Browse TUBGCP6

Summary
SymbolTUBGCP6
Nametubulin, gamma complex associated protein 6
Aliases GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR
Chromosomal Location22q13.31-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Domain PF04130 Spc97 / Spc98 family
Function

Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0007020 microtubule nucleation
GO:0007051 spindle organization
GO:0007067 mitotic nuclear division
GO:0007098 centrosome cycle
GO:0007126 meiotic nuclear division
GO:0031023 microtubule organizing center organization
GO:0031109 microtubule polymerization or depolymerization
GO:0031122 cytoplasmic microtubule organization
GO:0046785 microtubule polymerization
GO:0051225 spindle assembly
GO:0051258 protein polymerization
GO:0051297 centrosome organization
GO:0051298 centrosome duplication
GO:0051321 meiotic cell cycle
GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center
GO:0051418 microtubule nucleation by microtubule organizing center
GO:0090307 mitotic spindle assembly
GO:1902850 microtubule cytoskeleton organization involved in mitosis
GO:1903046 meiotic cell cycle process
Molecular Function GO:0005200 structural constituent of cytoskeleton
GO:0008017 microtubule binding
GO:0015631 tubulin binding
GO:0043015 gamma-tubulin binding
GO:0051011 microtubule minus-end binding
Cellular Component GO:0000923 equatorial microtubule organizing center
GO:0000930 gamma-tubulin complex
GO:0000931 gamma-tubulin large complex
GO:0005813 centrosome
GO:0005874 microtubule
GO:0008274 gamma-tubulin ring complex
GO:0032153 cell division site
GO:0032155 cell division site part
GO:0044450 microtubule organizing center part
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-380287: Centrosome maturation
R-HSA-69275: G2/M Transition
R-HSA-453274: Mitotic G2-G2/M phases
R-HSA-380320: Recruitment of NuMA to mitotic centrosomes
R-HSA-380270: Recruitment of mitotic centrosome proteins and complexes
Summary
SymbolTUBGCP6
Nametubulin, gamma complex associated protein 6
Aliases GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR
Chromosomal Location22q13.31-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TUBGCP6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolTUBGCP6
Nametubulin, gamma complex associated protein 6
Aliases GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR
Chromosomal Location22q13.31-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TUBGCP6 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTUBGCP6
Nametubulin, gamma complex associated protein 6
Aliases GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR
Chromosomal Location22q13.31-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TUBGCP6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0650.78
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.190.893
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0190.987
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2120.533
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.230.935
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1910.958
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1540.656
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4080.786
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0920.955
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0620.964
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.9680.582
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.160.0138
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of TUBGCP6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.811.8-70.577
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.718.2-10.50.576
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91633.3033.30.0365
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59400400.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.33.71.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolTUBGCP6
Nametubulin, gamma complex associated protein 6
Aliases GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR
Chromosomal Location22q13.31-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TUBGCP6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTUBGCP6
Nametubulin, gamma complex associated protein 6
Aliases GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR
Chromosomal Location22q13.31-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TUBGCP6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TUBGCP6.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTUBGCP6
Nametubulin, gamma complex associated protein 6
Aliases GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR
Chromosomal Location22q13.31-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TUBGCP6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTUBGCP6
Nametubulin, gamma complex associated protein 6
Aliases GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR
Chromosomal Location22q13.31-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TUBGCP6 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTUBGCP6
Nametubulin, gamma complex associated protein 6
Aliases GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR
Chromosomal Location22q13.31-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TUBGCP6 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTUBGCP6
Nametubulin, gamma complex associated protein 6
Aliases GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR
Chromosomal Location22q13.31-q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TUBGCP6 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.