TISIDB

Summary
Symbol	VPS37D
Name	vacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases	MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location	7q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Late endosome membrane Peripheral membrane protein
Domain	PF07200 Modifier of rudimentary (Mod(r)) protein
Function	Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.

> Gene Ontology [ TOP ]
Biological Process	GO:0006900 membrane budding GO:0006914 autophagy GO:0007032 endosome organization GO:0007033 vacuole organization GO:0007034 vacuolar transport GO:0016050 vesicle organization GO:0016197 endosomal transport GO:0019058 viral life cycle GO:0019068 virion assembly GO:0036257 multivesicular body organization GO:0036258 multivesicular body assembly GO:0039702 viral budding via host ESCRT complex GO:0044766 multi-organism transport GO:0044803 multi-organism membrane organization GO:0046755 viral budding GO:0046794 transport of virus GO:0075733 intracellular transport of virus GO:1902579 multi-organism localization GO:1902581 multi-organism cellular localization GO:1902583 multi-organism intracellular transport GO:1902590 multi-organism organelle organization GO:1902592 multi-organism membrane budding
Molecular Function	-
Cellular Component	GO:0000813 ESCRT I complex GO:0005770 late endosome GO:0010008 endosome membrane GO:0031902 late endosome membrane GO:0036452 ESCRT complex GO:0044440 endosomal part

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04144 Endocytosis
Reactome	R-HSA-175474: Assembly Of The HIV Virion R-HSA-162588: Budding and maturation of HIV virion R-HSA-1643685: Disease R-HSA-917729: Endosomal Sorting Complex Required For Transport (ESCRT) R-HSA-162906: HIV Infection R-HSA-162587: HIV Life Cycle R-HSA-5663205: Infectious disease R-HSA-162599: Late Phase of HIV Life Cycle R-HSA-199991: Membrane Trafficking R-HSA-174490: Membrane binding and targetting of GAG proteins R-HSA-174495: Synthesis And Processing Of GAG, GAGPOL Polyproteins R-HSA-5653656: Vesicle-mediated transport

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04144 Endocytosis

Reactome

R-HSA-175474: Assembly Of The HIV Virion
R-HSA-162588: Budding and maturation of HIV virion
R-HSA-1643685: Disease
R-HSA-917729: Endosomal Sorting Complex Required For Transport (ESCRT)
R-HSA-162906: HIV Infection
R-HSA-162587: HIV Life Cycle
R-HSA-5663205: Infectious disease
R-HSA-162599: Late Phase of HIV Life Cycle
R-HSA-199991: Membrane Trafficking
R-HSA-174490: Membrane binding and targetting of GAG proteins
R-HSA-174495: Synthesis And Processing Of GAG, GAGPOL Polyproteins
R-HSA-5653656: Vesicle-mediated transport

Summary
Symbol	VPS37D
Name	vacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases	MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location	7q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between VPS37D and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	VPS37D
Name	vacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases	MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location	7q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of VPS37D in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	Second most enriched score: 0.65	Sensitive to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	VPS37D
Name	vacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases	MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location	7q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of VPS37D in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.055	0.901
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.249	0.804
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.279	0.736
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.261	0.701
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.552	0.61
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.095	0.944
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.265	0.53
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.446	0.488
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.028	0.968
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.284	0.77
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.217	0.871
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.059	0.774

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of VPS37D in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	11.8	-11.8	0.488
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	14.3	-14.3	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	VPS37D
Name	vacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases	MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location	7q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of VPS37D. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	VPS37D
Name	vacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases	MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location	7q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of VPS37D. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by VPS37D. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	VPS37D
Name	vacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases	MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location	7q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of VPS37D. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	VPS37D
Name	vacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases	MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location	7q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of VPS37D expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	VPS37D
Name	vacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases	MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location	7q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between VPS37D and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	VPS37D
Name	vacuolar protein sorting 37 homolog D (S. cerevisiae)
Aliases	MGC35352; WBSCR24; Williams Beuren syndrome chromosome region 24; vacuolar protein sorting 37D (yeast); ESCR ......
Chromosomal Location	7q11.23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting VPS37D collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse VPS37D