Browse TXN

Summary
SymbolTXN
Namethioredoxin
Aliases TRDX; ATL-derived factor; TXN delta 3; surface-associated sulphydryl protein; thioredoxin delta 3
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm Secreted Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted by a leaderless secretory pathway (PubMed:1332947).
Domain PF00085 Thioredoxin
Function

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.; FUNCTION: ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).

> Gene Ontology
 
Biological Process GO:0000060 protein import into nucleus, translocation
GO:0000103 sulfate assimilation
GO:0000302 response to reactive oxygen species
GO:0006457 protein folding
GO:0006606 protein import into nucleus
GO:0006611 protein export from nucleus
GO:0006662 glycerol ether metabolic process
GO:0006790 sulfur compound metabolic process
GO:0006913 nucleocytoplasmic transport
GO:0006979 response to oxidative stress
GO:0009314 response to radiation
GO:0010035 response to inorganic substance
GO:0015949 nucleobase-containing small molecule interconversion
GO:0017038 protein import
GO:0018105 peptidyl-serine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018904 ether metabolic process
GO:0030091 protein repair
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032386 regulation of intracellular transport
GO:0032387 negative regulation of intracellular transport
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033157 regulation of intracellular protein transport
GO:0033158 regulation of protein import into nucleus, translocation
GO:0033674 positive regulation of kinase activity
GO:0034504 protein localization to nucleus
GO:0034599 cellular response to oxidative stress
GO:0034614 cellular response to reactive oxygen species
GO:0036473 cell death in response to oxidative stress
GO:0036474 cell death in response to hydrogen peroxide
GO:0042306 regulation of protein import into nucleus
GO:0042542 response to hydrogen peroxide
GO:0043388 positive regulation of DNA binding
GO:0043491 protein kinase B signaling
GO:0044744 protein targeting to nucleus
GO:0045454 cell redox homeostasis
GO:0045860 positive regulation of protein kinase activity
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046823 negative regulation of nucleocytoplasmic transport
GO:0046825 regulation of protein export from nucleus
GO:0046826 negative regulation of protein export from nucleus
GO:0051051 negative regulation of transport
GO:0051098 regulation of binding
GO:0051099 positive regulation of binding
GO:0051101 regulation of DNA binding
GO:0051168 nuclear export
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051224 negative regulation of protein transport
GO:0051896 regulation of protein kinase B signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0070301 cellular response to hydrogen peroxide
GO:0090317 negative regulation of intracellular protein transport
GO:1900180 regulation of protein localization to nucleus
GO:1900407 regulation of cellular response to oxidative stress
GO:1900408 negative regulation of cellular response to oxidative stress
GO:1901031 regulation of response to reactive oxygen species
GO:1901032 negative regulation of response to reactive oxygen species
GO:1902593 single-organism nuclear import
GO:1902882 regulation of response to oxidative stress
GO:1902883 negative regulation of response to oxidative stress
GO:1903201 regulation of oxidative stress-induced cell death
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1903205 regulation of hydrogen peroxide-induced cell death
GO:1903206 negative regulation of hydrogen peroxide-induced cell death
GO:1903533 regulation of protein targeting
GO:1903828 negative regulation of cellular protein localization
GO:1904589 regulation of protein import
GO:1904950 negative regulation of establishment of protein localization
Molecular Function GO:0015035 protein disulfide oxidoreductase activity
GO:0015036 disulfide oxidoreductase activity
GO:0015037 peptide disulfide oxidoreductase activity
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04621 NOD-like receptor signaling pathway
Reactome R-HSA-2559583: Cellular Senescence
R-HSA-2262752: Cellular responses to stress
R-HSA-3299685: Detoxification of Reactive Oxygen Species
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-168256: Immune System
R-HSA-622312: Inflammasomes
R-HSA-168249: Innate Immune System
R-HSA-1430728: Metabolism
R-HSA-15869: Metabolism of nucleotides
R-HSA-392499: Metabolism of proteins
R-HSA-168643: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-2559580: Oxidative Stress Induced Senescence
R-HSA-5676934: Protein repair
R-HSA-499943: Synthesis and interconversion of nucleotide di- and triphosphates
R-HSA-5628897: TP53 Regulates Metabolic Genes
R-HSA-844456: The NLRP3 inflammasome
R-HSA-3700989: Transcriptional Regulation by TP53
Summary
SymbolTXN
Namethioredoxin
Aliases TRDX; ATL-derived factor; TXN delta 3; surface-associated sulphydryl protein; thioredoxin delta 3
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between TXN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between TXN and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29655625colon carcinomaPromote immunityFirst, the immunogenicity of the previously employed bacterial thioredoxin (TRX) was reduced by using a truncated from (TRXtr).
Summary
SymbolTXN
Namethioredoxin
Aliases TRDX; ATL-derived factor; TXN delta 3; surface-associated sulphydryl protein; thioredoxin delta 3
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of TXN in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolTXN
Namethioredoxin
Aliases TRDX; ATL-derived factor; TXN delta 3; surface-associated sulphydryl protein; thioredoxin delta 3
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of TXN in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0980.735
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1110.976
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0880.974
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.180.789
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5660.697
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.1340.571
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0110.982
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.230.908
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1970.93
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1930.938
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.1370.971
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0370.736
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolTXN
Namethioredoxin
Aliases TRDX; ATL-derived factor; TXN delta 3; surface-associated sulphydryl protein; thioredoxin delta 3
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of TXN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolTXN
Namethioredoxin
Aliases TRDX; ATL-derived factor; TXN delta 3; surface-associated sulphydryl protein; thioredoxin delta 3
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of TXN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by TXN.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolTXN
Namethioredoxin
Aliases TRDX; ATL-derived factor; TXN delta 3; surface-associated sulphydryl protein; thioredoxin delta 3
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of TXN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolTXN
Namethioredoxin
Aliases TRDX; ATL-derived factor; TXN delta 3; surface-associated sulphydryl protein; thioredoxin delta 3
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of TXN expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolTXN
Namethioredoxin
Aliases TRDX; ATL-derived factor; TXN delta 3; surface-associated sulphydryl protein; thioredoxin delta 3
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between TXN and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolTXN
Namethioredoxin
Aliases TRDX; ATL-derived factor; TXN delta 3; surface-associated sulphydryl protein; thioredoxin delta 3
Chromosomal Location9q31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting TXN collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting TXN.
ID Name Drug Type Targets #Targets
DB12695Phenethyl IsothiocyanateSmall MoleculeACTA2, ACTB, ATP5B, ATP5I, ATP5L, CYB5B, DIABLO, FBXO41, HNRNPF, H ......45