TISIDB

Summary
Symbol	XRCC1
Name	X-ray repair complementing defective repair in Chinese hamster cells 1
Aliases	RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage.
Domain	PF00533 BRCA1 C Terminus (BRCT) domain PF16589 BRCT domain PF01834 XRCC1 N terminal domain
Function	Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity.

> Gene Ontology [ TOP ]
Biological Process	GO:0000012 single strand break repair GO:0000724 double-strand break repair via homologous recombination GO:0000725 recombinational repair GO:0001666 response to hypoxia GO:0006266 DNA ligation GO:0006283 transcription-coupled nucleotide-excision repair GO:0006284 base-excision repair GO:0006288 base-excision repair, DNA ligation GO:0006289 nucleotide-excision repair GO:0006297 nucleotide-excision repair, DNA gap filling GO:0006302 double-strand break repair GO:0006310 DNA recombination GO:0021537 telencephalon development GO:0021543 pallium development GO:0021761 limbic system development GO:0021766 hippocampus development GO:0030900 forebrain development GO:0036293 response to decreased oxygen levels GO:0042493 response to drug GO:0051103 DNA ligation involved in DNA repair GO:0070482 response to oxygen levels
Molecular Function	GO:0003684 damaged DNA binding GO:0003909 DNA ligase activity GO:0016874 ligase activity GO:0016886 ligase activity, forming phosphoric ester bonds
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03410 Base excision repair
Reactome	R-HSA-5649702: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-73884: Base Excision Repair R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-5696397: Gap-filling DNA repair synthesis and ligation in GG-NER R-HSA-6782210: Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER) R-HSA-5685939: HDR through MMEJ (alt-NHEJ) R-HSA-5693538: Homology Directed Repair R-HSA-5696398: Nucleotide Excision Repair R-HSA-110381: Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-73933: Resolution of Abasic Sites (AP sites) R-HSA-6781827: Transcription-Coupled Nucleotide Excision Repair (TC-NER)

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa03410 Base excision repair

Reactome

R-HSA-5649702: APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-73884: Base Excision Repair
R-HSA-5693532: DNA Double-Strand Break Repair
R-HSA-73894: DNA Repair
R-HSA-5696397: Gap-filling DNA repair synthesis and ligation in GG-NER
R-HSA-6782210: Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-5685939: HDR through MMEJ (alt-NHEJ)
R-HSA-5693538: Homology Directed Repair
R-HSA-5696398: Nucleotide Excision Repair
R-HSA-110381: Resolution of AP sites via the single-nucleotide replacement pathway
R-HSA-73933: Resolution of Abasic Sites (AP sites)
R-HSA-6781827: Transcription-Coupled Nucleotide Excision Repair (TC-NER)

Summary
Symbol	XRCC1
Name	X-ray repair complementing defective repair in Chinese hamster cells 1
Aliases	RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between XRCC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	XRCC1
Name	X-ray repair complementing defective repair in Chinese hamster cells 1
Aliases	RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of XRCC1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	logFC: -2.54; FDR: 0.04180	Resistant to T cell-mediated killing
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	XRCC1
Name	X-ray repair complementing defective repair in Chinese hamster cells 1
Aliases	RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of XRCC1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.145	0.514
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.334	0.869
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.008	0.996
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.379	0.137
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.684	0.741
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.008	0.998
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.096	0.748
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.038	0.977
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.206	0.891
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.031	0.982
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.233	0.908
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.154	0.0116

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of XRCC1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	6.8	-3.1	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	14.3	-14.3	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	5.1	-1.4	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	9.5	0	9.5	0.492
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	0	12.5	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	0	20	0.357
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	XRCC1
Name	X-ray repair complementing defective repair in Chinese hamster cells 1
Aliases	RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of XRCC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	XRCC1
Name	X-ray repair complementing defective repair in Chinese hamster cells 1
Aliases	RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of XRCC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by XRCC1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	XRCC1
Name	X-ray repair complementing defective repair in Chinese hamster cells 1
Aliases	RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of XRCC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	XRCC1
Name	X-ray repair complementing defective repair in Chinese hamster cells 1
Aliases	RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of XRCC1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	XRCC1
Name	X-ray repair complementing defective repair in Chinese hamster cells 1
Aliases	RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between XRCC1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	XRCC1
Name	X-ray repair complementing defective repair in Chinese hamster cells 1
Aliases	RCC; X-ray repair cross-complementing protein 1; DNA repair protein XRCC1
Chromosomal Location	19q13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting XRCC1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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