TISIDB

Summary
Symbol	UBA6
Name	ubiquitin-like modifier activating enzyme 6
Aliases	FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ......
Chromosomal Location	4q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	-
Domain	PF16191 Ubiquitin-activating enzyme E1 four-helix bundle PF16190 Ubiquitin-activating enzyme E1 FCCH domain PF09358 Ubiquitin fold domain PF00899 ThiF family PF10585 Ubiquitin-activating enzyme active site
Function	Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility.

> Gene Ontology [ TOP ]
Biological Process	GO:0007611 learning or memory GO:0007612 learning GO:0007626 locomotory behavior GO:0016358 dendrite development GO:0021537 telencephalon development GO:0021543 pallium development GO:0021761 limbic system development GO:0021764 amygdala development GO:0021766 hippocampus development GO:0030900 forebrain development GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0044708 single-organism behavior GO:0050890 cognition GO:0060996 dendritic spine development
Molecular Function	GO:0004839 ubiquitin activating enzyme activity GO:0008641 small protein activating enzyme activity GO:0016874 ligase activity GO:0016877 ligase activity, forming carbon-sulfur bonds GO:0019780 FAT10 activating enzyme activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04120 Ubiquitin mediated proteolysis
Reactome	R-HSA-1280218: Adaptive Immune System R-HSA-983168: Antigen processing R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-168256: Immune System R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-8852135: Protein ubiquitination R-HSA-8866652: Synthesis of active ubiquitin

Summary
Symbol	UBA6
Name	ubiquitin-like modifier activating enzyme 6
Aliases	FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ......
Chromosomal Location	4q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between UBA6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	UBA6
Name	ubiquitin-like modifier activating enzyme 6
Aliases	FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ......
Chromosomal Location	4q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of UBA6 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	logFC: -2.35; FDR: 0.04630	Resistant to T cell-mediated killing
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	logFC: -2.66; FDR: 0.02150	Resistant to T cell-mediated killing
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	UBA6
Name	ubiquitin-like modifier activating enzyme 6
Aliases	FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ......
Chromosomal Location	4q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of UBA6 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.096	0.776
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.135	0.924
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.272	0.773
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.178	0.658
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.48	0.807
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.205	0.935
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.096	0.827
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.113	0.948
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.017	0.993
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.553	0.624
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.113	0.943
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.03	0.688

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of UBA6 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	5.9	-5.9	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	33.3	-33.3	0.231
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	5.5	1.9	0.66
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	7.1	-7.1	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	5.1	2.3	0.647
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	25	0	25	0.364
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	5.3	0	5.3	0.507
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	9.1	0	9.1	0.519
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	UBA6
Name	ubiquitin-like modifier activating enzyme 6
Aliases	FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ......
Chromosomal Location	4q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UBA6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	UBA6
Name	ubiquitin-like modifier activating enzyme 6
Aliases	FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ......
Chromosomal Location	4q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UBA6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UBA6. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	UBA6
Name	ubiquitin-like modifier activating enzyme 6
Aliases	FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ......
Chromosomal Location	4q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UBA6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	UBA6
Name	ubiquitin-like modifier activating enzyme 6
Aliases	FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ......
Chromosomal Location	4q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of UBA6 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	UBA6
Name	ubiquitin-like modifier activating enzyme 6
Aliases	FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ......
Chromosomal Location	4q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between UBA6 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	UBA6
Name	ubiquitin-like modifier activating enzyme 6
Aliases	FLJ10808; UBA6, ubiquitin-activating enzyme E1; UBE1L2; ubiquitin-activating enzyme E1-like 2; E1-L2; MOP-4; ......
Chromosomal Location	4q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting UBA6 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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