth factor beta stimulus GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus GO:1903909 regulation of receptor clustering GO:1903911 positive regulation of receptor clustering GO:1904062 regulation of cation transmembrane transport GO:1904063 negative regulation of cation transmembrane transport GO:1904375 regulation of protein localization to cell periphery GO:1904376 negative regulation of protein localization to cell periphery GO:1904589 regulation of protein import GO:1904591 positive regulation of protein import GO:1904888 cranial skeletal system development GO:1904951 positive regulation of establishment of protein localization GO:1905207 regulation of cardiocyte differentiation GO:1905209 positive regulation of cardiocyte differentiation GO:1905269 positive regulation of chromatin organization GO:1905313 transforming growth factor beta receptor signaling pathway involved in heart development GO:1905330 regulation of morphogenesis of an epithelium GO:1905332 positive regulation of morphogenesis of an epithelium GO:1990314 cellular response to insulin-like growth factor stimulus GO:1990402 embryonic liver development GO:1990778 protein localization to cell periphery GO:2000021 regulation of ion homeostasis GO:2000027 regulation of organ morphogenesis GO:2000146 negative regulation of cell motility GO:2000147 positive regulation of cell motility GO:2000177 regulation of neural precursor cell proliferation GO:2000178 negative regulation of neural precursor cell proliferation GO:2000249 regulation of actin cytoskeleton reorganization GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2000647 negative regulation of stem cell proliferation GO:2000677 regulation of transcription regulatory region DNA binding GO:2000679 positive regulation of transcription regulatory region DNA binding GO:2000725 regulation of cardiac muscle cell differentiation GO:2000727 positive regulation of cardiac muscle cell differentiation GO:2000756 regulation of peptidyl-lysine acetylation GO:2000758 positive regulation of peptidyl-lysine acetylation |
Molecular Function |
GO:0001948 glycoprotein binding GO:0003823 antigen binding GO:0005114 type II transforming growth factor beta receptor binding GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005160 transforming growth factor beta receptor binding GO:0008047 enzyme activator activity GO:0008083 growth factor activity GO:0019207 kinase regulator activity GO:0019209 kinase activator activity GO:0019887 protein kinase regulator activity GO:0030295 protein kinase activator activity GO:0034713 type I transforming growth factor beta receptor binding GO:0034714 type III transforming growth factor beta receptor binding GO:0043539 protein serine/threonine kinase activator activity GO:0046982 protein heterodimerization activity GO:0047485 protein N-terminus binding |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix GO:0005796 Golgi lumen GO:0005902 microvillus GO:0030141 secretory granule GO:0030424 axon GO:0031091 platelet alpha granule GO:0031093 platelet alpha granule lumen GO:0031983 vesicle lumen GO:0034774 secretory granule lumen GO:0043025 neuronal cell body GO:0044297 cell body GO:0060205 cytoplasmic membrane-bounded vesicle lumen GO:0072562 blood microparticle GO:0098858 actin-based cell projection GO:0099503 secretory vesicle |
KEGG |
hsa04010 MAPK signaling pathway hsa04060 Cytokine-cytokine receptor interaction hsa04068 FoxO signaling pathway hsa04110 Cell cycle hsa04144 Endocytosis hsa04350 TGF-beta signaling pathway hsa04380 Osteoclast differentiation hsa04390 Hippo signaling pathway hsa04672 Intestinal immune network for IgA production |
Reactome |
R-HSA-202733: Cell surface interactions at the vascular wall R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-5688426: Deubiquitination R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-2173788: Downregulation of TGF-beta receptor signaling R-HSA-3000178: ECM proteoglycans R-HSA-1566948: Elastic fibre formation R-HSA-1474244: Extracellular matrix organization R-HSA-109582: Hemostasis R-HSA-168253: Host Interactions with Influenza Factors R-HSA-168256: Immune System R-HSA-5663205: Infectious disease R-HSA-168254: Influenza Infection R-HSA-168277: Influenza Virus Induced Apoptosis R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-3304349: Loss of Function of SMAD2/3 in Cancer R-HSA-3656534: Loss of Function of TGFBR1 in Cancer R-HSA-3642278: Loss of Function of TGFBR2 in Cancer R-HSA-392499: Metabolism of proteins R-HSA-2129379: Molecules associated with elastic fibres R-HSA-3000171: Non-integrin membrane-ECM interactions R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-114608: Platelet degranulation R-HSA-597592: Post-translational protein modification R-HSA-76005: Response to elevated platelet cytosolic Ca2+ R-HSA-3315487: SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3304356: SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-162582: Signal Transduction R-HSA-449147: Signaling by Interleukins R-HSA-170834: Signaling by TGF-beta Receptor Complex R-HSA-3304351: Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3000170: Syndecan interactions R-HSA-2173789: TGF-beta receptor signaling activates SMADs R-HSA-2173791: TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-3656532: TGFBR1 KD Mutants in Cancer R-HSA-3656535: TGFBR1 LBD Mutants in Cancer R-HSA-3645790: TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3642279: TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-381340: Transcriptional regulation of white adipocyte differentiation R-HSA-5689603: UCH proteinases |
Summary | |
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Symbol | TGFB1 |
Name | transforming growth factor, beta 1 |
Aliases | TGFbeta; Camurati-Engelmann disease; prepro-transforming growth factor beta-1; TGFB; DPD1; TGF-beta-1; laten ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TGFB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between TGFB1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | TGFB1 |
Name | transforming growth factor, beta 1 |
Aliases | TGFbeta; Camurati-Engelmann disease; prepro-transforming growth factor beta-1; TGFB; DPD1; TGF-beta-1; laten ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TGFB1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TGFB1 |
Name | transforming growth factor, beta 1 |
Aliases | TGFbeta; Camurati-Engelmann disease; prepro-transforming growth factor beta-1; TGFB; DPD1; TGF-beta-1; laten ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TGFB1 in various data sets.
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Points in the above scatter plot represent the mutation difference of TGFB1 in various data sets.
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Summary | |
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Symbol | TGFB1 |
Name | transforming growth factor, beta 1 |
Aliases | TGFbeta; Camurati-Engelmann disease; prepro-transforming growth factor beta-1; TGFB; DPD1; TGF-beta-1; laten ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TGFB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TGFB1 |
Name | transforming growth factor, beta 1 |
Aliases | TGFbeta; Camurati-Engelmann disease; prepro-transforming growth factor beta-1; TGFB; DPD1; TGF-beta-1; laten ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TGFB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TGFB1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | TGFB1 |
Name | transforming growth factor, beta 1 |
Aliases | TGFbeta; Camurati-Engelmann disease; prepro-transforming growth factor beta-1; TGFB; DPD1; TGF-beta-1; laten ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TGFB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | TGFB1 |
Name | transforming growth factor, beta 1 |
Aliases | TGFbeta; Camurati-Engelmann disease; prepro-transforming growth factor beta-1; TGFB; DPD1; TGF-beta-1; laten ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TGFB1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TGFB1 |
Name | transforming growth factor, beta 1 |
Aliases | TGFbeta; Camurati-Engelmann disease; prepro-transforming growth factor beta-1; TGFB; DPD1; TGF-beta-1; laten ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TGFB1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | TGFB1 |
Name | transforming growth factor, beta 1 |
Aliases | TGFbeta; Camurati-Engelmann disease; prepro-transforming growth factor beta-1; TGFB; DPD1; TGF-beta-1; laten ...... |
Chromosomal Location | 19q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TGFB1 collected from DrugBank database. |
Details on drugs targeting TGFB1.
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