Browse TRPC6

Summary
SymbolTRPC6
Nametransient receptor potential cation channel, subfamily C, member 6
Aliases TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ......
Chromosomal Location11q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein
Domain PF12796 Ankyrin repeats (3 copies)
PF00520 Ion transport protein
PF08344 Transient receptor ion channel II
Function

Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion.

> Gene Ontology
 
Biological Process GO:0000041 transition metal ion transport
GO:0000302 response to reactive oxygen species
GO:0001666 response to hypoxia
GO:0006816 calcium ion transport
GO:0006828 manganese ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006979 response to oxidative stress
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007338 single fertilization
GO:0007568 aging
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0009566 fertilization
GO:0010035 response to inorganic substance
GO:0010720 positive regulation of cell development
GO:0010721 negative regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010771 negative regulation of cell morphogenesis involved in differentiation
GO:0010799 regulation of peptidyl-threonine phosphorylation
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010959 regulation of metal ion transport
GO:0010975 regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0016358 dendrite development
GO:0018107 peptidyl-threonine phosphorylation
GO:0018210 peptidyl-threonine modification
GO:0022604 regulation of cell morphogenesis
GO:0022898 regulation of transmembrane transporter activity
GO:0030168 platelet activation
GO:0031345 negative regulation of cell projection organization
GO:0032409 regulation of transporter activity
GO:0032411 positive regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032414 positive regulation of ion transmembrane transporter activity
GO:0034599 cellular response to oxidative stress
GO:0034614 cellular response to reactive oxygen species
GO:0034762 regulation of transmembrane transport
GO:0034764 positive regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0036293 response to decreased oxygen levels
GO:0036294 cellular response to decreased oxygen levels
GO:0042542 response to hydrogen peroxide
GO:0043270 positive regulation of ion transport
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048813 dendrite morphogenesis
GO:0048814 regulation of dendrite morphogenesis
GO:0050768 negative regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0050773 regulation of dendrite development
GO:0050774 negative regulation of dendrite morphogenesis
GO:0050817 coagulation
GO:0050878 regulation of body fluid levels
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
GO:0051961 negative regulation of nervous system development
GO:0051962 positive regulation of nervous system development
GO:0055074 calcium ion homeostasis
GO:0070301 cellular response to hydrogen peroxide
GO:0070482 response to oxygen levels
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0071453 cellular response to oxygen levels
GO:0071456 cellular response to hypoxia
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:2000171 negative regulation of dendrite development
Molecular Function GO:0003779 actin binding
GO:0005216 ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0015085 calcium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0015279 store-operated calcium channel activity
GO:0022803 passive transmembrane transporter activity
GO:0022838 substrate-specific channel activity
GO:0030276 clathrin binding
GO:0042805 actinin binding
GO:0043178 alcohol binding
GO:0046873 metal ion transmembrane transporter activity
GO:0051117 ATPase binding
GO:0070679 inositol 1,4,5 trisphosphate binding
GO:0072509 divalent inorganic cation transmembrane transporter activity
Cellular Component GO:0036056 filtration diaphragm
GO:0036057 slit diaphragm
> KEGG and Reactome Pathway
 
KEGG hsa04022 cGMP-PKG signaling pathway
hsa04360 Axon guidance
Reactome R-HSA-422475: Axon guidance
R-HSA-1266738: Developmental Biology
R-HSA-114508: Effects of PIP2 hydrolysis
R-HSA-139853: Elevation of cytosolic Ca2+ levels
R-HSA-416476: G alpha (q) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-109582: Hemostasis
R-HSA-983712: Ion channel transport
R-HSA-373752: Netrin-1 signaling
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-418360: Platelet calcium homeostasis
R-HSA-418346: Platelet homeostasis
R-HSA-418890: Role of second messengers in netrin-1 signaling
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-2672351: Stimuli-sensing channels
R-HSA-3295583: TRP channels
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolTRPC6
Nametransient receptor potential cation channel, subfamily C, member 6
Aliases TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ......
Chromosomal Location11q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TRPC6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolTRPC6
Nametransient receptor potential cation channel, subfamily C, member 6
Aliases TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ......
Chromosomal Location11q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TRPC6 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTRPC6
Nametransient receptor potential cation channel, subfamily C, member 6
Aliases TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ......
Chromosomal Location11q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TRPC6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.9170.00727
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.9110.000208
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2030.702
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.7330.0649
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.0780.49
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3070.858
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0060.988
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1290.849
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1190.865
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4010.589
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2760.172
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1980.142
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TRPC6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.85.59.30.206
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.85.19.70.199
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.67.4-4.80.565
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221307.7-7.70.371
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTRPC6
Nametransient receptor potential cation channel, subfamily C, member 6
Aliases TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ......
Chromosomal Location11q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRPC6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTRPC6
Nametransient receptor potential cation channel, subfamily C, member 6
Aliases TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ......
Chromosomal Location11q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRPC6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRPC6.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTRPC6
Nametransient receptor potential cation channel, subfamily C, member 6
Aliases TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ......
Chromosomal Location11q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRPC6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTRPC6
Nametransient receptor potential cation channel, subfamily C, member 6
Aliases TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ......
Chromosomal Location11q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TRPC6 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTRPC6
Nametransient receptor potential cation channel, subfamily C, member 6
Aliases TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ......
Chromosomal Location11q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TRPC6 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTRPC6
Nametransient receptor potential cation channel, subfamily C, member 6
Aliases TRP6; FSGS2; focal segmental glomerulosclerosis 2; TRP-6; transient receptor protein 6; Short transient rece ......
Chromosomal Location11q22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TRPC6 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.