TISIDB

Summary
Symbol	TNNC1
Name	troponin C type 1 (slow)
Aliases	TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location	3p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	-
Domain	PF13499 EF-hand domain pair PF13833 EF-hand domain pair
Function	Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

> Gene Ontology [ TOP ]
Biological Process	GO:0002086 diaphragm contraction GO:0003007 heart morphogenesis GO:0003009 skeletal muscle contraction GO:0003011 involuntary skeletal muscle contraction GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003015 heart process GO:0003016 respiratory system process GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003208 cardiac ventricle morphogenesis GO:0003229 ventricular cardiac muscle tissue development GO:0003231 cardiac ventricle development GO:0006936 muscle contraction GO:0006937 regulation of muscle contraction GO:0006941 striated muscle contraction GO:0007507 heart development GO:0007517 muscle organ development GO:0007585 respiratory gaseous exchange GO:0008015 blood circulation GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0014706 striated muscle tissue development GO:0014733 regulation of skeletal muscle adaptation GO:0014883 transition between fast and slow fiber GO:0014888 striated muscle adaptation GO:0030048 actin filament-based movement GO:0030049 muscle filament sliding GO:0032386 regulation of intracellular transport GO:0032970 regulation of actin filament-based process GO:0032971 regulation of muscle filament sliding GO:0032972 regulation of muscle filament sliding speed GO:0033275 actin-myosin filament sliding GO:0043462 regulation of ATPase activity GO:0043500 muscle adaptation GO:0043501 skeletal muscle adaptation GO:0043502 regulation of muscle adaptation GO:0044057 regulation of system process GO:0048644 muscle organ morphogenesis GO:0048738 cardiac muscle tissue development GO:0050879 multicellular organismal movement GO:0050881 musculoskeletal movement GO:0055008 cardiac muscle tissue morphogenesis GO:0055010 ventricular cardiac muscle tissue morphogenesis GO:0060047 heart contraction GO:0060048 cardiac muscle contraction GO:0060415 muscle tissue morphogenesis GO:0060537 muscle tissue development GO:0070252 actin-mediated cell contraction GO:0090257 regulation of muscle system process GO:1903115 regulation of actin filament-based movement
Molecular Function	GO:0003779 actin binding GO:0031013 troponin I binding GO:0031014 troponin T binding GO:0048306 calcium-dependent protein binding GO:0051015 actin filament binding
Cellular Component	GO:0005861 troponin complex GO:0005865 striated muscle thin filament GO:0015629 actin cytoskeleton GO:0030016 myofibril GO:0030017 sarcomere GO:0036379 myofilament GO:0043292 contractile fiber GO:0044449 contractile fiber part

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04020 Calcium signaling pathway hsa04260 Cardiac muscle contraction hsa04261 Adrenergic signaling in cardiomyocytes
Reactome	R-HSA-397014: Muscle contraction R-HSA-390522: Striated Muscle Contraction

Summary
Symbol	TNNC1
Name	troponin C type 1 (slow)
Aliases	TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location	3p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between TNNC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	TNNC1
Name	troponin C type 1 (slow)
Aliases	TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location	3p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of TNNC1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	TNNC1
Name	troponin C type 1 (slow)
Aliases	TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location	3p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of TNNC1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.438	0.419
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.291	0.741
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.963	0.193
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.597	0.436
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.55	0.649
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.651	0.627
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-1.634	0.0196
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.023	0.984
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-3.348	0.00958
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.004	0.998
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.01	0.995
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.392	0.198

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of TNNC1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	TNNC1
Name	troponin C type 1 (slow)
Aliases	TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location	3p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TNNC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	TNNC1
Name	troponin C type 1 (slow)
Aliases	TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location	3p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TNNC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TNNC1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	TNNC1
Name	troponin C type 1 (slow)
Aliases	TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location	3p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TNNC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	TNNC1
Name	troponin C type 1 (slow)
Aliases	TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location	3p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of TNNC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	TNNC1
Name	troponin C type 1 (slow)
Aliases	TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location	3p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between TNNC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	TNNC1
Name	troponin C type 1 (slow)
Aliases	TNNC; troponin C, slow; CMD1Z; CMH13; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; tr ......
Chromosomal Location	3p21.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting TNNC1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting TNNC1.

ID	Name	Drug Type	Targets	#Targets
DB00831	Trifluoperazine	Small Molecule	ADRA1A, CALY, DRD2, S100A4, TNNC1	5
DB00922	Levosimendan	Small Molecule	KCNJ11, KCNJ8, PDE3A, TNNC1	4
DB01023	Felodipine	Small Molecule	CACNA1C, CACNA1D, CACNA1H, CACNA1S, CACNA2D1, CACNA2D2, CACNB2, NR ......	12
DB01244	Bepridil	Small Molecule	ATP1A1, CACNA1A, CACNA1H, CACNA2D2, KCNH2, KCNQ1, PDE1A, PDE1B, TN ......	9
DB01373	Calcium	Small Molecule	ALPP, AOC1, ATP2C1, BMP4, CACNA1C, CAST, COMP, CP, MGP, PCDH19, PD ......	19
DB01375	Aluminium monostearate	Small Molecule	TNNC1, VDAC1, VDAC2, VDAC3	4
DB03944	5-[1-(3,4-Dimethoxy-Benzoyl)-1,2,3,4-Tetrahydro-Quinolin-6-Yl]-6-Methyl-3,6-Dihydro-[1,3,4]Thiadiazin-2-One	Small Molecule	TNNC1	1
DB04513	N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide	Small Molecule	TNNC1, TNNI3	2

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