Browse TH

Summary
SymbolTH
Nametyrosine hydroxylase
Aliases DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF00351 Biopterin-dependent aromatic amino acid hydroxylase
PF12549 Tyrosine hydroxylase N terminal
Function

Plays an important role in the physiology of adrenergic neurons.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0001505 regulation of neurotransmitter levels
GO:0001654 eye development
GO:0001666 response to hypoxia
GO:0001678 cellular glucose homeostasis
GO:0001754 eye photoreceptor cell differentiation
GO:0001963 synaptic transmission, dopaminergic
GO:0001975 response to amphetamine
GO:0002237 response to molecule of bacterial origin
GO:0003007 heart morphogenesis
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0006570 tyrosine metabolic process
GO:0006584 catecholamine metabolic process
GO:0006585 dopamine biosynthetic process from tyrosine
GO:0006631 fatty acid metabolic process
GO:0006643 membrane lipid metabolic process
GO:0006665 sphingolipid metabolic process
GO:0006720 isoprenoid metabolic process
GO:0006836 neurotransmitter transport
GO:0006970 response to osmotic stress
GO:0007270 neuron-neuron synaptic transmission
GO:0007423 sensory organ development
GO:0007507 heart development
GO:0007568 aging
GO:0007601 visual perception
GO:0007605 sensory perception of sound
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0007617 mating behavior
GO:0007618 mating
GO:0007622 rhythmic behavior
GO:0007623 circadian rhythm
GO:0007626 locomotory behavior
GO:0007631 feeding behavior
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0009072 aromatic amino acid family metabolic process
GO:0009314 response to radiation
GO:0009404 toxin metabolic process
GO:0009414 response to water deprivation
GO:0009415 response to water
GO:0009416 response to light stimulus
GO:0009635 response to herbicide
GO:0009636 response to toxic substance
GO:0009651 response to salt stress
GO:0009712 catechol-containing compound metabolic process
GO:0009713 catechol-containing compound biosynthetic process
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009820 alkaloid metabolic process
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010042 response to manganese ion
GO:0010043 response to zinc ion
GO:0010259 multicellular organism aging
GO:0014075 response to amine
GO:0014823 response to activity
GO:0015837 amine transport
GO:0015842 aminergic neurotransmitter loading into synaptic vesicle
GO:0016137 glycoside metabolic process
GO:0017085 response to insecticide
GO:0018958 phenol-containing compound metabolic process
GO:0018963 phthalate metabolic process
GO:0019098 reproductive behavior
GO:0019748 secondary metabolic process
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021987 cerebral cortex development
GO:0030900 forebrain development
GO:0031076 embryonic camera-type eye development
GO:0031667 response to nutrient levels
GO:0031960 response to corticosteroid
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0033076 isoquinoline alkaloid metabolic process
GO:0033500 carbohydrate homeostasis
GO:0034284 response to monosaccharide
GO:0035094 response to nicotine
GO:0035176 social behavior
GO:0035690 cellular response to drug
GO:0035900 response to isolation stress
GO:0035902 response to immobilization stress
GO:0036293 response to decreased oxygen levels
GO:0042133 neurotransmitter metabolic process
GO:0042136 neurotransmitter biosynthetic process
GO:0042214 terpene metabolic process
GO:0042414 epinephrine metabolic process
GO:0042415 norepinephrine metabolic process
GO:0042416 dopamine biosynthetic process
GO:0042417 dopamine metabolic process
GO:0042418 epinephrine biosynthetic process
GO:0042421 norepinephrine biosynthetic process
GO:0042423 catecholamine biosynthetic process
GO:0042461 photoreceptor cell development
GO:0042462 eye photoreceptor cell development
GO:0042493 response to drug
GO:0042537 benzene-containing compound metabolic process
GO:0042593 glucose homeostasis
GO:0042745 circadian sleep/wake cycle
GO:0042755 eating behavior
GO:0043010 camera-type eye development
GO:0043279 response to alkaloid
GO:0043434 response to peptide hormone
GO:0043473 pigmentation
GO:0043648 dicarboxylic acid metabolic process
GO:0044057 regulation of system process
GO:0044708 single-organism behavior
GO:0045471 response to ethanol
GO:0045472 response to ether
GO:0046189 phenol-containing compound biosynthetic process
GO:0046530 photoreceptor cell differentiation
GO:0046684 response to pyrethroid
GO:0048048 embryonic eye morphogenesis
GO:0048511 rhythmic process
GO:0048512 circadian behavior
GO:0048545 response to steroid hormone
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048596 embryonic camera-type eye morphogenesis
GO:0050890 cognition
GO:0050953 sensory perception of light stimulus
GO:0050954 sensory perception of mechanical stimulus
GO:0051384 response to glucocorticoid
GO:0051385 response to mineralocorticoid
GO:0051412 response to corticosterone
GO:0051602 response to electrical stimulus
GO:0051703 intraspecies interaction between organisms
GO:0051705 multi-organism behavior
GO:0052314 phytoalexin metabolic process
GO:0060047 heart contraction
GO:0070482 response to oxygen levels
GO:0071241 cellular response to inorganic substance
GO:0071248 cellular response to metal ion
GO:0071287 cellular response to manganese ion
GO:0071312 cellular response to alkaloid
GO:0071316 cellular response to nicotine
GO:0071322 cellular response to carbohydrate stimulus
GO:0071326 cellular response to monosaccharide stimulus
GO:0071331 cellular response to hexose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0090596 sensory organ morphogenesis
GO:0097305 response to alcohol
GO:0098700 neurotransmitter loading into synaptic vesicle
GO:0099504 synaptic vesicle cycle
GO:1901605 alpha-amino acid metabolic process
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
GO:1901652 response to peptide
GO:1901654 response to ketone
GO:1901657 glycosyl compound metabolic process
GO:1903522 regulation of blood circulation
GO:1990267 response to transition metal nanoparticle
Molecular Function GO:0004497 monooxygenase activity
GO:0004511 tyrosine 3-monooxygenase activity
GO:0005506 iron ion binding
GO:0008198 ferrous iron binding
GO:0008199 ferric iron binding
GO:0016597 amino acid binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0019825 oxygen binding
GO:0031406 carboxylic acid binding
GO:0034617 tetrahydrobiopterin binding
GO:0035240 dopamine binding
GO:0043168 anion binding
GO:0048037 cofactor binding
GO:0050662 coenzyme binding
GO:1901338 catecholamine binding
Cellular Component GO:0005790 smooth endoplasmic reticulum
GO:0008021 synaptic vesicle
GO:0009898 cytoplasmic side of plasma membrane
GO:0030133 transport vesicle
GO:0030424 axon
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0033162 melanosome membrane
GO:0033267 axon part
GO:0042470 melanosome
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043204 perikaryon
GO:0043679 axon terminus
GO:0044297 cell body
GO:0044306 neuron projection terminus
GO:0045009 chitosome
GO:0048770 pigment granule
GO:0070382 exocytic vesicle
GO:0098552 side of membrane
GO:0098562 cytoplasmic side of membrane
GO:0098793 presynapse
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04728 Dopaminergic synapse
hsa04917 Prolactin signaling pathway
hsa00350 Tyrosine metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-209776: Amine-derived hormones
R-HSA-209905: Catecholamine biosynthesis
R-HSA-1430728: Metabolism
R-HSA-71291: Metabolism of amino acids and derivatives
Summary
SymbolTH
Nametyrosine hydroxylase
Aliases DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TH and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolTH
Nametyrosine hydroxylase
Aliases DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TH in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTH
Nametyrosine hydroxylase
Aliases DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TH in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.6790.443
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.890.537
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3930.79
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-1.4350.0358
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.6590.661
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-2.1930.216
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1450.744
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.1450.826
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2090.616
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TH in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTH
Nametyrosine hydroxylase
Aliases DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TH. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTH
Nametyrosine hydroxylase
Aliases DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TH. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TH.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTH
Nametyrosine hydroxylase
Aliases DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TH. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTH
Nametyrosine hydroxylase
Aliases DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TH expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTH
Nametyrosine hydroxylase
Aliases DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TH and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTH
Nametyrosine hydroxylase
Aliases DYT5b; tyrosine 3-monooxygenase; TYH; tyrosine 3-hydroxylase
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TH collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting TH.
ID Name Drug Type Targets #Targets
DB00120L-PhenylalanineSmall MoleculeFARS2, FARSA, FARSB, PAH, SLC7A8, TAT, TH7
DB00135L-TyrosineSmall MoleculeTAT, TH, YARS, YARS24
DB00360SapropterinSmall MoleculeNOS3, PAH, TH, TPH14
DB00765MetyrosineSmall MoleculeTH1
DB035523-TyrosineSmall MoleculeTH1
DB04400L-erythro-7,8-dihydrobiopterinSmall MoleculeNOS2, PAH, PCBD1, TH4