Summary | |
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Symbol | TUBGCP6 |
Name | tubulin, gamma complex associated protein 6 |
Aliases | GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR |
Chromosomal Location | 22q13.31-q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome |
Domain |
PF04130 Spc97 / Spc98 family |
Function |
Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome. |
Biological Process |
GO:0000226 microtubule cytoskeleton organization GO:0007020 microtubule nucleation GO:0007051 spindle organization GO:0007067 mitotic nuclear division GO:0007098 centrosome cycle GO:0007126 meiotic nuclear division GO:0031023 microtubule organizing center organization GO:0031109 microtubule polymerization or depolymerization GO:0031122 cytoplasmic microtubule organization GO:0046785 microtubule polymerization GO:0051225 spindle assembly GO:0051258 protein polymerization GO:0051297 centrosome organization GO:0051298 centrosome duplication GO:0051321 meiotic cell cycle GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center GO:0051418 microtubule nucleation by microtubule organizing center GO:0090307 mitotic spindle assembly GO:1902850 microtubule cytoskeleton organization involved in mitosis GO:1903046 meiotic cell cycle process |
Molecular Function |
GO:0005200 structural constituent of cytoskeleton GO:0008017 microtubule binding GO:0015631 tubulin binding GO:0043015 gamma-tubulin binding GO:0051011 microtubule minus-end binding |
Cellular Component |
GO:0000923 equatorial microtubule organizing center GO:0000930 gamma-tubulin complex GO:0000931 gamma-tubulin large complex GO:0005813 centrosome GO:0005874 microtubule GO:0008274 gamma-tubulin ring complex GO:0032153 cell division site GO:0032155 cell division site part GO:0044450 microtubule organizing center part |
KEGG | - |
Reactome |
R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-380287: Centrosome maturation R-HSA-69275: G2/M Transition R-HSA-453274: Mitotic G2-G2/M phases R-HSA-380320: Recruitment of NuMA to mitotic centrosomes R-HSA-380270: Recruitment of mitotic centrosome proteins and complexes |
Summary | |
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Symbol | TUBGCP6 |
Name | tubulin, gamma complex associated protein 6 |
Aliases | GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR |
Chromosomal Location | 22q13.31-q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between TUBGCP6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | TUBGCP6 |
Name | tubulin, gamma complex associated protein 6 |
Aliases | GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR |
Chromosomal Location | 22q13.31-q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of TUBGCP6 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | TUBGCP6 |
Name | tubulin, gamma complex associated protein 6 |
Aliases | GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR |
Chromosomal Location | 22q13.31-q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of TUBGCP6 in various data sets.
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Points in the above scatter plot represent the mutation difference of TUBGCP6 in various data sets.
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Summary | |
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Symbol | TUBGCP6 |
Name | tubulin, gamma complex associated protein 6 |
Aliases | GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR |
Chromosomal Location | 22q13.31-q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TUBGCP6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | TUBGCP6 |
Name | tubulin, gamma complex associated protein 6 |
Aliases | GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR |
Chromosomal Location | 22q13.31-q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TUBGCP6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TUBGCP6. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | TUBGCP6 |
Name | tubulin, gamma complex associated protein 6 |
Aliases | GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR |
Chromosomal Location | 22q13.31-q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TUBGCP6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | TUBGCP6 |
Name | tubulin, gamma complex associated protein 6 |
Aliases | GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR |
Chromosomal Location | 22q13.31-q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of TUBGCP6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | TUBGCP6 |
Name | tubulin, gamma complex associated protein 6 |
Aliases | GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR |
Chromosomal Location | 22q13.31-q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between TUBGCP6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | TUBGCP6 |
Name | tubulin, gamma complex associated protein 6 |
Aliases | GCP6; KIAA1669; DJ402G11.6; gamma-tubulin complex component 6; GCP-6; MCCRP; MCCRP1; MCPHCR |
Chromosomal Location | 22q13.31-q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting TUBGCP6 collected from DrugBank database. |
There is no record. |