Browse VAMP7

Summary
SymbolVAMP7
Namevesicle-associated membrane protein 7
Aliases VAMP-7; TI-VAMP; SYBL1; synaptobrevin-like 1; TIVAMP; synaptobrevin-like protein 1; tetanus neurotoxin-insen ......
Chromosomal LocationXq28 and Yq12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasmic vesicle, secretory vesicle membrane Single-pass type IV membrane protein Golgi apparatus, trans-Golgi network membrane Single-pass type IV membrane protein Late endosome membrane Single-pass type IV membrane protein Lysosome membrane Single-pass type IV membrane protein Endoplasmic reticulum membrane Single-pass type IV membrane protein Cytoplasmic vesicle, phagosome membrane Single-pass type IV membrane protein Cell junction, synapse, synaptosome Note=In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity).
Domain PF13774 Regulated-SNARE-like domain
PF00957 Synaptobrevin
Function

Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation.

> Gene Ontology
 
Biological Process GO:0001821 histamine secretion
GO:0001906 cell killing
GO:0001909 leukocyte mediated cytotoxicity
GO:0002228 natural killer cell mediated immunity
GO:0002263 cell activation involved in immune response
GO:0002274 myeloid leukocyte activation
GO:0002275 myeloid cell activation involved in immune response
GO:0002278 eosinophil activation involved in immune response
GO:0002279 mast cell activation involved in immune response
GO:0002283 neutrophil activation involved in immune response
GO:0002285 lymphocyte activation involved in immune response
GO:0002323 natural killer cell activation involved in immune response
GO:0002349 histamine production involved in inflammatory response
GO:0002366 leukocyte activation involved in immune response
GO:0002441 histamine secretion involved in inflammatory response
GO:0002443 leukocyte mediated immunity
GO:0002444 myeloid leukocyte mediated immunity
GO:0002446 neutrophil mediated immunity
GO:0002447 eosinophil mediated immunity
GO:0002448 mast cell mediated immunity
GO:0002449 lymphocyte mediated immunity
GO:0002532 production of molecular mediator involved in inflammatory response
GO:0002553 histamine secretion by mast cell
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002697 regulation of immune effector process
GO:0002699 positive regulation of immune effector process
GO:0002703 regulation of leukocyte mediated immunity
GO:0002705 positive regulation of leukocyte mediated immunity
GO:0002886 regulation of myeloid leukocyte mediated immunity
GO:0002888 positive regulation of myeloid leukocyte mediated immunity
GO:0006612 protein targeting to membrane
GO:0006623 protein targeting to vacuole
GO:0006869 lipid transport
GO:0006887 exocytosis
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006906 vesicle fusion
GO:0006909 phagocytosis
GO:0006911 phagocytosis, engulfment
GO:0007009 plasma membrane organization
GO:0007018 microtubule-based movement
GO:0007034 vacuolar transport
GO:0007041 lysosomal transport
GO:0008333 endosome to lysosome transport
GO:0009914 hormone transport
GO:0010324 membrane invagination
GO:0010720 positive regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010770 positive regulation of cell morphogenesis involved in differentiation
GO:0010817 regulation of hormone levels
GO:0010876 lipid localization
GO:0010970 transport along microtubule
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0016050 vesicle organization
GO:0016197 endosomal transport
GO:0016358 dendrite development
GO:0017156 calcium ion regulated exocytosis
GO:0017157 regulation of exocytosis
GO:0022604 regulation of cell morphogenesis
GO:0023061 signal release
GO:0030101 natural killer cell activation
GO:0030705 cytoskeleton-dependent intracellular transport
GO:0031346 positive regulation of cell projection organization
GO:0031349 positive regulation of defense response
GO:0032103 positive regulation of response to external stimulus
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032418 lysosome localization
GO:0033003 regulation of mast cell activation
GO:0033005 positive regulation of mast cell activation
GO:0033006 regulation of mast cell activation involved in immune response
GO:0033008 positive regulation of mast cell activation involved in immune response
GO:0033157 regulation of intracellular protein transport
GO:0034196 acylglycerol transport
GO:0034197 triglyceride transport
GO:0035493 SNARE complex assembly
GO:0036230 granulocyte activation
GO:0042119 neutrophil activation
GO:0042267 natural killer cell mediated cytotoxicity
GO:0043001 Golgi to plasma membrane protein transport
GO:0043299 leukocyte degranulation
GO:0043300 regulation of leukocyte degranulation
GO:0043302 positive regulation of leukocyte degranulation
GO:0043303 mast cell degranulation
GO:0043304 regulation of mast cell degranulation
GO:0043306 positive regulation of mast cell degranulation
GO:0043307 eosinophil activation
GO:0043308 eosinophil degranulation
GO:0043312 neutrophil degranulation
GO:0043320 natural killer cell degranulation
GO:0044395 protein targeting to vacuolar membrane
GO:0044801 single-organism membrane fusion
GO:0045055 regulated exocytosis
GO:0045117 azole transport
GO:0045576 mast cell activation
GO:0045666 positive regulation of neuron differentiation
GO:0045921 positive regulation of exocytosis
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046887 positive regulation of hormone secretion
GO:0047496 vesicle transport along microtubule
GO:0048193 Golgi vesicle transport
GO:0048280 vesicle fusion with Golgi apparatus
GO:0048284 organelle fusion
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048813 dendrite morphogenesis
GO:0048814 regulation of dendrite morphogenesis
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050769 positive regulation of neurogenesis
GO:0050773 regulation of dendrite development
GO:0050775 positive regulation of dendrite morphogenesis
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0051047 positive regulation of secretion
GO:0051608 histamine transport
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0051962 positive regulation of nervous system development
GO:0060627 regulation of vesicle-mediated transport
GO:0061025 membrane fusion
GO:0072384 organelle transport along microtubule
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0072665 protein localization to vacuole
GO:0072666 establishment of protein localization to vacuole
GO:0090002 establishment of protein localization to plasma membrane
GO:0090150 establishment of protein localization to membrane
GO:0090174 organelle membrane fusion
GO:0090313 regulation of protein targeting to membrane
GO:0099024 plasma membrane invagination
GO:0099518 vesicle cytoskeletal trafficking
GO:1900006 positive regulation of dendrite development
GO:1900483 regulation of protein targeting to vacuolar membrane
GO:1903305 regulation of regulated secretory pathway
GO:1903307 positive regulation of regulated secretory pathway
GO:1903335 regulation of vacuolar transport
GO:1903532 positive regulation of secretion by cell
GO:1903533 regulation of protein targeting
GO:1903593 regulation of histamine secretion by mast cell
GO:1903595 positive regulation of histamine secretion by mast cell
GO:1903778 protein localization to vacuolar membrane
GO:1990778 protein localization to cell periphery
Molecular Function GO:0000149 SNARE binding
GO:0005484 SNAP receptor activity
GO:0019905 syntaxin binding
Cellular Component GO:0005765 lysosomal membrane
GO:0005766 primary lysosome
GO:0005770 late endosome
GO:0005802 trans-Golgi network
GO:0010008 endosome membrane
GO:0030027 lamellipodium
GO:0030133 transport vesicle
GO:0030139 endocytic vesicle
GO:0030141 secretory granule
GO:0030658 transport vesicle membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030667 secretory granule membrane
GO:0030670 phagocytic vesicle membrane
GO:0031091 platelet alpha granule
GO:0031143 pseudopodium
GO:0031201 SNARE complex
GO:0031252 cell leading edge
GO:0031902 late endosome membrane
GO:0031984 organelle subcompartment
GO:0035577 azurophil granule membrane
GO:0042582 azurophil granule
GO:0044440 endosomal part
GO:0045177 apical part of cell
GO:0045335 phagocytic vesicle
GO:0098791 Golgi subcompartment
GO:0098852 lytic vacuole membrane
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04130 SNARE interactions in vesicular transport
Reactome R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis
R-HSA-421837: Clathrin derived vesicle budding
R-HSA-8856828: Clathrin-mediated endocytosis
R-HSA-432722: Golgi Associated Vesicle Biogenesis
R-HSA-432720: Lysosome Vesicle Biogenesis
R-HSA-199991: Membrane Trafficking
R-HSA-5653656: Vesicle-mediated transport
R-HSA-199992: trans-Golgi Network Vesicle Budding
Summary
SymbolVAMP7
Namevesicle-associated membrane protein 7
Aliases VAMP-7; TI-VAMP; SYBL1; synaptobrevin-like 1; TIVAMP; synaptobrevin-like protein 1; tetanus neurotoxin-insen ......
Chromosomal LocationXq28 and Yq12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between VAMP7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolVAMP7
Namevesicle-associated membrane protein 7
Aliases VAMP-7; TI-VAMP; SYBL1; synaptobrevin-like 1; TIVAMP; synaptobrevin-like protein 1; tetanus neurotoxin-insen ......
Chromosomal LocationXq28 and Yq12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of VAMP7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen Total # shRNA with >= 4-fold: 3 Resistant to T-cell proliferation
Summary
SymbolVAMP7
Namevesicle-associated membrane protein 7
Aliases VAMP-7; TI-VAMP; SYBL1; synaptobrevin-like 1; TIVAMP; synaptobrevin-like protein 1; tetanus neurotoxin-insen ......
Chromosomal LocationXq28 and Yq12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of VAMP7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2770.473
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5520.713
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0670.97
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0690.871
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3080.879
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.150.949
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3520.81
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7290.745
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1650.0221
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of VAMP7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolVAMP7
Namevesicle-associated membrane protein 7
Aliases VAMP-7; TI-VAMP; SYBL1; synaptobrevin-like 1; TIVAMP; synaptobrevin-like protein 1; tetanus neurotoxin-insen ......
Chromosomal LocationXq28 and Yq12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VAMP7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolVAMP7
Namevesicle-associated membrane protein 7
Aliases VAMP-7; TI-VAMP; SYBL1; synaptobrevin-like 1; TIVAMP; synaptobrevin-like protein 1; tetanus neurotoxin-insen ......
Chromosomal LocationXq28 and Yq12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VAMP7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VAMP7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolVAMP7
Namevesicle-associated membrane protein 7
Aliases VAMP-7; TI-VAMP; SYBL1; synaptobrevin-like 1; TIVAMP; synaptobrevin-like protein 1; tetanus neurotoxin-insen ......
Chromosomal LocationXq28 and Yq12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VAMP7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolVAMP7
Namevesicle-associated membrane protein 7
Aliases VAMP-7; TI-VAMP; SYBL1; synaptobrevin-like 1; TIVAMP; synaptobrevin-like protein 1; tetanus neurotoxin-insen ......
Chromosomal LocationXq28 and Yq12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of VAMP7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolVAMP7
Namevesicle-associated membrane protein 7
Aliases VAMP-7; TI-VAMP; SYBL1; synaptobrevin-like 1; TIVAMP; synaptobrevin-like protein 1; tetanus neurotoxin-insen ......
Chromosomal LocationXq28 and Yq12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between VAMP7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolVAMP7
Namevesicle-associated membrane protein 7
Aliases VAMP-7; TI-VAMP; SYBL1; synaptobrevin-like 1; TIVAMP; synaptobrevin-like protein 1; tetanus neurotoxin-insen ......
Chromosomal LocationXq28 and Yq12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting VAMP7 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.