Browse WDR35

Summary
SymbolWDR35
NameWD repeat domain 35
Aliases MGC33196; KIAA1336; IFT121; IFTA1; CED2; SRTD7; intraflagellar transport protein 121 homolog; naofen; WD rep ......
Chromosomal Location2p24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, cilium axoneme Cytoplasm, cytoskeleton, cilium basal body
Domain PF12894 Anaphase-promoting complex subunit 4 WD40 domain
Function

Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Required for ciliogenesis. May promote CASP3 activation and TNF-stimulated apoptosis.

> Gene Ontology
 
Biological Process GO:0007018 microtubule-based movement
GO:0010927 cellular component assembly involved in morphogenesis
GO:0010970 transport along microtubule
GO:0030031 cell projection assembly
GO:0030705 cytoskeleton-dependent intracellular transport
GO:0031503 protein complex localization
GO:0035721 intraciliary retrograde transport
GO:0042073 intraciliary transport
GO:0042384 cilium assembly
GO:0044782 cilium organization
GO:0060271 cilium morphogenesis
GO:0061512 protein localization to cilium
GO:0098840 protein transport along microtubule
Molecular Function GO:0005543 phospholipid binding
GO:0035091 phosphatidylinositol binding
Cellular Component GO:0005813 centrosome
GO:0005929 cilium
GO:0005930 axoneme
GO:0030990 intraciliary transport particle
GO:0030991 intraciliary transport particle A
GO:0036064 ciliary basal body
GO:0044441 ciliary part
GO:0072372 primary cilium
GO:0097014 ciliary plasm
GO:0097542 ciliary tip
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-5617833: Cilium Assembly
R-HSA-5610787: Hedgehog 'off' state
R-HSA-5620924: Intraflagellar transport
R-HSA-1852241: Organelle biogenesis and maintenance
R-HSA-162582: Signal Transduction
R-HSA-5358351: Signaling by Hedgehog
Summary
SymbolWDR35
NameWD repeat domain 35
Aliases MGC33196; KIAA1336; IFT121; IFTA1; CED2; SRTD7; intraflagellar transport protein 121 homolog; naofen; WD rep ......
Chromosomal Location2p24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between WDR35 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolWDR35
NameWD repeat domain 35
Aliases MGC33196; KIAA1336; IFT121; IFTA1; CED2; SRTD7; intraflagellar transport protein 121 homolog; naofen; WD rep ......
Chromosomal Location2p24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of WDR35 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolWDR35
NameWD repeat domain 35
Aliases MGC33196; KIAA1336; IFT121; IFTA1; CED2; SRTD7; intraflagellar transport protein 121 homolog; naofen; WD rep ......
Chromosomal Location2p24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of WDR35 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0430.899
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1620.892
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0460.958
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5010.113
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.610.736
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3670.867
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1890.609
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3550.816
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0750.962
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1740.846
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5230.674
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0110.885
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of WDR35 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.1011.10.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.1011.10.0286
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.26.2160.53
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.67.4-4.80.565
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.57.7-3.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 6116.7016.71
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolWDR35
NameWD repeat domain 35
Aliases MGC33196; KIAA1336; IFT121; IFTA1; CED2; SRTD7; intraflagellar transport protein 121 homolog; naofen; WD rep ......
Chromosomal Location2p24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of WDR35. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolWDR35
NameWD repeat domain 35
Aliases MGC33196; KIAA1336; IFT121; IFTA1; CED2; SRTD7; intraflagellar transport protein 121 homolog; naofen; WD rep ......
Chromosomal Location2p24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of WDR35. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by WDR35.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolWDR35
NameWD repeat domain 35
Aliases MGC33196; KIAA1336; IFT121; IFTA1; CED2; SRTD7; intraflagellar transport protein 121 homolog; naofen; WD rep ......
Chromosomal Location2p24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of WDR35. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolWDR35
NameWD repeat domain 35
Aliases MGC33196; KIAA1336; IFT121; IFTA1; CED2; SRTD7; intraflagellar transport protein 121 homolog; naofen; WD rep ......
Chromosomal Location2p24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of WDR35 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolWDR35
NameWD repeat domain 35
Aliases MGC33196; KIAA1336; IFT121; IFTA1; CED2; SRTD7; intraflagellar transport protein 121 homolog; naofen; WD rep ......
Chromosomal Location2p24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between WDR35 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolWDR35
NameWD repeat domain 35
Aliases MGC33196; KIAA1336; IFT121; IFTA1; CED2; SRTD7; intraflagellar transport protein 121 homolog; naofen; WD rep ......
Chromosomal Location2p24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting WDR35 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.