TISIDB

Summary
Symbol	TRPV1
Name	transient receptor potential cation channel, subfamily V, member 1
Aliases	vanilloid receptor subtype 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; transient receptor poten ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell junction, synapse, postsynaptic cell membrane Multi-pass membrane protein Cell projection, dendritic spine membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines.
Domain	PF12796 Ankyrin repeats (3 copies) PF00520 Ion transport protein
Function	Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.

> Gene Ontology [ TOP ]
Biological Process	GO:0001659 temperature homeostasis GO:0001660 fever generation GO:0001696 gastric acid secretion GO:0001774 microglial cell activation GO:0002021 response to dietary excess GO:0002024 diet induced thermogenesis GO:0002274 myeloid leukocyte activation GO:0002526 acute inflammatory response GO:0002790 peptide secretion GO:0003012 muscle system process GO:0003014 renal system process GO:0006809 nitric oxide biosynthetic process GO:0006816 calcium ion transport GO:0006820 anion transport GO:0006835 dicarboxylic acid transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006936 muscle contraction GO:0006939 smooth muscle contraction GO:0006953 acute-phase response GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007586 digestion GO:0007588 excretion GO:0007635 chemosensory behavior GO:0009266 response to temperature stimulus GO:0009268 response to pH GO:0009408 response to heat GO:0009581 detection of external stimulus GO:0009582 detection of abiotic stimulus GO:0009991 response to extracellular stimulus GO:0010447 response to acidic pH GO:0010721 negative regulation of cell development GO:0014047 glutamate secretion GO:0014074 response to purine-containing compound GO:0014832 urinary bladder smooth muscle contraction GO:0014848 urinary tract smooth muscle contraction GO:0015711 organic anion transport GO:0015833 peptide transport GO:0016048 detection of temperature stimulus GO:0019233 sensory perception of pain GO:0022600 digestive system process GO:0031649 heat generation GO:0031667 response to nutrient levels GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0033198 response to ATP GO:0033555 multicellular organismal response to stress GO:0034605 cellular response to heat GO:0034612 response to tumor necrosis factor GO:0042116 macrophage activation GO:0042886 amide transport GO:0043279 response to alkaloid GO:0043434 response to peptide hormone GO:0044057 regulation of system process GO:0044058 regulation of digestive system process GO:0044236 multicellular organism metabolic process GO:0044708 single-organism behavior GO:0045428 regulation of nitric oxide biosynthetic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0046209 nitric oxide metabolic process GO:0046683 response to organophosphorus GO:0046717 acid secretion GO:0046942 carboxylic acid transport GO:0048265 response to pain GO:0048266 behavioral response to pain GO:0048871 multicellular organismal homeostasis GO:0050907 detection of chemical stimulus involved in sensory perception GO:0050951 sensory perception of temperature stimulus GO:0050954 sensory perception of mechanical stimulus GO:0050955 thermoception GO:0050960 detection of temperature stimulus involved in thermoception GO:0050961 detection of temperature stimulus involved in sensory perception GO:0050965 detection of temperature stimulus involved in sensory perception of pain GO:0050968 detection of chemical stimulus involved in sensory perception of pain GO:0051047 positive regulation of secretion GO:0051208 sequestering of calcium ion GO:0051209 release of sequestered calcium ion into cytosol GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051262 protein tetramerization GO:0051282 regulation of sequestering of calcium ion GO:0051283 negative regulation of sequestering of calcium ion GO:0051289 protein homotetramerization GO:0051480 regulation of cytosolic calcium ion concentration GO:0055074 calcium ion homeostasis GO:0060073 micturition GO:0060083 smooth muscle contraction involved in micturition GO:0060401 cytosolic calcium ion transport GO:0060402 calcium ion transport into cytosol GO:0060453 regulation of gastric acid secretion GO:0060454 positive regulation of gastric acid secretion GO:0060456 positive regulation of digestive system process GO:0060856 establishment of blood-brain barrier GO:0070509 calcium ion import GO:0070588 calcium ion transmembrane transport GO:0070838 divalent metal ion transport GO:0071214 cellular response to abiotic stimulus GO:0071312 cellular response to alkaloid GO:0071318 cellular response to ATP GO:0071356 cellular response to tumor necrosis factor GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071467 cellular response to pH GO:0071468 cellular response to acidic pH GO:0071502 cellular response to temperature stimulus GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0072593 reactive oxygen species metabolic process GO:0090210 regulation of establishment of blood-brain barrier GO:0090212 negative regulation of establishment of blood-brain barrier GO:0097553 calcium ion transmembrane import into cytosol GO:0098657 import into cell GO:0098659 inorganic cation import into cell GO:0099587 inorganic ion import into cell GO:1901594 response to capsazepine GO:1901652 response to peptide GO:1902656 calcium ion import into cytosol GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1904407 positive regulation of nitric oxide metabolic process GO:1990035 calcium ion import into cell GO:1990089 response to nerve growth factor GO:1990090 cellular response to nerve growth factor stimulus GO:1990845 adaptive thermogenesis GO:2000021 regulation of ion homeostasis GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2001057 reactive nitrogen species metabolic process
Molecular Function	GO:0005216 ion channel activity GO:0005217 intracellular ligand-gated ion channel activity GO:0005230 extracellular ligand-gated ion channel activity GO:0005231 excitatory extracellular ligand-gated ion channel activity GO:0005261 cation channel activity GO:0005262 calcium channel activity GO:0005516 calmodulin binding GO:0005543 phospholipid binding GO:0015085 calcium ion transmembrane transporter activity GO:0015267 channel activity GO:0015276 ligand-gated ion channel activity GO:0015278 calcium-release channel activity GO:0016247 channel regulator activity GO:0017081 chloride channel regulator activity GO:0022803 passive transmembrane transporter activity GO:0022834 ligand-gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity GO:0035091 phosphatidylinositol binding GO:0046873 metal ion transmembrane transporter activity GO:0051219 phosphoprotein binding GO:0072509 divalent inorganic cation transmembrane transporter activity GO:0097603 temperature-gated ion channel activity GO:0099604 ligand-gated calcium channel activity
Cellular Component	GO:0009897 external side of plasma membrane GO:0030425 dendrite GO:0031252 cell leading edge GO:0031253 cell projection membrane GO:0031256 leading edge membrane GO:0032589 neuron projection membrane GO:0032590 dendrite membrane GO:0032591 dendritic spine membrane GO:0043025 neuronal cell body GO:0044297 cell body GO:0045211 postsynaptic membrane GO:0097060 synaptic membrane GO:0098552 side of membrane GO:0098794 postsynapse

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04080 Neuroactive ligand-receptor interaction hsa04750 Inflammatory mediator regulation of TRP channels
Reactome	R-HSA-983712: Ion channel transport R-HSA-2672351: Stimuli-sensing channels R-HSA-3295583: TRP channels R-HSA-382551: Transmembrane transport of small molecules

Summary
Symbol	TRPV1
Name	transient receptor potential cation channel, subfamily V, member 1
Aliases	vanilloid receptor subtype 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; transient receptor poten ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between TRPV1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between TRPV1 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
29580868	Melanoma	Promote immunity	Altogether, our study demonstrates that TRPV1 is a potential tumor suppressor in melanoma.

Summary
Symbol	TRPV1
Name	transient receptor potential cation channel, subfamily V, member 1
Aliases	vanilloid receptor subtype 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; transient receptor poten ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of TRPV1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	TRPV1
Name	transient receptor potential cation channel, subfamily V, member 1
Aliases	vanilloid receptor subtype 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; transient receptor poten ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of TRPV1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.243	0.287
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.868	0.075
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.211	0.623
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.629	0.0828
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.247	0.879
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	1.12	0.616
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.282	0.329
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.715	0.321
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.309	0.738
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.487	0.377
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.251	0.0828
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.065	0.523

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of TRPV1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	1.4	-1.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	1.7	-1.7	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	9.1	0	9.1	0.458
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	20	0	20	0.294

Summary
Symbol	TRPV1
Name	transient receptor potential cation channel, subfamily V, member 1
Aliases	vanilloid receptor subtype 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; transient receptor poten ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TRPV1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	TRPV1
Name	transient receptor potential cation channel, subfamily V, member 1
Aliases	vanilloid receptor subtype 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; transient receptor poten ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TRPV1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TRPV1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	TRPV1
Name	transient receptor potential cation channel, subfamily V, member 1
Aliases	vanilloid receptor subtype 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; transient receptor poten ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TRPV1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	TRPV1
Name	transient receptor potential cation channel, subfamily V, member 1
Aliases	vanilloid receptor subtype 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; transient receptor poten ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of TRPV1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	TRPV1
Name	transient receptor potential cation channel, subfamily V, member 1
Aliases	vanilloid receptor subtype 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; transient receptor poten ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between TRPV1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	TRPV1
Name	transient receptor potential cation channel, subfamily V, member 1
Aliases	vanilloid receptor subtype 1; OTRPC1; capsaicin receptor; osm-9-like TRP channel 1; transient receptor poten ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting TRPV1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting TRPV1.

ID	Name	Drug Type	Targets	#Targets
DB00132	Alpha-Linolenic Acid	Small Molecule	ELOVL4, FADS1, FADS2, NR1H4, PPARA, PPARD, PPARG, RXRA, SLC8A1, TR ......	10
DB00159	Icosapent	Small Molecule	ACSL3, ACSL4, FADS1, FFAR1, PPARA, PPARD, PPARG, PTGS1, PTGS2, SLC ......	11
DB00168	Aspartame	Small Molecule	TAS1R2, TAS1R3, TRPV1	3
DB00316	Acetaminophen	Small Molecule	FAAH, GSTP1, PTGS1, PTGS2, TRPV1	5
DB02955	Ricinoleic Acid	Small Molecule	CNR1, CNR2, TRPV1	3
DB06515	Resiniferatoxin	Small Molecule	TRPV1	1
DB06774	Capsaicin	Small Molecule	PHB2, TRPV1	2
DB09061	Cannabidiol	Small Molecule	CACNA1G, CACNA1H, CACNA1I, CHRNA7, CNR1, CNR2, GLRA1, GLRA1, GLRA3 ......	25
DB09120	Zucapsaicin	Small Molecule	TRPV1	1
DB09288	Propacetamol	Small Molecule	CNR1, PTGS1, PTGS2, TRPV1	4
DB11131	Capsicum oleoresin	Biotech	TRPV1	1

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