Browse TP73

Summary
SymbolTP73
Nametumor protein p73
Aliases p53-like transcription factor; p53-related protein
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage.
Domain PF00870 P53 DNA-binding domain
PF07710 P53 tetramerisation motif
PF07647 SAM domain (Sterile alpha motif)
Function

Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

> Gene Ontology
 
Biological Process GO:0000075 cell cycle checkpoint
GO:0000077 DNA damage checkpoint
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000187 activation of MAPK activity
GO:0001655 urogenital system development
GO:0001822 kidney development
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001933 negative regulation of protein phosphorylation
GO:0006298 mismatch repair
GO:0006469 negative regulation of protein kinase activity
GO:0006839 mitochondrial transport
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007006 mitochondrial membrane organization
GO:0007050 cell cycle arrest
GO:0007093 mitotic cell cycle checkpoint
GO:0007254 JNK cascade
GO:0007346 regulation of mitotic cell cycle
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008637 apoptotic mitochondrial changes
GO:0009314 response to radiation
GO:0009411 response to UV
GO:0009416 response to light stimulus
GO:0010001 glial cell differentiation
GO:0010165 response to X-ray
GO:0010212 response to ionizing radiation
GO:0010332 response to gamma radiation
GO:0010720 positive regulation of cell development
GO:0010721 negative regulation of cell development
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0010948 negative regulation of cell cycle process
GO:0014013 regulation of gliogenesis
GO:0014015 positive regulation of gliogenesis
GO:0014706 striated muscle tissue development
GO:0014855 striated muscle cell proliferation
GO:0016202 regulation of striated muscle tissue development
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031570 DNA integrity checkpoint
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0032147 activation of protein kinase activity
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0033002 muscle cell proliferation
GO:0033673 negative regulation of kinase activity
GO:0033674 positive regulation of kinase activity
GO:0034644 cellular response to UV
GO:0035265 organ growth
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0042063 gliogenesis
GO:0042326 negative regulation of phosphorylation
GO:0042493 response to drug
GO:0042770 signal transduction in response to DNA damage
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042772 DNA damage response, signal transduction resulting in transcription
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0043410 positive regulation of MAPK cascade
GO:0043506 regulation of JUN kinase activity
GO:0043508 negative regulation of JUN kinase activity
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044770 cell cycle phase transition
GO:0044772 mitotic cell cycle phase transition
GO:0044773 mitotic DNA damage checkpoint
GO:0044774 mitotic DNA integrity checkpoint
GO:0044783 G1 DNA damage checkpoint
GO:0044819 mitotic G1/S transition checkpoint
GO:0044843 cell cycle G1/S phase transition
GO:0045665 negative regulation of neuron differentiation
GO:0045685 regulation of glial cell differentiation
GO:0045687 positive regulation of glial cell differentiation
GO:0045786 negative regulation of cell cycle
GO:0045787 positive regulation of cell cycle
GO:0045843 negative regulation of striated muscle tissue development
GO:0045860 positive regulation of protein kinase activity
GO:0045926 negative regulation of growth
GO:0045930 negative regulation of mitotic cell cycle
GO:0046328 regulation of JNK cascade
GO:0046329 negative regulation of JNK cascade
GO:0046620 regulation of organ growth
GO:0046621 negative regulation of organ growth
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048634 regulation of muscle organ development
GO:0048635 negative regulation of muscle organ development
GO:0048638 regulation of developmental growth
GO:0048640 negative regulation of developmental growth
GO:0048709 oligodendrocyte differentiation
GO:0048713 regulation of oligodendrocyte differentiation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0048738 cardiac muscle tissue development
GO:0050768 negative regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0051204 protein insertion into mitochondrial membrane
GO:0051205 protein insertion into membrane
GO:0051259 protein oligomerization
GO:0051262 protein tetramerization
GO:0051348 negative regulation of transferase activity
GO:0051402 neuron apoptotic process
GO:0051403 stress-activated MAPK cascade
GO:0051961 negative regulation of nervous system development
GO:0051962 positive regulation of nervous system development
GO:0055017 cardiac muscle tissue growth
GO:0055021 regulation of cardiac muscle tissue growth
GO:0055022 negative regulation of cardiac muscle tissue growth
GO:0055024 regulation of cardiac muscle tissue development
GO:0055026 negative regulation of cardiac muscle tissue development
GO:0060038 cardiac muscle cell proliferation
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0060044 negative regulation of cardiac muscle cell proliferation
GO:0060419 heart growth
GO:0060420 regulation of heart growth
GO:0060537 muscle tissue development
GO:0061117 negative regulation of heart growth
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070303 negative regulation of stress-activated protein kinase signaling cascade
GO:0070585 protein localization to mitochondrion
GO:0070997 neuron death
GO:0071156 regulation of cell cycle arrest
GO:0071158 positive regulation of cell cycle arrest
GO:0071214 cellular response to abiotic stimulus
GO:0071478 cellular response to radiation
GO:0071482 cellular response to light stimulus
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072001 renal system development
GO:0072331 signal transduction by p53 class mediator
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0072655 establishment of protein localization to mitochondrion
GO:0072657 protein localization to membrane
GO:0090068 positive regulation of cell cycle process
GO:0090150 establishment of protein localization to membrane
GO:0090559 regulation of membrane permeability
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097345 mitochondrial outer membrane permeabilization
GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901861 regulation of muscle tissue development
GO:1901862 negative regulation of muscle tissue development
GO:1901987 regulation of cell cycle phase transition
GO:1901988 negative regulation of cell cycle phase transition
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1901991 negative regulation of mitotic cell cycle phase transition
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902532 negative regulation of intracellular signal transduction
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death
GO:1902806 regulation of cell cycle G1/S phase transition
GO:1902807 negative regulation of cell cycle G1/S phase transition
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1904951 positive regulation of establishment of protein localization
GO:2000045 regulation of G1/S transition of mitotic cell cycle
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2001233 regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001159 core promoter proximal region DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0002039 p53 binding
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0008134 transcription factor binding
Cellular Component GO:0000785 chromatin
GO:0005667 transcription factor complex
> KEGG and Reactome Pathway
 
KEGG hsa04115 p53 signaling pathway
hsa04390 Hippo signaling pathway
hsa04722 Neurotrophin signaling pathway
Reactome R-HSA-114452: Activation of BH3-only proteins
R-HSA-139915: Activation of PUMA and translocation to mitochondria
R-HSA-109581: Apoptosis
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-109606: Intrinsic Pathway for Apoptosis
R-HSA-5357801: Programmed Cell Death
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804759: Regulation of TP53 Activity through Association with Co-factors
R-HSA-6803207: TP53 Regulates Transcription of Caspase Activators and Caspases
R-HSA-5633008: TP53 Regulates Transcription of Cell Death Genes
R-HSA-6803211: TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-6803204: TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
R-HSA-6803205: TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
R-HSA-3700989: Transcriptional Regulation by TP53
Summary
SymbolTP73
Nametumor protein p73
Aliases p53-like transcription factor; p53-related protein
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TP73 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolTP73
Nametumor protein p73
Aliases p53-like transcription factor; p53-related protein
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TP73 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTP73
Nametumor protein p73
Aliases p53-like transcription factor; p53-related protein
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TP73 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.480.156
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.220.705
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.6710.166
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.5570.274
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.4370.74
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7130.675
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1280.762
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3450.592
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0360.958
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.0350.0235
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.1050.0658
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.470.0431
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TP73 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.112.5-1.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472514.310.71
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTP73
Nametumor protein p73
Aliases p53-like transcription factor; p53-related protein
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TP73. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTP73
Nametumor protein p73
Aliases p53-like transcription factor; p53-related protein
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TP73. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TP73.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTP73
Nametumor protein p73
Aliases p53-like transcription factor; p53-related protein
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TP73. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTP73
Nametumor protein p73
Aliases p53-like transcription factor; p53-related protein
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TP73 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTP73
Nametumor protein p73
Aliases p53-like transcription factor; p53-related protein
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TP73 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTP73
Nametumor protein p73
Aliases p53-like transcription factor; p53-related protein
Chromosomal Location1p36.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TP73 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting TP73.
ID Name Drug Type Targets #Targets
DB01593ZincSmall MoleculeA1BG, A2M, AGT, AHSG, ALDOA, APCS, APLP1, APLP2, APOA1, APOA2, APO ......119