Browse TREM2

Summary
SymbolTREM2
Nametriggering receptor expressed on myeloid cells 2
Aliases TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ......
Chromosomal Location6p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform 1: Cell membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Isoform 2: Secreted ; SUBCELLULAR LOCATION: Isoform 3: Secreted
Domain PF07686 Immunoglobulin V-set domain
Function

Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines.

> Gene Ontology
 
Biological Process GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0002237 response to molecule of bacterial origin
GO:0002495 antigen processing and presentation of peptide antigen via MHC class II
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002521 leukocyte differentiation
GO:0002577 regulation of antigen processing and presentation
GO:0002579 positive regulation of antigen processing and presentation
GO:0002580 regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002582 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002583 regulation of antigen processing and presentation of peptide antigen
GO:0002585 positive regulation of antigen processing and presentation of peptide antigen
GO:0002586 regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0002588 positive regulation of antigen processing and presentation of peptide antigen via MHC class II
GO:0006909 phagocytosis
GO:0006911 phagocytosis, engulfment
GO:0006959 humoral immune response
GO:0007009 plasma membrane organization
GO:0009595 detection of biotic stimulus
GO:0010324 membrane invagination
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0019722 calcium-mediated signaling
GO:0019882 antigen processing and presentation
GO:0019932 second-messenger-mediated signaling
GO:0023035 CD40 signaling pathway
GO:0032490 detection of molecule of bacterial origin
GO:0032494 response to peptidoglycan
GO:0032496 response to lipopolysaccharide
GO:0032497 detection of lipopolysaccharide
GO:0032499 detection of peptidoglycan
GO:0038118 C-C chemokine receptor CCR7 signaling pathway
GO:0043410 positive regulation of MAPK cascade
GO:0048002 antigen processing and presentation of peptide antigen
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050848 regulation of calcium-mediated signaling
GO:0050850 positive regulation of calcium-mediated signaling
GO:0060759 regulation of response to cytokine stimulus
GO:0060760 positive regulation of response to cytokine stimulus
GO:0070098 chemokine-mediated signaling pathway
GO:0070099 regulation of chemokine-mediated signaling pathway
GO:0070101 positive regulation of chemokine-mediated signaling pathway
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070391 response to lipoteichoic acid
GO:0070392 detection of lipoteichoic acid
GO:0071216 cellular response to biotic stimulus
GO:0071219 cellular response to molecule of bacterial origin
GO:0071223 cellular response to lipoteichoic acid
GO:0071224 cellular response to peptidoglycan
GO:0071417 cellular response to organonitrogen compound
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0097028 dendritic cell differentiation
GO:0098581 detection of external biotic stimulus
GO:0099024 plasma membrane invagination
GO:1903076 regulation of protein localization to plasma membrane
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903080 regulation of C-C chemokine receptor CCR7 signaling pathway
GO:1903082 positive regulation of C-C chemokine receptor CCR7 signaling pathway
GO:1903729 regulation of plasma membrane organization
GO:1903829 positive regulation of cellular protein localization
GO:1904375 regulation of protein localization to cell periphery
GO:1904377 positive regulation of protein localization to cell periphery
GO:1990778 protein localization to cell periphery
GO:2000348 regulation of CD40 signaling pathway
GO:2000350 positive regulation of CD40 signaling pathway
Molecular Function GO:0001530 lipopolysaccharide binding
GO:0005539 glycosaminoglycan binding
GO:0042834 peptidoglycan binding
GO:0070891 lipoteichoic acid binding
GO:0097110 scaffold protein binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04380 Osteoclast differentiation
Reactome R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-1266738: Developmental Biology
R-HSA-168256: Immune System
R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-168249: Innate Immune System
R-HSA-416700: Other semaphorin interactions
R-HSA-373755: Semaphorin interactions
Summary
SymbolTREM2
Nametriggering receptor expressed on myeloid cells 2
Aliases TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ......
Chromosomal Location6p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TREM2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolTREM2
Nametriggering receptor expressed on myeloid cells 2
Aliases TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ......
Chromosomal Location6p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TREM2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTREM2
Nametriggering receptor expressed on myeloid cells 2
Aliases TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ......
Chromosomal Location6p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TREM2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1060.834
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6960.709
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3320.797
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.5210.0215
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.2630.333
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.8410.264
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2540.623
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5510.629
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0180.989
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7230.689
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6190.83
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0110.96
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TREM2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTREM2
Nametriggering receptor expressed on myeloid cells 2
Aliases TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ......
Chromosomal Location6p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TREM2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTREM2
Nametriggering receptor expressed on myeloid cells 2
Aliases TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ......
Chromosomal Location6p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TREM2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TREM2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTREM2
Nametriggering receptor expressed on myeloid cells 2
Aliases TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ......
Chromosomal Location6p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TREM2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTREM2
Nametriggering receptor expressed on myeloid cells 2
Aliases TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ......
Chromosomal Location6p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TREM2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTREM2
Nametriggering receptor expressed on myeloid cells 2
Aliases TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ......
Chromosomal Location6p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TREM2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTREM2
Nametriggering receptor expressed on myeloid cells 2
Aliases TREM-2; Trem2a; Trem2b; Trem2c; triggering receptor expressed on myeloid cells 2a; triggering receptor expre ......
Chromosomal Location6p21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TREM2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.