Browse TMED2

Summary
SymbolTMED2
Nametransmembrane p24 trafficking protein 2
Aliases RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasmic vesicle membrane Single-pass type I membrane protein Cytoplasmic vesicle, COPI-coated vesicle membrane Single-pass type I membrane protein Golgi apparatus, cis-Golgi network membrane Single-pass type I membrane protein Golgi apparatus, Golgi stack membrane Single-pass type I membrane protein Endoplasmic reticulum membrane Single-pass type I membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane Single-pass type I membrane protein Note=Cycles between compartments of the early secretatory pathway.
Domain PF01105 emp24/gp25L/p24 family/GOLD
Function

Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing.

> Gene Ontology
 
Biological Process GO:0000578 embryonic axis specification
GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0001838 embryonic epithelial tube formation
GO:0001841 neural tube formation
GO:0001843 neural tube closure
GO:0001890 placenta development
GO:0001892 embryonic placenta development
GO:0001893 maternal placenta development
GO:0001947 heart looping
GO:0003002 regionalization
GO:0003007 heart morphogenesis
GO:0003143 embryonic heart tube morphogenesis
GO:0006612 protein targeting to membrane
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0006900 membrane budding
GO:0006901 vesicle coating
GO:0006903 vesicle targeting
GO:0007009 plasma membrane organization
GO:0007030 Golgi organization
GO:0007368 determination of left/right symmetry
GO:0007389 pattern specification process
GO:0007507 heart development
GO:0007565 female pregnancy
GO:0009798 axis specification
GO:0009799 specification of symmetry
GO:0009855 determination of bilateral symmetry
GO:0009880 embryonic pattern specification
GO:0009948 anterior/posterior axis specification
GO:0009952 anterior/posterior pattern specification
GO:0014020 primary neural tube formation
GO:0016050 vesicle organization
GO:0016331 morphogenesis of embryonic epithelium
GO:0021915 neural tube development
GO:0032525 somite rostral/caudal axis specification
GO:0034260 negative regulation of GTPase activity
GO:0035050 embryonic heart tube development
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035264 multicellular organism growth
GO:0035282 segmentation
GO:0035459 cargo loading into vesicle
GO:0035964 COPI-coated vesicle budding
GO:0036342 post-anal tail morphogenesis
GO:0044706 multi-multicellular organism process
GO:0048193 Golgi vesicle transport
GO:0048194 Golgi vesicle budding
GO:0048199 vesicle targeting, to, from or within Golgi
GO:0048200 Golgi transport vesicle coating
GO:0048205 COPI coating of Golgi vesicle
GO:0048207 vesicle targeting, rough ER to cis-Golgi
GO:0048208 COPII vesicle coating
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048608 reproductive structure development
GO:0051346 negative regulation of hydrolase activity
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0060135 maternal process involved in female pregnancy
GO:0060562 epithelial tube morphogenesis
GO:0060606 tube closure
GO:0060674 placenta blood vessel development
GO:0060711 labyrinthine layer development
GO:0060716 labyrinthine layer blood vessel development
GO:0061053 somite development
GO:0061371 determination of heart left/right asymmetry
GO:0061458 reproductive system development
GO:0072175 epithelial tube formation
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0072661 protein targeting to plasma membrane
GO:0090002 establishment of protein localization to plasma membrane
GO:0090114 COPII-coated vesicle budding
GO:0090150 establishment of protein localization to membrane
GO:1990778 protein localization to cell periphery
Molecular Function -
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005795 Golgi stack
GO:0005798 Golgi-associated vesicle
GO:0012507 ER to Golgi transport vesicle membrane
GO:0030133 transport vesicle
GO:0030134 ER to Golgi transport vesicle
GO:0030135 coated vesicle
GO:0030137 COPI-coated vesicle
GO:0030141 secretory granule
GO:0030658 transport vesicle membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0030660 Golgi-associated vesicle membrane
GO:0030662 coated vesicle membrane
GO:0030663 COPI-coated vesicle membrane
GO:0030667 secretory granule membrane
GO:0031984 organelle subcompartment
GO:0031985 Golgi cisterna
GO:0032580 Golgi cisterna membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0042588 zymogen granule
GO:0042589 zymogen granule membrane
GO:0098791 Golgi subcompartment
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-446203: Asparagine N-linked glycosylation
R-HSA-6811434: COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6807878: COPI-mediated anterograde transport
R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport
R-HSA-5694530: Cargo concentration in the ER
R-HSA-199977: ER to Golgi Anterograde Transport
R-HSA-8856688: Golgi-to-ER retrograde transport
R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991: Membrane Trafficking
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-1912422: Pre-NOTCH Expression and Processing
R-HSA-1912420: Pre-NOTCH Processing in Golgi
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-948021: Transport to the Golgi and subsequent modification
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolTMED2
Nametransmembrane p24 trafficking protein 2
Aliases RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TMED2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolTMED2
Nametransmembrane p24 trafficking protein 2
Aliases RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TMED2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.15; FDR: 0.04220 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolTMED2
Nametransmembrane p24 trafficking protein 2
Aliases RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TMED2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1320.561
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3440.918
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0260.991
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1340.659
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4270.852
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2390.936
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1280.802
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2360.918
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0150.995
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0080.997
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2750.931
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2060.00111
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolTMED2
Nametransmembrane p24 trafficking protein 2
Aliases RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TMED2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTMED2
Nametransmembrane p24 trafficking protein 2
Aliases RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TMED2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TMED2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTMED2
Nametransmembrane p24 trafficking protein 2
Aliases RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TMED2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTMED2
Nametransmembrane p24 trafficking protein 2
Aliases RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TMED2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTMED2
Nametransmembrane p24 trafficking protein 2
Aliases RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TMED2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTMED2
Nametransmembrane p24 trafficking protein 2
Aliases RNP24; P24A; p24beta1; p24b1; transmembrane emp24 domain trafficking protein 2; coated vesicle membrane prot ......
Chromosomal Location12q24.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TMED2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.