Browse THBS1

Summary
SymbolTHBS1
Namethrombospondin 1
Aliases THBS; TSP; THBS-1; TSP-1; thrombospondin-1p180; thrombospondin-p50; Thrombospondin-1
Chromosomal Location15q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum Sarcoplasmic reticulum
Domain PF00090 Thrombospondin type 1 domain
PF02412 Thrombospondin type 3 repeat
PF05735 Thrombospondin C-terminal region
PF00093 von Willebrand factor type C domain
Function

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).

> Gene Ontology
 
Biological Process GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0001666 response to hypoxia
GO:0001667 ameboidal-type cell migration
GO:0001818 negative regulation of cytokine production
GO:0001819 positive regulation of cytokine production
GO:0001935 endothelial cell proliferation
GO:0001936 regulation of endothelial cell proliferation
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001952 regulation of cell-matrix adhesion
GO:0001953 negative regulation of cell-matrix adhesion
GO:0002040 sprouting angiogenesis
GO:0002274 myeloid leukocyte activation
GO:0002468 dendritic cell antigen processing and presentation
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002544 chronic inflammatory response
GO:0002576 platelet degranulation
GO:0002577 regulation of antigen processing and presentation
GO:0002578 negative regulation of antigen processing and presentation
GO:0002580 regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002604 regulation of dendritic cell antigen processing and presentation
GO:0002605 negative regulation of dendritic cell antigen processing and presentation
GO:0002683 negative regulation of immune system process
GO:0002685 regulation of leukocyte migration
GO:0002687 positive regulation of leukocyte migration
GO:0002688 regulation of leukocyte chemotaxis
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0006140 regulation of nucleotide metabolic process
GO:0006417 regulation of translation
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0006820 anion transport
GO:0006869 lipid transport
GO:0006887 exocytosis
GO:0006909 phagocytosis
GO:0006911 phagocytosis, engulfment
GO:0006986 response to unfolded protein
GO:0007044 cell-substrate junction assembly
GO:0007045 cell-substrate adherens junction assembly
GO:0007050 cell cycle arrest
GO:0007160 cell-matrix adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007263 nitric oxide mediated signal transduction
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0009100 glycoprotein metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009187 cyclic nucleotide metabolic process
GO:0009266 response to temperature stimulus
GO:0009408 response to heat
GO:0009612 response to mechanical stimulus
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010324 membrane invagination
GO:0010466 negative regulation of peptidase activity
GO:0010594 regulation of endothelial cell migration
GO:0010595 positive regulation of endothelial cell migration
GO:0010596 negative regulation of endothelial cell migration
GO:0010608 posttranscriptional regulation of gene expression
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010633 negative regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010746 regulation of plasma membrane long-chain fatty acid transport
GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport
GO:0010749 regulation of nitric oxide mediated signal transduction
GO:0010751 negative regulation of nitric oxide mediated signal transduction
GO:0010752 regulation of cGMP-mediated signaling
GO:0010754 negative regulation of cGMP-mediated signaling
GO:0010755 regulation of plasminogen activation
GO:0010757 negative regulation of plasminogen activation
GO:0010758 regulation of macrophage chemotaxis
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010761 fibroblast migration
GO:0010762 regulation of fibroblast migration
GO:0010763 positive regulation of fibroblast migration
GO:0010810 regulation of cell-substrate adhesion
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010876 lipid localization
GO:0010951 negative regulation of endopeptidase activity
GO:0010955 negative regulation of protein processing
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0015849 organic acid transport
GO:0015908 fatty acid transport
GO:0015909 long-chain fatty acid transport
GO:0015911 plasma membrane long-chain fatty acid transport
GO:0016485 protein processing
GO:0016525 negative regulation of angiogenesis
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0018149 peptide cross-linking
GO:0019882 antigen processing and presentation
GO:0019932 second-messenger-mediated signaling
GO:0019934 cGMP-mediated signaling
GO:0019935 cyclic-nucleotide-mediated signaling
GO:0030193 regulation of blood coagulation
GO:0030194 positive regulation of blood coagulation
GO:0030195 negative regulation of blood coagulation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030595 leukocyte chemotaxis
GO:0030799 regulation of cyclic nucleotide metabolic process
GO:0030823 regulation of cGMP metabolic process
GO:0031589 cell-substrate adhesion
GO:0031638 zymogen activation
GO:0031639 plasminogen activation
GO:0032026 response to magnesium ion
GO:0032102 negative regulation of response to external stimulus
GO:0032103 positive regulation of response to external stimulus
GO:0032147 activation of protein kinase activity
GO:0032368 regulation of lipid transport
GO:0032369 negative regulation of lipid transport
GO:0032570 response to progesterone
GO:0032615 interleukin-12 production
GO:0032640 tumor necrosis factor production
GO:0032655 regulation of interleukin-12 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032695 negative regulation of interleukin-12 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032890 regulation of organic acid transport
GO:0032891 negative regulation of organic acid transport
GO:0032905 transforming growth factor beta1 production
GO:0032908 regulation of transforming growth factor beta1 production
GO:0032914 positive regulation of transforming growth factor beta1 production
GO:0033002 muscle cell proliferation
GO:0033555 multicellular organismal response to stress
GO:0033574 response to testosterone
GO:0033674 positive regulation of kinase activity
GO:0034248 regulation of cellular amide metabolic process
GO:0034250 positive regulation of cellular amide metabolic process
GO:0034284 response to monosaccharide
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0034332 adherens junction organization
GO:0034333 adherens junction assembly
GO:0034605 cellular response to heat
GO:0034612 response to tumor necrosis factor
GO:0034762 regulation of transmembrane transport
GO:0034763 negative regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034766 negative regulation of ion transmembrane transport
GO:0034976 response to endoplasmic reticulum stress
GO:0035767 endothelial cell chemotaxis
GO:0035966 response to topologically incorrect protein
GO:0036065 fucosylation
GO:0036066 protein O-linked fucosylation
GO:0036293 response to decreased oxygen levels
GO:0040013 negative regulation of locomotion
GO:0040017 positive regulation of locomotion
GO:0040036 regulation of fibroblast growth factor receptor signaling pathway
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042035 regulation of cytokine biosynthetic process
GO:0042089 cytokine biosynthetic process
GO:0042107 cytokine metabolic process
GO:0042108 positive regulation of cytokine biosynthetic process
GO:0042116 macrophage activation
GO:0042493 response to drug
GO:0042533 tumor necrosis factor biosynthetic process
GO:0042534 regulation of tumor necrosis factor biosynthetic process
GO:0042535 positive regulation of tumor necrosis factor biosynthetic process
GO:0042730 fibrinolysis
GO:0043030 regulation of macrophage activation
GO:0043032 positive regulation of macrophage activation
GO:0043062 extracellular structure organization
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043271 negative regulation of ion transport
GO:0043277 apoptotic cell clearance
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043413 macromolecule glycosylation
GO:0043491 protein kinase B signaling
GO:0043534 blood vessel endothelial cell migration
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043542 endothelial cell migration
GO:0043652 engulfment of apoptotic cell
GO:0044070 regulation of anion transport
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0044708 single-organism behavior
GO:0045055 regulated exocytosis
GO:0045216 cell-cell junction organization
GO:0045727 positive regulation of translation
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045786 negative regulation of cell cycle
GO:0045860 positive regulation of protein kinase activity
GO:0045861 negative regulation of proteolysis
GO:0046068 cGMP metabolic process
GO:0046942 carboxylic acid transport
GO:0048041 focal adhesion assembly
GO:0048246 macrophage chemotaxis
GO:0048265 response to pain
GO:0048266 behavioral response to pain
GO:0048514 blood vessel morphogenesis
GO:0048545 response to steroid hormone
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050817 coagulation
GO:0050818 regulation of coagulation
GO:0050819 negative regulation of coagulation
GO:0050820 positive regulation of coagulation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050878 regulation of body fluid levels
GO:0050900 leukocyte migration
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0050922 negative regulation of chemotaxis
GO:0051051 negative regulation of transport
GO:0051271 negative regulation of cellular component movement
GO:0051272 positive regulation of cellular component movement
GO:0051346 negative regulation of hydrolase activity
GO:0051592 response to calcium ion
GO:0051604 protein maturation
GO:0051893 regulation of focal adhesion assembly
GO:0051895 negative regulation of focal adhesion assembly
GO:0051896 regulation of protein kinase B signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0051917 regulation of fibrinolysis
GO:0051918 negative regulation of fibrinolysis
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0060326 cell chemotaxis
GO:0061041 regulation of wound healing
GO:0061045 negative regulation of wound healing
GO:0070085 glycosylation
GO:0070482 response to oxygen levels
GO:0070613 regulation of protein processing
GO:0071356 cellular response to tumor necrosis factor
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071604 transforming growth factor beta production
GO:0071621 granulocyte chemotaxis
GO:0071622 regulation of granulocyte chemotaxis
GO:0071634 regulation of transforming growth factor beta production
GO:0071636 positive regulation of transforming growth factor beta production
GO:0071674 mononuclear cell migration
GO:0071675 regulation of mononuclear cell migration
GO:0071706 tumor necrosis factor superfamily cytokine production
GO:0071774 response to fibroblast growth factor
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072577 endothelial cell apoptotic process
GO:0072593 reactive oxygen species metabolic process
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090109 regulation of cell-substrate junction assembly
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090288 negative regulation of cellular response to growth factor stimulus
GO:0090303 positive regulation of wound healing
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097529 myeloid leukocyte migration
GO:0097530 granulocyte migration
GO:0098656 anion transmembrane transport
GO:0099024 plasma membrane invagination
GO:1900046 regulation of hemostasis
GO:1900047 negative regulation of hemostasis
GO:1900048 positive regulation of hemostasis
GO:1900542 regulation of purine nucleotide metabolic process
GO:1901342 regulation of vasculature development
GO:1901343 negative regulation of vasculature development
GO:1901654 response to ketone
GO:1901888 regulation of cell junction assembly
GO:1901889 negative regulation of cell junction assembly
GO:1902001 fatty acid transmembrane transport
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902532 negative regulation of intracellular signal transduction
GO:1903034 regulation of response to wounding
GO:1903035 negative regulation of response to wounding
GO:1903036 positive regulation of response to wounding
GO:1903317 regulation of protein maturation
GO:1903318 negative regulation of protein maturation
GO:1903391 regulation of adherens junction organization
GO:1903392 negative regulation of adherens junction organization
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production
GO:1903792 negative regulation of anion transport
GO:1903825 organic acid transmembrane transport
GO:1903844 regulation of cellular response to transforming growth factor beta stimulus
GO:1903846 positive regulation of cellular response to transforming growth factor beta stimulus
GO:1903959 regulation of anion transmembrane transport
GO:1903960 negative regulation of anion transmembrane transport
GO:1904018 positive regulation of vasculature development
GO:1904019 epithelial cell apoptotic process
GO:1904035 regulation of epithelial cell apoptotic process
GO:1904037 positive regulation of epithelial cell apoptotic process
GO:1905039 carboxylic acid transmembrane transport
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2000146 negative regulation of cell motility
GO:2000147 positive regulation of cell motility
GO:2000181 negative regulation of blood vessel morphogenesis
GO:2000191 regulation of fatty acid transport
GO:2000192 negative regulation of fatty acid transport
GO:2000351 regulation of endothelial cell apoptotic process
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001026 regulation of endothelial cell chemotaxis
GO:2001027 negative regulation of endothelial cell chemotaxis
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Molecular Function GO:0001786 phosphatidylserine binding
GO:0001948 glycoprotein binding
GO:0001968 fibronectin binding
GO:0005178 integrin binding
GO:0005518 collagen binding
GO:0005539 glycosaminoglycan binding
GO:0005543 phospholipid binding
GO:0008201 heparin binding
GO:0017134 fibroblast growth factor binding
GO:0019838 growth factor binding
GO:0019955 cytokine binding
GO:0030169 low-density lipoprotein particle binding
GO:0043236 laminin binding
GO:0043394 proteoglycan binding
GO:0050431 transforming growth factor beta binding
GO:0050839 cell adhesion molecule binding
GO:0050840 extracellular matrix binding
GO:0070051 fibrinogen binding
GO:0070052 collagen V binding
GO:0071813 lipoprotein particle binding
GO:0071814 protein-lipid complex binding
GO:0072341 modified amino acid binding
GO:1901681 sulfur compound binding
Cellular Component GO:0005577 fibrinogen complex
GO:0005788 endoplasmic reticulum lumen
GO:0009897 external side of plasma membrane
GO:0016528 sarcoplasm
GO:0016529 sarcoplasmic reticulum
GO:0030141 secretory granule
GO:0031091 platelet alpha granule
GO:0031093 platelet alpha granule lumen
GO:0031983 vesicle lumen
GO:0034774 secretory granule lumen
GO:0060205 cytoplasmic membrane-bounded vesicle lumen
GO:0098552 side of membrane
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04015 Rap1 signaling pathway
hsa04115 p53 signaling pathway
hsa04145 Phagosome
hsa04151 PI3K-Akt signaling pathway
hsa04350 TGF-beta signaling pathway
hsa04510 Focal adhesion
hsa04512 ECM-receptor interaction
Reactome R-HSA-5083635: Defective B3GALTL causes Peters-plus syndrome (PpS)
R-HSA-1643685: Disease
R-HSA-3906995: Diseases associated with O-glycosylation of proteins
R-HSA-3781865: Diseases of glycosylation
R-HSA-1474244: Extracellular matrix organization
R-HSA-109582: Hemostasis
R-HSA-216083: Integrin cell surface interactions
R-HSA-392499: Metabolism of proteins
R-HSA-3000171: Non-integrin membrane-ECM interactions
R-HSA-5173214: O-glycosylation of TSR domain-containing proteins
R-HSA-5173105: O-linked glycosylation
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-114608: Platelet degranulation
R-HSA-597592: Post-translational protein modification
R-HSA-76005: Response to elevated platelet cytosolic Ca2+
R-HSA-162582: Signal Transduction
R-HSA-186797: Signaling by PDGF
R-HSA-3000170: Syndecan interactions
Summary
SymbolTHBS1
Namethrombospondin 1
Aliases THBS; TSP; THBS-1; TSP-1; thrombospondin-1p180; thrombospondin-p50; Thrombospondin-1
Chromosomal Location15q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between THBS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between THBS1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
25697354Lung CarcinomaPromote immunityExogenous treatment of TSP-1 may be able to suppress the CD47-mediated tumor immune escape by disrupting the CD47-SIRP-a interaction. With the increasing surface expression of CD47, this suppression effect may be even more obvious in immune-selected cells. These findings prove that the TSP-1/CD47/SIRP-α signal axis is important to the evolution of tumor cells in the microenvironment of immunotherapy and identify thrombospondin-1 as a key signal with therapeutic benefits in overcoming long term relapse, providing new evidence for the clinical promise of cancer vaccination.
Summary
SymbolTHBS1
Namethrombospondin 1
Aliases THBS; TSP; THBS-1; TSP-1; thrombospondin-1p180; thrombospondin-p50; Thrombospondin-1
Chromosomal Location15q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of THBS1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTHBS1
Namethrombospondin 1
Aliases THBS; TSP; THBS-1; TSP-1; thrombospondin-1p180; thrombospondin-p50; Thrombospondin-1
Chromosomal Location15q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of THBS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.8270.149
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.0170.625
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6790.633
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.6970.282
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.2520.717
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0150.997
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2490.704
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3350.862
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2150.917
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.0390.634
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.7540.569
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4420.0157
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of THBS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.44.13.30.61
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.3014.30.238
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 512200200.294
Summary
SymbolTHBS1
Namethrombospondin 1
Aliases THBS; TSP; THBS-1; TSP-1; thrombospondin-1p180; thrombospondin-p50; Thrombospondin-1
Chromosomal Location15q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of THBS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTHBS1
Namethrombospondin 1
Aliases THBS; TSP; THBS-1; TSP-1; thrombospondin-1p180; thrombospondin-p50; Thrombospondin-1
Chromosomal Location15q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of THBS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by THBS1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTHBS1
Namethrombospondin 1
Aliases THBS; TSP; THBS-1; TSP-1; thrombospondin-1p180; thrombospondin-p50; Thrombospondin-1
Chromosomal Location15q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of THBS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTHBS1
Namethrombospondin 1
Aliases THBS; TSP; THBS-1; TSP-1; thrombospondin-1p180; thrombospondin-p50; Thrombospondin-1
Chromosomal Location15q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of THBS1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTHBS1
Namethrombospondin 1
Aliases THBS; TSP; THBS-1; TSP-1; thrombospondin-1p180; thrombospondin-p50; Thrombospondin-1
Chromosomal Location15q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between THBS1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTHBS1
Namethrombospondin 1
Aliases THBS; TSP; THBS-1; TSP-1; thrombospondin-1p180; thrombospondin-p50; Thrombospondin-1
Chromosomal Location15q15
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting THBS1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.