TISIDB

Summary
Symbol	TRIM63
Name	tripartite motif containing 63, E3 ubiquitin protein ligase
Aliases	MURF-1; IRF; SMRZ; muscle-specific RING finger protein 1; iris ring finger protein; striated muscle RING zin ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm. Nucleus Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle.
Domain	PF00643 B-box zinc finger PF13445 RING-type zinc-finger
Function	E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

> Gene Ontology [ TOP ]
Biological Process	GO:0003012 muscle system process GO:0006936 muscle contraction GO:0014732 skeletal muscle atrophy GO:0014874 response to stimulus involved in regulation of muscle adaptation GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation GO:0014888 striated muscle adaptation GO:0014889 muscle atrophy GO:0014891 striated muscle atrophy GO:0031960 response to corticosteroid GO:0043500 muscle adaptation GO:0043501 skeletal muscle adaptation GO:0043502 regulation of muscle adaptation GO:0044057 regulation of system process GO:0048545 response to steroid hormone GO:0051384 response to glucocorticoid GO:0051602 response to electrical stimulus GO:0070555 response to interleukin-1 GO:0090257 regulation of muscle system process
Molecular Function	GO:0004842 ubiquitin-protein transferase activity GO:0016874 ligase activity GO:0019787 ubiquitin-like protein transferase activity GO:0031432 titin binding
Cellular Component	GO:0005874 microtubule GO:0030016 myofibril GO:0030017 sarcomere GO:0030018 Z disc GO:0031430 M band GO:0031672 A band GO:0031674 I band GO:0043292 contractile fiber GO:0044449 contractile fiber part

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1280218: Adaptive Immune System R-HSA-983168: Antigen processing R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-168256: Immune System

Summary
Symbol	TRIM63
Name	tripartite motif containing 63, E3 ubiquitin protein ligase
Aliases	MURF-1; IRF; SMRZ; muscle-specific RING finger protein 1; iris ring finger protein; striated muscle RING zin ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between TRIM63 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	TRIM63
Name	tripartite motif containing 63, E3 ubiquitin protein ligase
Aliases	MURF-1; IRF; SMRZ; muscle-specific RING finger protein 1; iris ring finger protein; striated muscle RING zin ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of TRIM63 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	TRIM63
Name	tripartite motif containing 63, E3 ubiquitin protein ligase
Aliases	MURF-1; IRF; SMRZ; muscle-specific RING finger protein 1; iris ring finger protein; striated muscle RING zin ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of TRIM63 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.671	0.521
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	2.459	0.262
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.655	0.74
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-1.29	0.0204
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-1.003	0.338
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-1.655	0.161
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.842	0.363
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.299	0.857
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-1.548	0.406
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.293	0.621
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.209	0.796
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.119	0.677

> Mutation difference between responders and non-responders [ TOP ]
There is no record.

Summary
Symbol	TRIM63
Name	tripartite motif containing 63, E3 ubiquitin protein ligase
Aliases	MURF-1; IRF; SMRZ; muscle-specific RING finger protein 1; iris ring finger protein; striated muscle RING zin ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRIM63. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	TRIM63
Name	tripartite motif containing 63, E3 ubiquitin protein ligase
Aliases	MURF-1; IRF; SMRZ; muscle-specific RING finger protein 1; iris ring finger protein; striated muscle RING zin ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRIM63. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRIM63. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	TRIM63
Name	tripartite motif containing 63, E3 ubiquitin protein ligase
Aliases	MURF-1; IRF; SMRZ; muscle-specific RING finger protein 1; iris ring finger protein; striated muscle RING zin ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRIM63. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	TRIM63
Name	tripartite motif containing 63, E3 ubiquitin protein ligase
Aliases	MURF-1; IRF; SMRZ; muscle-specific RING finger protein 1; iris ring finger protein; striated muscle RING zin ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of TRIM63 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	TRIM63
Name	tripartite motif containing 63, E3 ubiquitin protein ligase
Aliases	MURF-1; IRF; SMRZ; muscle-specific RING finger protein 1; iris ring finger protein; striated muscle RING zin ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between TRIM63 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	TRIM63
Name	tripartite motif containing 63, E3 ubiquitin protein ligase
Aliases	MURF-1; IRF; SMRZ; muscle-specific RING finger protein 1; iris ring finger protein; striated muscle RING zin ......
Chromosomal Location	1p34-p33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting TRIM63 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse TRIM63