Browse TRPC1

Summary
SymbolTRPC1
Nametransient receptor potential cation channel, subfamily C, member 1
Aliases HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Multi-pass membrane protein.
Domain PF00520 Ion transport protein
PF08344 Transient receptor ion channel II
Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

> Gene Ontology
 
Biological Process GO:0000041 transition metal ion transport
GO:0003013 circulatory system process
GO:0003015 heart process
GO:0006582 melanin metabolic process
GO:0006816 calcium ion transport
GO:0006828 manganese ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010522 regulation of calcium ion transport into cytosol
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010959 regulation of metal ion transport
GO:0018958 phenol-containing compound metabolic process
GO:0019748 secondary metabolic process
GO:0032844 regulation of homeostatic process
GO:0032845 negative regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0034762 regulation of transmembrane transport
GO:0034764 positive regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0035637 multicellular organismal signaling
GO:0042438 melanin biosynthetic process
GO:0042440 pigment metabolic process
GO:0043270 positive regulation of ion transport
GO:0044057 regulation of system process
GO:0044550 secondary metabolite biosynthetic process
GO:0046148 pigment biosynthetic process
GO:0046189 phenol-containing compound biosynthetic process
GO:0051208 sequestering of calcium ion
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051235 maintenance of location
GO:0051238 sequestering of metal ion
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051282 regulation of sequestering of calcium ion
GO:0051283 negative regulation of sequestering of calcium ion
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051592 response to calcium ion
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
GO:0055074 calcium ion homeostasis
GO:0060047 heart contraction
GO:0060401 cytosolic calcium ion transport
GO:0060402 calcium ion transport into cytosol
GO:0061337 cardiac conduction
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0090279 regulation of calcium ion import
GO:0090280 positive regulation of calcium ion import
GO:0097553 calcium ion transmembrane import into cytosol
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
GO:1902656 calcium ion import into cytosol
GO:1903169 regulation of calcium ion transmembrane transport
GO:1903522 regulation of blood circulation
GO:1903779 regulation of cardiac conduction
GO:1904062 regulation of cation transmembrane transport
GO:1904064 positive regulation of cation transmembrane transport
GO:1904427 positive regulation of calcium ion transmembrane transport
GO:2000021 regulation of ion homeostasis
Molecular Function GO:0005216 ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0015085 calcium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0015279 store-operated calcium channel activity
GO:0022803 passive transmembrane transporter activity
GO:0022838 substrate-specific channel activity
GO:0043178 alcohol binding
GO:0046873 metal ion transmembrane transporter activity
GO:0070679 inositol 1,4,5 trisphosphate binding
GO:0072509 divalent inorganic cation transmembrane transporter activity
Cellular Component GO:0043235 receptor complex
> KEGG and Reactome Pathway
 
KEGG hsa04360 Axon guidance
hsa04724 Glutamatergic synapse
hsa04726 Serotonergic synapse
hsa04972 Pancreatic secretion
Reactome R-HSA-1280218: Adaptive Immune System
R-HSA-983695: Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-422475: Axon guidance
R-HSA-5576891: Cardiac conduction
R-HSA-1266738: Developmental Biology
R-HSA-168256: Immune System
R-HSA-983712: Ion channel transport
R-HSA-5578775: Ion homeostasis
R-HSA-397014: Muscle contraction
R-HSA-373752: Netrin-1 signaling
R-HSA-418890: Role of second messengers in netrin-1 signaling
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-2672351: Stimuli-sensing channels
R-HSA-3295583: TRP channels
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolTRPC1
Nametransient receptor potential cation channel, subfamily C, member 1
Aliases HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TRPC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolTRPC1
Nametransient receptor potential cation channel, subfamily C, member 1
Aliases HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TRPC1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTRPC1
Nametransient receptor potential cation channel, subfamily C, member 1
Aliases HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TRPC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.7140.0458
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.0510.157
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.470.447
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1890.593
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1490.932
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.6130.786
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0160.971
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2140.829
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3180.758
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2320.784
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.3780.184
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.180.191
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TRPC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTRPC1
Nametransient receptor potential cation channel, subfamily C, member 1
Aliases HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRPC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTRPC1
Nametransient receptor potential cation channel, subfamily C, member 1
Aliases HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRPC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRPC1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTRPC1
Nametransient receptor potential cation channel, subfamily C, member 1
Aliases HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRPC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTRPC1
Nametransient receptor potential cation channel, subfamily C, member 1
Aliases HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TRPC1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTRPC1
Nametransient receptor potential cation channel, subfamily C, member 1
Aliases HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TRPC1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTRPC1
Nametransient receptor potential cation channel, subfamily C, member 1
Aliases HTRP-1; capacitative calcium channel protein Trp1; transient receptor potential canonical 1; transient recep ......
Chromosomal Location3q23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TRPC1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.