Browse VPS11

Summary
SymbolVPS11
Namevacuolar protein sorting 11 homolog (S. cerevisiae)
Aliases RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ......
Chromosomal Location11q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endosome Late endosome membrane Peripheral membrane protein Cytoplasmic side Lysosome membrane Peripheral membrane protein Cytoplasmic side Early endosome Cytoplasmic vesicle Cytoplasmic vesicle, autophagosome Cytoplasmic vesicle, clathrin-coated vesicle
Domain PF00637 Region in Clathrin and VPS
PF12451 Vacuolar protein sorting protein 11 C terminal
Function

Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).

> Gene Ontology
 
Biological Process GO:0006626 protein targeting to mitochondrion
GO:0006839 mitochondrial transport
GO:0006887 exocytosis
GO:0006904 vesicle docking involved in exocytosis
GO:0006906 vesicle fusion
GO:0006914 autophagy
GO:0007032 endosome organization
GO:0007033 vacuole organization
GO:0007034 vacuolar transport
GO:0007040 lysosome organization
GO:0007041 lysosomal transport
GO:0008333 endosome to lysosome transport
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0016050 vesicle organization
GO:0016197 endosomal transport
GO:0016482 cytosolic transport
GO:0022406 membrane docking
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031338 regulation of vesicle fusion
GO:0031647 regulation of protein stability
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0033157 regulation of intracellular protein transport
GO:0034058 endosomal vesicle fusion
GO:0035493 SNARE complex assembly
GO:0035542 regulation of SNARE complex assembly
GO:0042176 regulation of protein catabolic process
GO:0043254 regulation of protein complex assembly
GO:0044801 single-organism membrane fusion
GO:0045022 early endosome to late endosome transport
GO:0045732 positive regulation of protein catabolic process
GO:0048278 vesicle docking
GO:0048284 organelle fusion
GO:0051222 positive regulation of protein transport
GO:0060627 regulation of vesicle-mediated transport
GO:0061025 membrane fusion
GO:0070585 protein localization to mitochondrion
GO:0072655 establishment of protein localization to mitochondrion
GO:0080171 lytic vacuole organization
GO:0090174 organelle membrane fusion
GO:0090316 positive regulation of intracellular protein transport
GO:0098927 vesicle-mediated transport between endosomal compartments
GO:1902115 regulation of organelle assembly
GO:1903214 regulation of protein targeting to mitochondrion
GO:1903335 regulation of vacuolar transport
GO:1903337 positive regulation of vacuolar transport
GO:1903362 regulation of cellular protein catabolic process
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903533 regulation of protein targeting
GO:1903649 regulation of cytoplasmic transport
GO:1903651 positive regulation of cytoplasmic transport
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1904951 positive regulation of establishment of protein localization
GO:2000641 regulation of early endosome to late endosome transport
GO:2000643 positive regulation of early endosome to late endosome transport
Molecular Function GO:0000149 SNARE binding
GO:0019905 syntaxin binding
GO:0030674 protein binding, bridging
GO:0060090 binding, bridging
Cellular Component GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005776 autophagosome
GO:0010008 endosome membrane
GO:0030135 coated vesicle
GO:0030136 clathrin-coated vesicle
GO:0030139 endocytic vesicle
GO:0030897 HOPS complex
GO:0031902 late endosome membrane
GO:0044440 endosomal part
GO:0098852 lytic vacuole membrane
GO:0099023 tethring complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolVPS11
Namevacuolar protein sorting 11 homolog (S. cerevisiae)
Aliases RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ......
Chromosomal Location11q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between VPS11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolVPS11
Namevacuolar protein sorting 11 homolog (S. cerevisiae)
Aliases RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ......
Chromosomal Location11q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of VPS11 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.49; FDR: 0.04110 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolVPS11
Namevacuolar protein sorting 11 homolog (S. cerevisiae)
Aliases RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ......
Chromosomal Location11q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of VPS11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1350.45
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0680.971
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2890.818
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0410.859
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1710.933
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.310.906
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0690.829
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0790.96
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2910.872
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0240.988
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0420.986
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0340.529
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of VPS11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolVPS11
Namevacuolar protein sorting 11 homolog (S. cerevisiae)
Aliases RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ......
Chromosomal Location11q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VPS11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolVPS11
Namevacuolar protein sorting 11 homolog (S. cerevisiae)
Aliases RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ......
Chromosomal Location11q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VPS11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VPS11.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolVPS11
Namevacuolar protein sorting 11 homolog (S. cerevisiae)
Aliases RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ......
Chromosomal Location11q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VPS11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolVPS11
Namevacuolar protein sorting 11 homolog (S. cerevisiae)
Aliases RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ......
Chromosomal Location11q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of VPS11 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolVPS11
Namevacuolar protein sorting 11 homolog (S. cerevisiae)
Aliases RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ......
Chromosomal Location11q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between VPS11 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolVPS11
Namevacuolar protein sorting 11 homolog (S. cerevisiae)
Aliases RNF108; PEP5; vacuolar protein sorting 11 (yeast homolog); END1; hVPS11; RING finger protein 108; Vacuolar p ......
Chromosomal Location11q23.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting VPS11 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.