Browse WNT7A

Summary
SymbolWNT7A
Namewingless-type MMTV integration site family, member 7A
Aliases proto-oncogene Wnt7a protein; Protein Wnt-7a
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted, extracellular space, extracellular matrix Secreted
Domain PF00110 wnt family
Function

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development (PubMed:16826533). Required for normal, sexually dimorphic development of the Mullerian ducts, and for normal fertility in both sexes. Required for normal neural stem cell proliferation in the hippocampus dentate gyrus. Required for normal progress through the cell cycle in neural progenitor cells, for self-renewal of neural stem cells, and for normal neuronal differentiation and maturation. Promotes formation of synapses via its interaction with FZD5 (By similarity).

> Gene Ontology
 
Biological Process GO:0000578 embryonic axis specification
GO:0001501 skeletal system development
GO:0001502 cartilage condensation
GO:0001505 regulation of neurotransmitter levels
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001654 eye development
GO:0001667 ameboidal-type cell migration
GO:0001885 endothelial cell development
GO:0002011 morphogenesis of an epithelial sheet
GO:0002062 chondrocyte differentiation
GO:0002064 epithelial cell development
GO:0002088 lens development in camera-type eye
GO:0003002 regionalization
GO:0003158 endothelium development
GO:0006836 neurotransmitter transport
GO:0007163 establishment or maintenance of cell polarity
GO:0007254 JNK cascade
GO:0007269 neurotransmitter secretion
GO:0007389 pattern specification process
GO:0007409 axonogenesis
GO:0007416 synapse assembly
GO:0007423 sensory organ development
GO:0007548 sex differentiation
GO:0008105 asymmetric protein localization
GO:0009798 axis specification
GO:0009880 embryonic pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0010594 regulation of endothelial cell migration
GO:0010595 positive regulation of endothelial cell migration
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010721 negative regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010975 regulation of neuron projection development
GO:0014045 establishment of endothelial blood-brain barrier
GO:0014719 skeletal muscle satellite cell activation
GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO:0016055 Wnt signaling pathway
GO:0016358 dendrite development
GO:0017145 stem cell division
GO:0019827 stem cell population maintenance
GO:0021533 cell differentiation in hindbrain
GO:0021549 cerebellum development
GO:0021575 hindbrain morphogenesis
GO:0021587 cerebellum morphogenesis
GO:0021681 cerebellar granular layer development
GO:0021683 cerebellar granular layer morphogenesis
GO:0021684 cerebellar granular layer formation
GO:0021695 cerebellar cortex development
GO:0021696 cerebellar cortex morphogenesis
GO:0021697 cerebellar cortex formation
GO:0021707 cerebellar granule cell differentiation
GO:0021846 cell proliferation in forebrain
GO:0021953 central nervous system neuron differentiation
GO:0022009 central nervous system vasculogenesis
GO:0022037 metencephalon development
GO:0022604 regulation of cell morphogenesis
GO:0023061 signal release
GO:0030010 establishment of cell polarity
GO:0030111 regulation of Wnt signaling pathway
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030326 embryonic limb morphogenesis
GO:0030335 positive regulation of cell migration
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031099 regeneration
GO:0031133 regulation of axon diameter
GO:0032355 response to estradiol
GO:0032535 regulation of cellular component size
GO:0032536 regulation of cell projection size
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0035019 somatic stem cell population maintenance
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035116 embryonic hindlimb morphogenesis
GO:0035136 forelimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0035313 wound healing, spreading of epidermal cells
GO:0035418 protein localization to synapse
GO:0035567 non-canonical Wnt signaling pathway
GO:0035659 Wnt signaling pathway involved in wound healing, spreading of epidermal cells
GO:0036465 synaptic vesicle recycling
GO:0040017 positive regulation of locomotion
GO:0042246 tissue regeneration
GO:0042391 regulation of membrane potential
GO:0042733 embryonic digit morphogenesis
GO:0043010 camera-type eye development
GO:0043403 skeletal muscle tissue regeneration
GO:0043410 positive regulation of MAPK cascade
GO:0043542 endothelial cell migration
GO:0043627 response to estrogen
GO:0044089 positive regulation of cellular component biogenesis
GO:0044319 wound healing, spreading of cells
GO:0045165 cell fate commitment
GO:0045446 endothelial cell differentiation
GO:0046328 regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0048103 somatic stem cell division
GO:0048489 synaptic vesicle transport
GO:0048514 blood vessel morphogenesis
GO:0048608 reproductive structure development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048705 skeletal system morphogenesis
GO:0048736 appendage development
GO:0048813 dendrite morphogenesis
GO:0048863 stem cell differentiation
GO:0048864 stem cell development
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050768 negative regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0050803 regulation of synapse structure or activity
GO:0050804 modulation of synaptic transmission
GO:0050806 positive regulation of synaptic transmission
GO:0050807 regulation of synapse organization
GO:0050808 synapse organization
GO:0051216 cartilage development
GO:0051272 positive regulation of cellular component movement
GO:0051403 stress-activated MAPK cascade
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0051961 negative regulation of nervous system development
GO:0051962 positive regulation of nervous system development
GO:0051963 regulation of synapse assembly
GO:0051965 positive regulation of synapse assembly
GO:0060021 palate development
GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing
GO:0060065 uterus development
GO:0060066 oviduct development
GO:0060070 canonical Wnt signaling pathway
GO:0060078 regulation of postsynaptic membrane potential
GO:0060079 excitatory postsynaptic potential
GO:0060173 limb development
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0060856 establishment of blood-brain barrier
GO:0060996 dendritic spine development
GO:0060997 dendritic spine morphogenesis
GO:0061028 establishment of endothelial barrier
GO:0061038 uterus morphogenesis
GO:0061351 neural precursor cell proliferation
GO:0061448 connective tissue development
GO:0061458 reproductive system development
GO:0061564 axon development
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070306 lens fiber cell differentiation
GO:0070307 lens fiber cell development
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090066 regulation of anatomical structure size
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0090504 epiboly
GO:0090505 epiboly involved in wound healing
GO:0097061 dendritic spine organization
GO:0097479 synaptic vesicle localization
GO:0097480 establishment of synaptic vesicle localization
GO:0098727 maintenance of cell number
GO:0098743 cell aggregation
GO:0098815 modulation of excitatory postsynaptic potential
GO:0099003 vesicle-mediated transport in synapse
GO:0099054 presynapse assembly
GO:0099068 postsynapse assembly
GO:0099504 synaptic vesicle cycle
GO:0099531 presynaptic process involved in chemical synaptic transmission
GO:0099565 chemical synaptic transmission, postsynaptic
GO:0099643 signal release from synapse
GO:0198738 cell-cell signaling by wnt
GO:1902473 regulation of protein localization to synapse
GO:1902474 positive regulation of protein localization to synapse
GO:1904861 excitatory synapse assembly
GO:1904889 regulation of excitatory synapse assembly
GO:1904891 positive regulation of excitatory synapse assembly
GO:1905383 protein localization to presynapse
GO:1905384 regulation of protein localization to presynapse
GO:1905386 positive regulation of protein localization to presynapse
GO:2000147 positive regulation of cell motility
GO:2000463 positive regulation of excitatory postsynaptic potential
Molecular Function GO:0001664 G-protein coupled receptor binding
GO:0005109 frizzled binding
GO:0005125 cytokine activity
GO:0030545 receptor regulator activity
GO:0030546 receptor activator activity
GO:0048018 receptor agonist activity
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0030139 endocytic vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0098793 presynapse
> KEGG and Reactome Pathway
 
KEGG hsa04150 mTOR signaling pathway
hsa04310 Wnt signaling pathway
hsa04390 Hippo signaling pathway
hsa04550 Signaling pathways regulating pluripotency of stem cells
hsa04916 Melanogenesis
Reactome R-HSA-373080: Class B/2 (Secretin family receptors)
R-HSA-500792: GPCR ligand binding
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-195721: Signaling by Wnt
R-HSA-3238698: WNT ligand biogenesis and trafficking
Summary
SymbolWNT7A
Namewingless-type MMTV integration site family, member 7A
Aliases proto-oncogene Wnt7a protein; Protein Wnt-7a
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between WNT7A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolWNT7A
Namewingless-type MMTV integration site family, member 7A
Aliases proto-oncogene Wnt7a protein; Protein Wnt-7a
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of WNT7A in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolWNT7A
Namewingless-type MMTV integration site family, member 7A
Aliases proto-oncogene Wnt7a protein; Protein Wnt-7a
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of WNT7A in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.290.35
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0030.996
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.5040.356
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.9830.106
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6630.535
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.3860.265
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.8690.0208
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of WNT7A in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolWNT7A
Namewingless-type MMTV integration site family, member 7A
Aliases proto-oncogene Wnt7a protein; Protein Wnt-7a
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of WNT7A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolWNT7A
Namewingless-type MMTV integration site family, member 7A
Aliases proto-oncogene Wnt7a protein; Protein Wnt-7a
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of WNT7A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by WNT7A.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolWNT7A
Namewingless-type MMTV integration site family, member 7A
Aliases proto-oncogene Wnt7a protein; Protein Wnt-7a
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of WNT7A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolWNT7A
Namewingless-type MMTV integration site family, member 7A
Aliases proto-oncogene Wnt7a protein; Protein Wnt-7a
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of WNT7A expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolWNT7A
Namewingless-type MMTV integration site family, member 7A
Aliases proto-oncogene Wnt7a protein; Protein Wnt-7a
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between WNT7A and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolWNT7A
Namewingless-type MMTV integration site family, member 7A
Aliases proto-oncogene Wnt7a protein; Protein Wnt-7a
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting WNT7A collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.