Browse UCKL1

Summary
SymbolUCKL1
Nameuridine-cytidine kinase 1-like 1
Aliases FLJ20517; URKL1; uridine kinase-like 1; UCK1L; UCK1-LIKE; Uridine-cytidine kinase-like 1
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Note=EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location.
Domain PF00485 Phosphoribulokinase / Uridine kinase family
Function

May contribute to UTP accumulation needed for blast transformation and proliferation.

> Gene Ontology
 
Biological Process GO:0006206 pyrimidine nucleobase metabolic process
GO:0006213 pyrimidine nucleoside metabolic process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0008655 pyrimidine-containing compound salvage
GO:0009112 nucleobase metabolic process
GO:0009116 nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009123 nucleoside monophosphate metabolic process
GO:0009124 nucleoside monophosphate biosynthetic process
GO:0009129 pyrimidine nucleoside monophosphate metabolic process
GO:0009130 pyrimidine nucleoside monophosphate biosynthetic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0009147 pyrimidine nucleoside triphosphate metabolic process
GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process
GO:0009156 ribonucleoside monophosphate biosynthetic process
GO:0009161 ribonucleoside monophosphate metabolic process
GO:0009163 nucleoside biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009173 pyrimidine ribonucleoside monophosphate metabolic process
GO:0009174 pyrimidine ribonucleoside monophosphate biosynthetic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009201 ribonucleoside triphosphate biosynthetic process
GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process
GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process
GO:0009218 pyrimidine ribonucleotide metabolic process
GO:0009220 pyrimidine ribonucleotide biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0010138 pyrimidine ribonucleotide salvage
GO:0032262 pyrimidine nucleotide salvage
GO:0042455 ribonucleoside biosynthetic process
GO:0043094 cellular metabolic compound salvage
GO:0043097 pyrimidine nucleoside salvage
GO:0043173 nucleotide salvage
GO:0043174 nucleoside salvage
GO:0044206 UMP salvage
GO:0044211 CTP salvage
GO:0046036 CTP metabolic process
GO:0046049 UMP metabolic process
GO:0046131 pyrimidine ribonucleoside metabolic process
GO:0046132 pyrimidine ribonucleoside biosynthetic process
GO:0046134 pyrimidine nucleoside biosynthetic process
GO:0046390 ribose phosphate biosynthetic process
GO:0072527 pyrimidine-containing compound metabolic process
GO:0072528 pyrimidine-containing compound biosynthetic process
GO:1901293 nucleoside phosphate biosynthetic process
GO:1901657 glycosyl compound metabolic process
GO:1901659 glycosyl compound biosynthetic process
Molecular Function GO:0004849 uridine kinase activity
GO:0019205 nucleobase-containing compound kinase activity
GO:0019206 nucleoside kinase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00240 Pyrimidine metabolism
hsa00983 Drug metabolism - other enzymes
hsa01100 Metabolic pathways
Reactome -
Summary
SymbolUCKL1
Nameuridine-cytidine kinase 1-like 1
Aliases FLJ20517; URKL1; uridine kinase-like 1; UCK1L; UCK1-LIKE; Uridine-cytidine kinase-like 1
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between UCKL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolUCKL1
Nameuridine-cytidine kinase 1-like 1
Aliases FLJ20517; URKL1; uridine kinase-like 1; UCK1L; UCK1-LIKE; Uridine-cytidine kinase-like 1
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of UCKL1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.54 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolUCKL1
Nameuridine-cytidine kinase 1-like 1
Aliases FLJ20517; URKL1; uridine kinase-like 1; UCK1L; UCK1-LIKE; Uridine-cytidine kinase-like 1
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of UCKL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2760.281
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3690.858
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2110.893
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4670.191
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2230.927
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7790.807
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0890.803
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1060.938
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.4170.761
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1630.897
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3050.865
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0260.726
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolUCKL1
Nameuridine-cytidine kinase 1-like 1
Aliases FLJ20517; URKL1; uridine kinase-like 1; UCK1L; UCK1-LIKE; Uridine-cytidine kinase-like 1
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of UCKL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolUCKL1
Nameuridine-cytidine kinase 1-like 1
Aliases FLJ20517; URKL1; uridine kinase-like 1; UCK1L; UCK1-LIKE; Uridine-cytidine kinase-like 1
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of UCKL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by UCKL1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolUCKL1
Nameuridine-cytidine kinase 1-like 1
Aliases FLJ20517; URKL1; uridine kinase-like 1; UCK1L; UCK1-LIKE; Uridine-cytidine kinase-like 1
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of UCKL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolUCKL1
Nameuridine-cytidine kinase 1-like 1
Aliases FLJ20517; URKL1; uridine kinase-like 1; UCK1L; UCK1-LIKE; Uridine-cytidine kinase-like 1
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of UCKL1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolUCKL1
Nameuridine-cytidine kinase 1-like 1
Aliases FLJ20517; URKL1; uridine kinase-like 1; UCK1L; UCK1-LIKE; Uridine-cytidine kinase-like 1
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between UCKL1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolUCKL1
Nameuridine-cytidine kinase 1-like 1
Aliases FLJ20517; URKL1; uridine kinase-like 1; UCK1L; UCK1-LIKE; Uridine-cytidine kinase-like 1
Chromosomal Location20q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting UCKL1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting UCKL1.
ID Name Drug Type Targets #Targets
DB01632Alpha-Phosphoribosylpyrophosphoric AcidSmall MoleculeAPRT, HPRT1, UCKL13
DB03419UracilSmall MoleculeDPYD, UCKL12
DB03685Uridine monophosphateSmall MoleculeB4GALT1, GLT6D1, ISG20, LSM6, UCKL15
DB04137Guanosine-5'-TriphosphateSmall MoleculeADSSL1, ARF1, GLUD1, HRAS, PFKFB1, RAB5A, RAP2A, RHEB, RND3, UCKL110