Browse TGFB2

Summary
SymbolTGFB2
Nametransforming growth factor, beta 2
Aliases prepro-transforming growth factor beta-2; LDS4; TGF-beta2; BSC-1 cell growth inhibitor; G-TSF; cetermin; gli ......
Chromosomal Location1q41
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00019 Transforming growth factor beta like domain
PF00688 TGF-beta propeptide
Function

TGF-beta 2 has suppressive effects on interleukin-2 dependent T-cell growth.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001502 cartilage condensation
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001558 regulation of cell growth
GO:0001654 eye development
GO:0001655 urogenital system development
GO:0001666 response to hypoxia
GO:0001667 ameboidal-type cell migration
GO:0001776 leukocyte homeostasis
GO:0001818 negative regulation of cytokine production
GO:0001822 kidney development
GO:0001837 epithelial to mesenchymal transition
GO:0001838 embryonic epithelial tube formation
GO:0001841 neural tube formation
GO:0001843 neural tube closure
GO:0001942 hair follicle development
GO:0001974 blood vessel remodeling
GO:0002260 lymphocyte homeostasis
GO:0002367 cytokine production involved in immune response
GO:0002440 production of molecular mediator of immune response
GO:0002576 platelet degranulation
GO:0002683 negative regulation of immune system process
GO:0002697 regulation of immune effector process
GO:0002698 negative regulation of immune effector process
GO:0002700 regulation of production of molecular mediator of immune response
GO:0002701 negative regulation of production of molecular mediator of immune response
GO:0002718 regulation of cytokine production involved in immune response
GO:0002719 negative regulation of cytokine production involved in immune response
GO:0003007 heart morphogenesis
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0003148 outflow tract septum morphogenesis
GO:0003149 membranous septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003170 heart valve development
GO:0003171 atrioventricular valve development
GO:0003177 pulmonary valve development
GO:0003179 heart valve morphogenesis
GO:0003181 atrioventricular valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003197 endocardial cushion development
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003203 endocardial cushion morphogenesis
GO:0003205 cardiac chamber development
GO:0003206 cardiac chamber morphogenesis
GO:0003208 cardiac ventricle morphogenesis
GO:0003209 cardiac atrium morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003229 ventricular cardiac muscle tissue development
GO:0003230 cardiac atrium development
GO:0003231 cardiac ventricle development
GO:0003272 endocardial cushion formation
GO:0003274 endocardial cushion fusion
GO:0003275 apoptotic process involved in outflow tract morphogenesis
GO:0003278 apoptotic process involved in heart morphogenesis
GO:0003279 cardiac septum development
GO:0003281 ventricular septum development
GO:0003283 atrial septum development
GO:0003284 septum primum development
GO:0003289 atrial septum primum morphogenesis
GO:0003407 neural retina development
GO:0006584 catecholamine metabolic process
GO:0006606 protein import into nucleus
GO:0006887 exocytosis
GO:0006913 nucleocytoplasmic transport
GO:0006924 activation-induced cell death of T cells
GO:0007009 plasma membrane organization
GO:0007050 cell cycle arrest
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007184 SMAD protein import into nucleus
GO:0007265 Ras protein signal transduction
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007423 sensory organ development
GO:0007431 salivary gland development
GO:0007435 salivary gland morphogenesis
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0007548 sex differentiation
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0008347 glial cell migration
GO:0008406 gonad development
GO:0008544 epidermis development
GO:0008584 male gonad development
GO:0009306 protein secretion
GO:0009712 catechol-containing compound metabolic process
GO:0009713 catechol-containing compound biosynthetic process
GO:0010002 cardioblast differentiation
GO:0010171 body morphogenesis
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010692 regulation of alkaline phosphatase activity
GO:0010693 negative regulation of alkaline phosphatase activity
GO:0010715 regulation of extracellular matrix disassembly
GO:0010717 regulation of epithelial to mesenchymal transition
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010921 regulation of phosphatase activity
GO:0010923 negative regulation of phosphatase activity
GO:0010934 macrophage cytokine production
GO:0010935 regulation of macrophage cytokine production
GO:0010936 negative regulation of macrophage cytokine production
GO:0014020 primary neural tube formation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014706 striated muscle tissue development
GO:0014855 striated muscle cell proliferation
GO:0016049 cell growth
GO:0016311 dephosphorylation
GO:0016331 morphogenesis of embryonic epithelium
GO:0017038 protein import
GO:0017145 stem cell division
GO:0018958 phenol-containing compound metabolic process
GO:0021700 developmental maturation
GO:0021915 neural tube development
GO:0022404 molting cycle process
GO:0022405 hair cycle process
GO:0022602 ovulation cycle process
GO:0022612 gland morphogenesis
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0030278 regulation of ossification
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030326 embryonic limb morphogenesis
GO:0030335 positive regulation of cell migration
GO:0030593 neutrophil chemotaxis
GO:0030595 leukocyte chemotaxis
GO:0031069 hair follicle morphogenesis
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032147 activation of protein kinase activity
GO:0032570 response to progesterone
GO:0032844 regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032906 transforming growth factor beta2 production
GO:0032909 regulation of transforming growth factor beta2 production
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0033002 muscle cell proliferation
GO:0033627 cell adhesion mediated by integrin
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0033630 positive regulation of cell adhesion mediated by integrin
GO:0033674 positive regulation of kinase activity
GO:0034330 cell junction organization
GO:0034504 protein localization to nucleus
GO:0035051 cardiocyte differentiation
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035265 organ growth
GO:0035272 exocrine system development
GO:0035303 regulation of dephosphorylation
GO:0035305 negative regulation of dephosphorylation
GO:0035904 aorta development
GO:0035905 ascending aorta development
GO:0035909 aorta morphogenesis
GO:0035910 ascending aorta morphogenesis
GO:0036293 response to decreased oxygen levels
GO:0038034 signal transduction in absence of ligand
GO:0040017 positive regulation of locomotion
GO:0042063 gliogenesis
GO:0042303 molting cycle
GO:0042416 dopamine biosynthetic process
GO:0042417 dopamine metabolic process
GO:0042423 catecholamine biosynthetic process
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0042633 hair cycle
GO:0042634 regulation of hair cycle
GO:0042635 positive regulation of hair cycle
GO:0042637 catagen
GO:0042698 ovulation cycle
GO:0042704 uterine wall breakdown
GO:0043010 camera-type eye development
GO:0043029 T cell homeostasis
GO:0043062 extracellular structure organization
GO:0043410 positive regulation of MAPK cascade
GO:0043523 regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043583 ear development
GO:0043588 skin development
GO:0044057 regulation of system process
GO:0044744 protein targeting to nucleus
GO:0044848 biological phase
GO:0044851 hair cycle phase
GO:0045055 regulated exocytosis
GO:0045112 integrin biosynthetic process
GO:0045113 regulation of integrin biosynthetic process
GO:0045137 development of primary sexual characteristics
GO:0045165 cell fate commitment
GO:0045216 cell-cell junction organization
GO:0045682 regulation of epidermis development
GO:0045684 positive regulation of epidermis development
GO:0045726 positive regulation of integrin biosynthetic process
GO:0045778 positive regulation of ossification
GO:0045785 positive regulation of cell adhesion
GO:0045786 negative regulation of cell cycle
GO:0045787 positive regulation of cell cycle
GO:0045823 positive regulation of heart contraction
GO:0045860 positive regulation of protein kinase activity
GO:0045926 negative regulation of growth
GO:0045927 positive regulation of growth
GO:0046189 phenol-containing compound biosynthetic process
GO:0046546 development of primary male sexual characteristics
GO:0046578 regulation of Ras protein signal transduction
GO:0046580 negative regulation of Ras protein signal transduction
GO:0046661 male sex differentiation
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048103 somatic stem cell division
GO:0048511 rhythmic process
GO:0048514 blood vessel morphogenesis
GO:0048545 response to steroid hormone
GO:0048565 digestive tract development
GO:0048566 embryonic digestive tract development
GO:0048568 embryonic organ development
GO:0048608 reproductive structure development
GO:0048644 muscle organ morphogenesis
GO:0048663 neuron fate commitment
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048705 skeletal system morphogenesis
GO:0048730 epidermis morphogenesis
GO:0048732 gland development
GO:0048736 appendage development
GO:0048738 cardiac muscle tissue development
GO:0048762 mesenchymal cell differentiation
GO:0048771 tissue remodeling
GO:0048818 positive regulation of hair follicle maturation
GO:0048819 regulation of hair follicle maturation
GO:0048820 hair follicle maturation
GO:0048839 inner ear development
GO:0048844 artery morphogenesis
GO:0048863 stem cell differentiation
GO:0048872 homeostasis of number of cells
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050777 negative regulation of immune response
GO:0050900 leukocyte migration
GO:0051047 positive regulation of secretion
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051058 negative regulation of small GTPase mediated signal transduction
GO:0051098 regulation of binding
GO:0051099 positive regulation of binding
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051216 cartilage development
GO:0051222 positive regulation of protein transport
GO:0051272 positive regulation of cellular component movement
GO:0051302 regulation of cell division
GO:0051346 negative regulation of hydrolase activity
GO:0051402 neuron apoptotic process
GO:0051403 stress-activated MAPK cascade
GO:0051493 regulation of cytoskeleton organization
GO:0051781 positive regulation of cell division
GO:0051794 regulation of catagen
GO:0051795 positive regulation of catagen
GO:0051797 regulation of hair follicle development
GO:0051798 positive regulation of hair follicle development
GO:0051890 regulation of cardioblast differentiation
GO:0051891 positive regulation of cardioblast differentiation
GO:0055008 cardiac muscle tissue morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0055017 cardiac muscle tissue growth
GO:0055123 digestive system development
GO:0060021 palate development
GO:0060037 pharyngeal system development
GO:0060038 cardiac muscle cell proliferation
GO:0060041 retina development in camera-type eye
GO:0060047 heart contraction
GO:0060065 uterus development
GO:0060173 limb development
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060323 head morphogenesis
GO:0060324 face development
GO:0060325 face morphogenesis
GO:0060326 cell chemotaxis
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation
GO:0060395 SMAD protein signal transduction
GO:0060411 cardiac septum morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060413 atrial septum morphogenesis
GO:0060415 muscle tissue morphogenesis
GO:0060419 heart growth
GO:0060485 mesenchyme development
GO:0060537 muscle tissue development
GO:0060561 apoptotic process involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060606 tube closure
GO:0060840 artery development
GO:0061035 regulation of cartilage development
GO:0061037 negative regulation of cartilage development
GO:0061082 myeloid leukocyte cytokine production
GO:0061343 cell adhesion involved in heart morphogenesis
GO:0061383 trabecula morphogenesis
GO:0061384 heart trabecula morphogenesis
GO:0061448 connective tissue development
GO:0061458 reproductive system development
GO:0061564 axon development
GO:0061626 pharyngeal arch artery morphogenesis
GO:0070227 lymphocyte apoptotic process
GO:0070228 regulation of lymphocyte apoptotic process
GO:0070230 positive regulation of lymphocyte apoptotic process
GO:0070231 T cell apoptotic process
GO:0070232 regulation of T cell apoptotic process
GO:0070234 positive regulation of T cell apoptotic process
GO:0070235 regulation of activation-induced cell death of T cells
GO:0070237 positive regulation of activation-induced cell death of T cells
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070482 response to oxygen levels
GO:0070997 neuron death
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071604 transforming growth factor beta production
GO:0071621 granulocyte chemotaxis
GO:0071634 regulation of transforming growth factor beta production
GO:0071695 anatomical structure maturation
GO:0071887 leukocyte apoptotic process
GO:0072001 renal system development
GO:0072132 mesenchyme morphogenesis
GO:0072175 epithelial tube formation
GO:0090091 positive regulation of extracellular matrix disassembly
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097485 neuron projection guidance
GO:0097529 myeloid leukocyte migration
GO:0097530 granulocyte migration
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
GO:0098743 cell aggregation
GO:0098773 skin epidermis development
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1901214 regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
GO:1901654 response to ketone
GO:1902256 regulation of apoptotic process involved in outflow tract morphogenesis
GO:1902337 regulation of apoptotic process involved in morphogenesis
GO:1902532 negative regulation of intracellular signal transduction
GO:1902593 single-organism nuclear import
GO:1902742 apoptotic process involved in development
GO:1903053 regulation of extracellular matrix organization
GO:1903055 positive regulation of extracellular matrix organization
GO:1903522 regulation of blood circulation
GO:1903524 positive regulation of blood circulation
GO:1903532 positive regulation of secretion by cell
GO:1903701 substantia propria of cornea development
GO:1903729 regulation of plasma membrane organization
GO:1903829 positive regulation of cellular protein localization
GO:1904424 regulation of GTP binding
GO:1904426 positive regulation of GTP binding
GO:1904748 regulation of apoptotic process involved in development
GO:1904888 cranial skeletal system development
GO:1904951 positive regulation of establishment of protein localization
GO:1905005 regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905006 negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905007 positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:1905207 regulation of cardiocyte differentiation
GO:1905209 positive regulation of cardiocyte differentiation
GO:1905314 semi-lunar valve development
GO:1990266 neutrophil migration
GO:2000027 regulation of organ morphogenesis
GO:2000106 regulation of leukocyte apoptotic process
GO:2000108 positive regulation of leukocyte apoptotic process
GO:2000147 positive regulation of cell motility
GO:2000736 regulation of stem cell differentiation
GO:2000738 positive regulation of stem cell differentiation
GO:2000826 regulation of heart morphogenesis
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Molecular Function GO:0001540 beta-amyloid binding
GO:0004674 protein serine/threonine kinase activity
GO:0004702 receptor signaling protein serine/threonine kinase activity
GO:0005057 receptor signaling protein activity
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005160 transforming growth factor beta receptor binding
GO:0008083 growth factor activity
GO:0033218 amide binding
GO:0034714 type III transforming growth factor beta receptor binding
GO:0042277 peptide binding
GO:0046982 protein heterodimerization activity
Cellular Component GO:0030141 secretory granule
GO:0030424 axon
GO:0031091 platelet alpha granule
GO:0031093 platelet alpha granule lumen
GO:0031983 vesicle lumen
GO:0034774 secretory granule lumen
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0060205 cytoplasmic membrane-bounded vesicle lumen
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04060 Cytokine-cytokine receptor interaction
hsa04068 FoxO signaling pathway
hsa04110 Cell cycle
hsa04144 Endocytosis
hsa04350 TGF-beta signaling pathway
hsa04380 Osteoclast differentiation
hsa04390 Hippo signaling pathway
Reactome R-HSA-3000178: ECM proteoglycans
R-HSA-1566948: Elastic fibre formation
R-HSA-1474244: Extracellular matrix organization
R-HSA-109582: Hemostasis
R-HSA-2129379: Molecules associated with elastic fibres
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-114608: Platelet degranulation
R-HSA-76005: Response to elevated platelet cytosolic Ca2+
Summary
SymbolTGFB2
Nametransforming growth factor, beta 2
Aliases prepro-transforming growth factor beta-2; LDS4; TGF-beta2; BSC-1 cell growth inhibitor; G-TSF; cetermin; gli ......
Chromosomal Location1q41
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TGFB2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between TGFB2 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
28911087Lung CarcinomaInhibit immunityAn antisense oligonucleotide targeting TGF-β2 inhibits lung metastasis and induces CD86 expression in tumor-associated macrophages. In addition, using an orthotopic xenograft model of a lung cancer cell line (CRL5807) that mainly expresses TGF-β2, we observed that ISTH0047 had an important effect on the lung microenvironment inhibiting the growth of lung lesions. ISTH0047 treatment re-educated macrophages in the lung parenchyma to express the tumor-suppressive factor, CD86.
17565341Cutaneous MelanomaInhibit immunityOur results indicate that tolerogenic DCs and suppressor T lymphocytes are present in melanoma at all stages of disease progression. In primary melanoma, TGFbeta2 is likely to render peripheral DCs tolerogenic, while in lymph nodes IDO and TGFbeta1 may have a major effect.
Summary
SymbolTGFB2
Nametransforming growth factor, beta 2
Aliases prepro-transforming growth factor beta-2; LDS4; TGF-beta2; BSC-1 cell growth inhibitor; G-TSF; cetermin; gli ......
Chromosomal Location1q41
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TGFB2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTGFB2
Nametransforming growth factor, beta 2
Aliases prepro-transforming growth factor beta-2; LDS4; TGF-beta2; BSC-1 cell growth inhibitor; G-TSF; cetermin; gli ......
Chromosomal Location1q41
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TGFB2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0420.928
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2730.738
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2730.685
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1420.754
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.320.831
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0840.964
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3730.507
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.2790.258
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.6690.573
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.3040.0834
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.5270.00635
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2750.115
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TGFB2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTGFB2
Nametransforming growth factor, beta 2
Aliases prepro-transforming growth factor beta-2; LDS4; TGF-beta2; BSC-1 cell growth inhibitor; G-TSF; cetermin; gli ......
Chromosomal Location1q41
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TGFB2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTGFB2
Nametransforming growth factor, beta 2
Aliases prepro-transforming growth factor beta-2; LDS4; TGF-beta2; BSC-1 cell growth inhibitor; G-TSF; cetermin; gli ......
Chromosomal Location1q41
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TGFB2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TGFB2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTGFB2
Nametransforming growth factor, beta 2
Aliases prepro-transforming growth factor beta-2; LDS4; TGF-beta2; BSC-1 cell growth inhibitor; G-TSF; cetermin; gli ......
Chromosomal Location1q41
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TGFB2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTGFB2
Nametransforming growth factor, beta 2
Aliases prepro-transforming growth factor beta-2; LDS4; TGF-beta2; BSC-1 cell growth inhibitor; G-TSF; cetermin; gli ......
Chromosomal Location1q41
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TGFB2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTGFB2
Nametransforming growth factor, beta 2
Aliases prepro-transforming growth factor beta-2; LDS4; TGF-beta2; BSC-1 cell growth inhibitor; G-TSF; cetermin; gli ......
Chromosomal Location1q41
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TGFB2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTGFB2
Nametransforming growth factor, beta 2
Aliases prepro-transforming growth factor beta-2; LDS4; TGF-beta2; BSC-1 cell growth inhibitor; G-TSF; cetermin; gli ......
Chromosomal Location1q41
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TGFB2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.